eng Science and Education Publishing American Journal of Biomedical Research 2328-3955 2013-08-02 1 1 75 79 10.12691/ajbr-1-4-2 AJBR2013142 article BENKHASSI Zoubair 1 LAHLOU Fatima Azzahra lahloufz@hotmail.fr 1 HMIMID Fouzia 1 LOUTFI Mohammed 1 BENAJI Brahim 2 BOURHIM Noureddine 2 Biochemistry and Molecular Biology laboratory, Ain Chock Faculty of Science Hassan II University, Casablanca, Morocco Microbiology pharmacology Biotechnology and Environment laboratory, Ain Chock Faculty of Science Hassan II University, Casablanca, Morocco Acetaminophen (Paracetamol) is among the most commonly used analgesic and antipyretic drugs worldwide, itĄ¯s often, but anomalously, classified as non-steroidal anti-inflammatory drugs (NSAIDs) in textbooks of pharmacology . This study aims to evaluate if paracetamol has an antioxidant effect, relative to its analgesic antipyretic and weak anti-inflammatory activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection of peroxide hydrogen (H₂O₂), and then a comparative study is made concerning the activities of the antioxidant enzymes SOD, CAT, and GR as well as lipid peroxidation levels in liver. An increase in SOD, CAT, GR activity and lipid peroxidation in mice treated with H₂O₂ accompanied by paracetamol; compared to the group treated by vitamin C + H₂O₂ showed that acetaminophen doesnĄ¯t show any antioxidant effect. Moreover this study has suggested that acetaminophen induced cytotoxicity in liver mediated by increased oxidative stress and altered redox metabolism. http://pubs.sciepub.com/ajbr/1/4/2/ajbr-1-4-2.pdf acetaminophen (paracetamol) peroxide hydrogen oxidative stress