eng Science and Education Publishing American Journal of Biomedical Research 2328-3955 2023-10-20 11 1 27 34 10.12691/ajbr-11-1-4 AJBR20231114 article Tchogou Atchad¨¦ Pascal 1 Assou Cendra 1 2 Agbogba F¨¦licienne 2 2 Agniwo Privat 2 Medoatinsa Esp¨¦rance 2 Abissi Yollande 2 Lokonon Jacques Ez¨¦chiel 2 Hlouedje Wilfried 2 Houngbeme Alban 3 Gbenou Joachim 4 Anago Eug¨¦nie 4 Senou Maximin senouxim@yahoo.fr 4 Unit¨¦ de Biologie Exp¨¦rimentale et Clinique (UBEC), Laboratoire de Recherche en Biotechnologie M¨¦dicale et Pharmaceutique (LaRBiMeP), Ecole Nationale Sup¨¦rieure des Biosciences et Biotechnologie Appliqu¨¦es de Dassa-Zoum¨¦ (ENSBBA), Universit¨¦ Nationale des Sciences, Technologies, Ing¨¦nierie et Math¨¦matiques d¡¯Abomey (UNSTIM). Laboratoire National de Pharmacognosie/Centre B¨¦ninois de la Recherche Scientifique et Technique (CBRST). BP 06 Oganla Porto-Novo. Ecole doctorale (ED-STIM), Universit¨¦ Nationale des Sciences, Technologies, Ing¨¦nierie et Math¨¦matiques (UNSTIM). Momordica charantia (M. charantia) is a plant widely used in traditional medicine to treat a number of pathologies, particularly diabetes mellitus. The pharmacological properties of this plant have been demonstrated through the wide variety of its phytochemical components. However, it is very important to know which part of the plant contains the most phytochemical components and biological activity. The aim of this study is to demonstrate the effect on type 1 diabetes in rats and the anti-glycaemic activity of M. charantia ripe fruit extract. Phytochemical screening of ripe fruit was carried out using staining and precipitation reactions. Diabetes was induced in rats by injection of five doses of streptozotocin (40 mg/kg) body weight. Efficacy in animals was tested by treating them with the extracts for 28 consecutive days at 10mg/L. The spectrophotometer and a haematology device were used to assay biochemical and haematological parameters respectively. Histological sections were taken following fixation of pancreas with 10% formalin and staining with hematoxylin-eosin (HE). Five secondary metabolites (alkaloids, reducing compounds, saponosides, triterpenes and steroids) were found in the ripe fruit extract. A weak corrective effect on glycemia, and pancreatic necrosis was demonstrated. A corrective activity on HDL hypocholesterolemia and hypercreatininemia associated with diabetes was also observed. Ripe fruit extract of Momordica charantia displayed a moderate antidiabetic activity. http://pubs.sciepub.com/ajbr/11/1/4/ajbr-11-1-4.pdf diabetes momordica charantia ripe fruit african