@article{ajbr2016422,
author={{OYEWOLE, Olu Israel and SHOREMI, Mojisola Oluwakemi and OLADELE, Johnson Olaleye},
title={Modulatory Effects of <i>Ricinus Communis</i> Leaf<i> </i>Extract<i> </i>on Cadmium Chloride-Induced Hyperlipidemia and Pancytopenia in Rats},
journal={American Journal of Biomedical Research},
volume={4},
number={2},
pages={38--41},
year={2016},
url={http://pubs.sciepub.com/ajbr/4/2/2},
issn={2328-3955},
abstract={Cadmium (Cd) and its compounds are ubiquitous environmental toxins capable of inducing different types of toxicity in animals and human. <i>R</i><i>icinus communis </i>(castor bean) is a known medicinal plant with enormous health benefits. This study investigated the protective effects of ethanolic leaf<b> </b>extract of <i>Ricinus communis </i>on hyperlipidemia and<i> </i>pancytopenia induced by cadmium chloride in Wistar albino rats. Twenty five (25) adult male rats were divided into 5 groups of 5 rats each. Group A received distilled water, group B, C, D and E were administered 5mg/kg body weight CdCl<SUB>2</SUB>, group C, D and E were treated with 250, 500 and 1000 mg/kg bw respectively of <i>Ricinus communis</i> leaf extract for 14 days while rats in group B were left untreated. Results obtained showed that administration of cadmium<SUB> </SUB>caused significant reduction in cellular elements of the blood (pancytopenia) as well as  increase in the level of serum total cholesterol, triglycerides, LDL-cholesterol and coronary heart disease risk ratio while it decrease the level of HDL-cholesterol. Treatment of rats with graded dose of <i>Ricinus communis</i> leaf extract significantly ameliorate the adverse effects of cadmium as it boosted cellular elements of the blood while it also reduced serum total cholesterol, triglycerides, LDL-cholesterol, coronary heart disease risk ratio as well as elevation of HDL-cholesterol level in the blood. We conclude that leaf extract of <i>Ricinus communis</i> has modulatory effects on cadmium induced pancytopenia and hyperlipidemia in rats.},
doi={10.12691/ajbr-4-2-2}
publisher={Science and Education Publishing}
}