@article{ajbr2017513,
author={S.A, Salami},
title={Effect of Gestational Oral <i>Ricinus communis</i> Oil Ingestion on Haematological Parameters in Wistar Rats},
journal={American Journal of Biomedical Research},
volume={5},
number={1},
pages={14--16},
year={2017},
url={http://pubs.sciepub.com/ajbr/5/1/3},
issn={2328-3955},
abstract={<b>Objective</b>: Haematological effect associated with <i>Ricinus communis </i>oil (RCO) ingestion at different gestation periods was investigated in wistar rats. <b>Methods</b>: 30 pregnant rats were randomly shared into 5 groups of six rats each. Group 1 (control) received distilled water while groups 2-5 received 950 mg/kg BW RCO orally between gestation days (GD) 1-7, 7-14, 14-21, and 1-21 respectively. Maternal haematological parameters were determined by conventional methods and data were analyzed using graph pad prism software. Statistical significance was taken at p&lt;0.05. <b>Results</b>: There were significant increases in packed cell volume (PCV), haemoglobin concentration (Hb) and red blood cell count (RBC) in GD 14-21 treated rats as compared to control. However mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) decreased significantly. GD 1-7 treated rats showed a reduction in PCVwhen compared to control. Percentage variations/changes in leucocyte cells values were all not statistically different from control values. <b>Conclusion</b>: Oral RCO exposure at different gestation periods has no significant effect on differential leucocytes cells count but appears to reduce and enhance erythropoiesis at early and late gestation period respectively.},
doi={10.12691/ajbr-5-1-3}
publisher={Science and Education Publishing}
}