@article{ajbr2017521,
author={{O.V., Ikpeazu and I., Elekwa and A.E., Ugbogu and U.O., Arunsi and C., Uche-Ikonne},
title={Preliminary Evaluation of Anti-ulcer Potential of Aqueous Extract of Fermented Unripe <i>Musa paradisiaca </i>in Wistar Rats},
journal={American Journal of Biomedical Research},
volume={5},
number={2},
pages={17--23},
year={2017},
url={http://pubs.sciepub.com/ajbr/5/2/1},
issn={2328-3955},
abstract={<i>Musa paradisiaca</i> Linn. belonging to the family Musaceae is a common medicinal plants use in herbal medicine for the treatment of diseases like diabetics, hypertension and ulcer. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented unripe <i>M. paradisiaca </i>fruits using acetic acid, aspirin, ethanol, indomethacin and pyloric ligation-induced ulcer models at the doses of 400 and 800 mg/kg body weight. Omeprazole at 5 mg/kg was used as a standard reference drug. The result of the acute toxicity test showed that up to 5,000 mg/kg body weight of the extract did not cause any mortality of the wistar rats. The different doses of the extract and the reference drug significantly (p&lt;0.05) decreased all the ulcer parameters (ulcer score and ulcer index) in a dose dependent manner in all the ulcer models. The degree of ulcer index is in the order: Pyloric-ligation (11.33¡À0.12) &lt; Indomethacin (12.03¡À0.14) &lt; Acetic acid (12.17¡À0.23) &lt; Aspirin (13.20¡À0.10) &lt; Ethanol (15.60¡À0.40). Similarly, the percentage gastro-protective activity increased from 0% in the negative control up to 23.56% at the dose of 800mg/kg body weight of the extract. The degree of percentage gastro-protection is in the order: Pyloric-ligation (7.93%) &lt; Indomethacin (10.51%) &lt; Acetic acid (13.51%) &lt; Ethanol (22.19%) &lt; Aspirin (23.56%). The enhanced cessation of gastric erosions could be attributed to the synergistic role of probiotics and phytochemicals in the plant extract. In conclusion, fermented unripe <i>M. paradisiaca </i>fruit extract is a good candidate for screening of new antiulcer drugs.},
doi={10.12691/ajbr-5-2-1}
publisher={Science and Education Publishing}
}