@article{ajbr2016441,
author={{A.E., Ugbogu and E., Okezie and C., Uche-Ikonne and M., Duru and O.C., Atasie},
title={Toxicity Evaluation of the Aqueous Stem Extracts of <i>Senna alata</i> in Wistar Rats},
journal={American Journal of Biomedical Research},
volume={4},
number={4},
pages={80--86},
year={2016},
url={http://pubs.sciepub.com/ajbr/4/4/1},
issn={2328-3955},
abstract={Aim: This study evaluated the phytochemicals, proximate and the toxicity effect of aqueous stem extract of <i>Senna alata</i> using wistar rats. In acute toxicity test, aqueous dried stem extract of <i>Senna alata</i> were administered orally up to 10 g/kg body weight to male wistar rats. Materials and methods: In sub-acute study, the wistar rats were daily administered orally with aqueous dried stem extract of <i>Senna alata</i> at doses of 250, 500 and 1000 mg/kg for 14 days and haematological, biochemical parameters were determined and a histopathology of the liver and kidney were analyzed. Results: The acute toxicity of oral administration of aqueous extracts of <i>Senna alata</i> stem on albino rats after 24 hours did not produce any mortality at concentration up to 10 g/kg body weight. In the subacute toxicity, significant differences (P> 0.05) were observed in the results of urea, creatinine, and bicarbonate across the tested groups when compared with the control rats. The results of the liver enzymes showed significant difference (P> 0.05) on alkaline transaminase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP). Conclusion: Our results showed that the dried stem of <i>Senna alata</i> is not toxic at the tested doses.},
doi={10.12691/ajbr-4-4-1}
publisher={Science and Education Publishing}
}