@article{ajbr20231114,
author={{Pascal, Tchogou Atchad¨¦ and Cendra, Assou and F¨¦licienne, Agbogba and Privat, Agniwo and Esp¨¦rance, Medoatinsa and Yollande, Abissi and Ez¨¦chiel, Lokonon Jacques and Wilfried, Hlouedje and Alban, Houngbeme and Joachim, Gbenou and Eug¨¦nie, Anago and Maximin, Senou},
title={Efficacy and Antiglycemic Activity of m. Charantia Ripe Fruit in the Correction of Induced Diabetes},
journal={American Journal of Biomedical Research},
volume={11},
number={1},
pages={27--34},
year={2023},
url={http://pubs.sciepub.com/ajbr/11/1/4},
issn={2328-3955},
abstract={<i>Momordica charantia (M. charantia)</i> is a plant widely used in traditional medicine to treat a number of pathologies, particularly diabetes mellitus. The pharmacological properties of this plant have been demonstrated through the wide variety of its phytochemical components.  However, it is very important to know which part of the plant contains the most phytochemical components and biological activity. The aim of this study is to demonstrate the effect on type 1 diabetes in rats and the anti-glycaemic activity of <i>M. charantia</i> ripe fruit extract. Phytochemical screening of ripe fruit was carried out using staining and precipitation reactions. Diabetes was induced in rats by injection of five doses of streptozotocin (40 mg/kg) body weight. Efficacy in animals was tested by treating them with the extracts for 28 consecutive days at 10mg/L. The spectrophotometer and a haematology device were used to assay biochemical and haematological parameters respectively. Histological sections were taken following fixation of pancreas with 10% formalin and staining with hematoxylin-eosin (HE). Five secondary metabolites (alkaloids, reducing compounds, saponosides, triterpenes and steroids) were found in the ripe fruit extract.  A weak corrective effect on glycemia, and pancreatic necrosis was demonstrated. A corrective activity on HDL hypocholesterolemia and hypercreatininemia associated with diabetes was also observed. Ripe fruit extract of <i>Momordica charantia</i> displayed a moderate antidiabetic activity.},
doi={10.12691/ajbr-11-1-4}
publisher={Science and Education Publishing}
}