Science and Education Publishing American Journal of Biomedical Research 2328-3955 1 1 2013 10 20 Anticoagulant and Antioxidant Activities of Dracaena arborea Leaves (Wild.) Link 86 92 EN Nwaehujor Chinaka O. Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria Ode Julius O. Nwinyi Florence C. Madubuike Stella A. AJBR2013144 10.12691/ajbr-1-4-4 2013 10 04 2013 10 16 2013 10 20 The crude methanol extract of Dracaena arborea leaves induced significant (p<0.01) increase in the clotting times of 21 ± 0.54 sec and 25 ± 1.1 sec at 5% and 10% concentrations of the extract respectively compared to the baseline clotting time of 7 ± 0.63 sec for the blood sample. The extract also exhibited potent in vivo and in vitro anticoagulant activities. Increased doses (100 and 200 mg/kg) of the extract, heparin (0.75 and 1.5 mg/kg) and aspirin (1.0 and 2.0 mg/kg) were found to have significantly (p < 0.01) prolonged the mean bleeding times with respect to the baseline in rabbits. However, in thrombin-induced clotting assay, the extract demonstrated a reduced potency compared to heparin. DPPH (1, 1-Diphenyl-2-picrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) spetrophotometric assays revealed that the crude leaf extract possesses appreciable high antioxidant potentials. Dracaena arborea leaves (Wild.) Link could be a source of novel anticoagulant and antioxidant compounds for the management of various hematological disorders.