@article{ajbr2013142,
author={{Zoubair, BENKHASSI and Azzahra, LAHLOU Fatima and Fouzia, HMIMID and Mohammed, LOUTFI and Brahim, BENAJI and Noureddine, BOURHIM},
title={Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen},
journal={American Journal of Biomedical Research},
volume={1},
number={4},
pages={75--79},
year={2013},
url={http://pubs.sciepub.com/ajbr/1/4/2},
issn={2328-3955},
abstract={Acetaminophen (Paracetamol) is among the most commonly used analgesic and antipyretic drugs worldwide, itĄ¯s often, but anomalously, classified as non-steroidal anti-inflammatory drugs (NSAIDs) in textbooks of pharmacology . This study aims to evaluate if paracetamol has an antioxidant effect, relative to its analgesic antipyretic and weak anti-inflammatory activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection of peroxide hydrogen (H<SUB>2</SUB>O<SUB>2</SUB>), and then a comparative study is made concerning the activities of the antioxidant enzymes SOD, CAT, and GR as well as lipid peroxidation levels in liver. An increase in SOD, CAT, GR activity and lipid peroxidation in mice treated with H<SUB>2</SUB>O<SUB>2</SUB> accompanied by paracetamol; compared to the group treated by vitamin C + H<SUB>2</SUB>O<SUB>2</SUB> showed that acetaminophen doesnĄ¯t show any antioxidant effect. Moreover this study has suggested that acetaminophen induced cytotoxicity in liver mediated by increased oxidative stress and altered redox metabolism.},
doi={10.12691/ajbr-1-4-2}
publisher={Science and Education Publishing}
}