@article{ajbr2016413,
author={{Balogun, Morufu Eyitayo and Nwachukwu, Daniel Chukwu and Salami, Shakiru Ademola and Besong, Elizabeth Enohnyaket and Obu, Dorathy Chinwe and Djobissie, Serges Fankou Athanase},
title={Assessment of Anti-ulcer Efficacy of Stem Bark Extract of <i>Nauclea latifolia </i>(African Peach) in Rats},
journal={American Journal of Biomedical Research},
volume={4},
number={1},
pages={13--17},
year={2016},
url={http://pubs.sciepub.com/ajbr/4/1/3},
issn={2328-3955},
abstract={<b>Aims: </b><i>Nauclea latifolia</i> Sm. (Rubiaceae) is known for its therapeutic uses, especially in alternative medicine.<b> </b>Its leaves, roots and bark have been used traditionally in Nigeria to treat various diseases including ulcer-related diseases. <b>Methods:</b> The aqueous stem bark extract of <i>Nauclea latifolia</i><i> </i>was investigated for anti-ulcerogenic effects using ethanol/HCI and indomethacin as the ulcerogens. The effect of the extract on gastric mucous secretion was also investigated. The extract was administered orally at the doses of 100 and 200 mg/kg b. wt. for the experimental groups while the control and reference groups received distilled water (2 ml/kg, p.o) and omeprazole (20 mg/kg, p.o) respectively. <b>Results:</b> Phytochemical studies revealed the presence of saponins, tannins, alkaloids, terpenes and glycosides. The results show that the extract significantly (p &lt; 0.05) reduced the ulcer index from 4.55 ¡À 1.45 to 1.20 ¡À 0.19 and from 4.20 ¡À 0.72 to 0.94 ¡À 2.51 in the ethanol/HCI and indomethacin induced ulceration respectively. The extract also significantly (p &lt; 0.05) increased the gastric mucous secretion in a dose-dependent manner. <b>Conclusions:</b> The results suggest that the <i>N. latifolia </i>stem bark extract possesses significant anti-ulcer effects which might be due to its ability to increase gastric mucous secretion.},
doi={10.12691/ajbr-4-1-3}
publisher={Science and Education Publishing}
}