eng Science and Education Publishing American Journal of Biomedical Research 2328-3955 2016-05-13 4 2 42 45 10.12691/ajbr-4-2-3 AJBR2016423 article Andi Nilawati Usman 1 Yuliana Syam 2 Rosdiana Natzir 3 Sutji Pratiwi Rahardjo 4 Mochammad Hatta hattaram@indosat.net.id 5 Ressy Dwiyanti 6 Yuyun Widaningsih 7 Ainurafiq 8 Prihantono 9 Department of Epidemiology, Health College of RSU Daya, Makassar, Indonesia Department of Nursing, Hasanuddin University, Makassar, Indonesia Department of Biochemistry, Hasanuddin University, Makassar, Indonesia Department of ENT, Faculty of Medicine, Hasanuddin University, Indonesia Department Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Department of Microbiology, Tadulako University, Palu, Indonesia Department of Clinical Pathology, Hasanuddin University, Makassar, Indonesia Department of Chemistry, Hasanuddin University, Makassar, Indonesia Department of Oncology, Hasanuddin University, Makassar, Indonesia Immune balance during infection is important to support both the defense of body immune system and prevent excessive immune response. Protein Foxp3, a transcription factor of regulatory T cell has pivotal roles in balancing body immune system. Honey and Propolis have proved their effects to both the proinflamatory and anti inflammatory responses but their effects to the Foxp3 expression need to be investigated. This study was investigated the effect of giving Trigona honey and honey propolis Trigona to the mRNA Foxp3 expression in Balb/c mice induced Salmonella typhi. Results of the study indicated that honey propolis Trigona had the highest effect to the mRNA Foxp3 expression followed by Trigona honey. Both Trigona honey and honey propolis had immunomodulatory effects through the Foxp3 mRNA expression. http://pubs.sciepub.com/ajbr/4/2/3/ajbr-4-2-3.pdf Trigona Honey Honey Propolis Foxp3