Science and Education Publishing American Journal of Applied Mathematics and Statistics 2333-4576 2 3 2014 05 13 On Optimal Weighting Scheme in Model Averaging 150 156 EN Georges Nguefack-Tsague Department of Public Health, University of Yaounde I, Biostatistics Unit, Yaoundé, Cameroon AJAMS2014239 10.12691/ajams-2-3-9 2014 04 14 2014 05 07 2014 05 13 Model averaging is an alternative to model selection and involves assigning weights to different models. A natural question that arises is whether there is an optimal weighting scheme. Various authors have shown their existence in others methodological frameworks. This paper investigates the derivation of optimal weights for model averaging using square error loss. It is shown that though these weights may exist in theory and depend on model parameters; once estimated they are no longer optimal. It is demonstrated using an example of linear regression that model averaging estimators with these estimated weights are unlikely to outperform post-model selection and others model averaging estimators. We provide a theoretical justification for this phenomenon.