@article{ajbr2013144,
author={{O., Nwaehujor Chinaka and O., Ode Julius and C., Nwinyi Florence and A., Madubuike Stella},
title={Anticoagulant and Antioxidant Activities of <i>Dracaena </i><i>a</i><i>rborea</i> Leaves (Wild.) Link},
journal={American Journal of Biomedical Research},
volume={1},
number={4},
pages={86--92},
year={2013},
url={http://pubs.sciepub.com/ajbr/1/4/4},
issn={2328-3955},
abstract={The crude methanol extract of <i>Dracaena arborea</i> leaves induced significant (p&lt;0.01) increase in the clotting times of 21 ¡À 0.54 sec and 25 ¡À 1.1 sec at 5% and 10% concentrations of the extract respectively compared to the baseline clotting time of 7 ¡À 0.63 sec for the blood sample. The extract also exhibited potent <i>in vivo</i> and<i> in vitro</i> anticoagulant activities. Increased doses (100 and 200 mg/kg) of the extract, heparin (0.75 and 1.5 mg/kg) and aspirin (1.0 and 2.0 mg/kg) were found to have significantly (p &lt; 0.01) prolonged the mean bleeding times with respect to the baseline in rabbits. However, in thrombin-induced clotting assay, the extract demonstrated a reduced potency compared to heparin. DPPH (1, 1-Diphenyl-2-picrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) spetrophotometric assays revealed that the crude leaf extract possesses appreciable high antioxidant potentials. <i>Dracaena arborea</i> leaves (Wild.) Link could be a source of novel anticoagulant and antioxidant compounds for the management of various hematological disorders.},
doi={10.12691/ajbr-1-4-4}
publisher={Science and Education Publishing}
}