@article{ajcmr2013131,
author={AUTHOR = {Lin, Yu-Wei and Lin, Thy-Sheng and Lai, Ming-Liang},
title={The Correlation between Uric Acid Levels and Amyotrophic Lateral Sclerosis},
journal={American Journal of Clinical Medicine Research},
volume={1},
number={3},
pages={35--39},
year={2013},
url={http://pubs.sciepub.com/ajcmr/1/3/1},
issn={2328-403X},
abstract={<b>Introduction</b> Uric acid (UA) may act as an antioxidant in ALS pathophysiology. This study examined whether serum UA concentration correlates to clinical course in the ALS patients. <b>Methods</b><b> </b>We measured serum UA levels in 51 sporadic ALS patients, and compared them to 51 age-and-gender-matched healthy subjects. We analyzed the correlation between serum UA levels, illness duration, and disease ˇ°course factorsˇ± (defined as ˇ°disease durationˇ± over ˇ°terminal timeˇ±) in the ALS patients. <b>Results</b><b> </b>The mean serum UA levels in the ALS groups were higher than the control groups in both genders. Serum UA levels were inversely correlated with the disease ˇ°course factorsˇ± in the ALS male patients. <b>Discussion</b><b> </b>The elevation of serum UA concentration in ALS patients may be related to oxidative stress. The reasons that serum UA levels inversely correlated with ALS ˇ°course factorsˇ± include: muscle wasting, poor nutrition, reduced antioxidant reserve, or increased UA consumption in end-stage patients.},
doi={10.12691/ajcmr-1-3-1}
publisher={Science and Education Publishing}
}