@article{ajbr2016433,
author={{Ali, Kefah H and Sabek, Nagwan A and Eldeen, Loaa A Tag and Ismail, Emad F and Nasr, Gamela},
title={Methylenetetrahydrofolate Reductase C677T and Platelet Glycoprotein IIb/IIIa Genes Polymorphism in Myocardial Infarction Egyptian Patients in Ismailia City},
journal={American Journal of Biomedical Research},
volume={4},
number={3},
pages={74--79},
year={2016},
url={http://pubs.sciepub.com/ajbr/4/3/3},
issn={2328-3955},
abstract={<b>Background</b>: Hyperhomocysteinemia and platelet glycoprotein GpIIIa<SUB> </SUB>polymorphism had been identified as risk factors for coronary atherosclerosis. The methylenetetrahydrofolate reductase <i>MTHFR</i> C677T variant has been shown to influence homocysteine metabolism, the interaction of plasma tHcy with other conventional risk factors remain uncertain in the clinical setting of acute myocardial infarction (AMI). The present study aimed to examine whether the <i>MTHFR </i>and platelet glycoprotein<i> IIIa </i>polymorphisms were associated with increased risk of (MI) in Egyptian patients. <b>Subjects</b><b> and Method:</b><b> </b>150 newly diagnosed MI patients and 50 healthy matched subjects were recruited into this study, genotyping of the <i>MTHFR </i>C677T and <i>GpIIIa</i> 1565 A<SUP>1</SUP>/A<SUP>2</SUP> polymorphisms were carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, plasma tHcy, and folic acid levels were estimated.<b> Results</b>: Fasting plasma total Hcy levels were significantly higher in MI patients than controls (<i>P </i>&lt;0.05), folate levels were significantly lower in MI patients than controls (<i>P </i>&lt;0.05), no significant differences were observed in the <i>MTHFR</i> C677T and <i>GpIIIa</i> genotypes frequencies between MI patients and controls (<i>P </i>> 0.05). The frequency of the <i>MTHFR</i> C allele was 80.6 % and 76 % in MI patients and controls respectively and did not differ significantly between the two groups (P > 0.05). The frequency of risk allele, GpIIIa, PIA<SUP>2</SUP> was significantly higher in MI patients compared to controls (p&lt;0.05), plasma tHcy level was significantly higher and folate level was significantly lower in MI patients carrying <i>MTHFR</i> CC and <i>GPIIIa </i>PIA<SUP>2</SUP>A<SUP>2</SUP>genotypes. <b>Conclusions</b>: In this population, the both risk alleles of <i>MTHFR</i> and <i>GpIIb/IIIa</i> polymorphisms had no major effect on the MI incidence, they were associated with higher homocysteine levels. A gene-environment interaction might increase the risk indirectly by elevating tHcy, especially when folate intake was low, our findings might support that <i>MTHFR</i> and <i>GpIIb/IIIa </i>polymorphisms as risk factors for MI.},
doi={10.12691/ajbr-4-3-3}
publisher={Science and Education Publishing}
}