American Journal of Medicine Studies

Current Issue» Volume 2, Number 3 (2014)

Article

Alcoholism and Its Relation to Hypoglycemia – An Overview

1Department of Biochemistry, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India

2Department of Biochemistry, Government Medical College, Nagpur, India

3Department of Biochemistry, Manipal University, Manipal, India

4Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India


American Journal of Medicine Studies. 2014, 2(3), 46-49
DOI: 10.12691/ajms-2-3-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Sabitha Kandi, Neelesh deshpande, Pragna rao, K.V. Ramana. Alcoholism and Its Relation to Hypoglycemia – An Overview. American Journal of Medicine Studies. 2014; 2(3):46-49. doi: 10.12691/ajms-2-3-2.

Correspondence to: K.V.  Ramana, Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India. Email: ramana_20021@rediffmail.com

Abstract

Alcohol (ethanol) is metabolized in the liver by enzymes alcohol dehydrogenase and aldehyde dehydrogenase to acetate, which is spontaneously broken down to CO2 and H2O utilizing NAD+ and Cytochrome P450 E1 (CYPE1). Thus alcohol metabolism decreases NAD+ / NADH ratio(redox state). Gluconeogenesis, the synthetic pathway of glucose from non-carbohydrate sources(propionate, lactate, aminoacids, glycerol, alanine) predominantly takes place in liver. The significance of gluconeogenic pathway is that it helps in maintaining blood glucose levels in fasting or starvation conditions. Alcoholism (>120ml /day) leads to an increase in the ratio of NAD+ / NADH, and since the gluconeogenic pathway is dependent on the NAD+ / NADH ratio, increased ratio slows down the pathway leading to hypoglycemia. There is enhanced ketone body metabolism due to hypoglycemia, leading to the accumulation of beta hydroxy butyrate resulting in alcoholic ketosis. Thus alcoholic hypoglycemia and alcoholic ketosis are associated with each other and gross change in liver can be seen after chronic alcoholism with malnutrition. Further studies are required to better understand how liver is able to maintain the redox states longer even during alcoholism.

Keywords

References

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Article

Highlights and Potentials when Using the Visualization Table for Pre-operative Planning and Diagnosis in Seven Surgical and One Oncological Department – A Pilot Study at the University Hospital of Linköping

1Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linköping University, Linköping, Sweden

2Centre for Health Care Development, Clinicum, County Council of Östergötland, University Hospital, Linköping, Sweden

3Sectra Medical Systems AB, Linköping, Sweden


American Journal of Medicine Studies. 2014, 2(3), 42-45
DOI: 10.12691/ajms-2-3-1
Copyright © 2014 Science and Education Publishing

Cite this paper:
Stefan Redéen, Per Elmhester, Roger Larsson, Lisa Lindfors. Highlights and Potentials when Using the Visualization Table for Pre-operative Planning and Diagnosis in Seven Surgical and One Oncological Department – A Pilot Study at the University Hospital of Linköping. American Journal of Medicine Studies. 2014; 2(3):42-45. doi: 10.12691/ajms-2-3-1.

Correspondence to: Stefan  Redéen, Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linköping University, Linköping, Sweden. Email: Stefan.Redeen@lio.se

Abstract

Advances in radiology combined with the advances in computer technology have made the 3D (three-dimensional) representation of anatomic structures easily obtainable using CT and MRI. The data sets resulting from CT and MRI examinations commonly consist of hundreds or thousands of slice images. 3D imaging processes and integrates this image data volume and extracts more meaningful, derivative images via primarily multiplanar reconstruction. The pilot study regards the use of the Visualization Table at Linköping University Hospital. This is one of the first studies including clinical doctors, now being presented by the University Hospital in Linköping, Sweden. Prior experience has shown that the visualization table provides valuable features that improve understanding of the operations field in a new way.

Keywords

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