Science and Education Publishing American Journal of Cardiovascular Disease Research 4 2 2016 9 22 Amyloid Cardiomyopathy in African Americans and the Transthyretin Linkage Associated with Macroglossia: A Rare Presentation 21 24 EN Roberto Ramirez Glenmore Lasam Department of Medicine, Overlook Medical Center, Summit, NJ 07901 USA Gina LaCapra AJCDR2016423 10.12691/ajcdr-4-2-3 2016 5 6 2016 8 9 2016 9 20 We report a case of a 63 year old African American female with congestive heart failure, poorly controlled hypertension, and end stage renal disease admitted for STEMI (ST Elevation Myocardial Infarction) and hypertensive crisis. Macroglossia was noticed during hospitalization and an echocardiogram was suggestive of cardiac infiltrative disease. Protein electrophoresis and immunofixation were negative. Although macroglossia is a common finding in light chain (AL) amyloidosis, there are reported cases in transthyretin (ATTR) amyloidosis. Learning objective: To highlight a rare presentation of transthyretin amyloidosis, and to raise awareness of this disease and its particular prevalence in the African American and African Caribbean populations.