American Journal of Cancer Prevention

Current Issue» Volume 2, Number 2 (2014)

Article

Dutasteride and Prostate Cancer Risk: Does Family History of Prostate and/or Breast Cancers Influence the Number Needed to Treat? Results from REDUCE

1Surgery Section, Durham VA Medical Center, Durham, NC

2Duke Prostate Center, Division of Urological Surgery, Department of Surgery, Duke, University School of Medicine, Durham, NC

3Division of Urology, Department of Surgery, Memorial Sloan Kettering Cancer Institute

4Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC

5The Arthur Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, NY

6Washington University School of Medicine in St. Louis, St. Louis, Missouri

7Duke Prostate Center, Division of Urological Surgery, Department of Surgery, Duke, University School of Medicine, Durham, NC;Department of Pathology, Duke University School of Medicine, Durham, NC


American Journal of Cancer Prevention. 2014, 2(2), 31-36
DOI: 10.12691/ajcp-2-2-3
Copyright © 2014 Science and Education Publishing

Cite this paper:
Jean-Alfred Thomas II, Leah Gerber, Robert J. Hamilton, Adriana C. Vidal, Daniel M. Moreira, Gerald L. Andriole, Stephen J. Freedland. Dutasteride and Prostate Cancer Risk: Does Family History of Prostate and/or Breast Cancers Influence the Number Needed to Treat? Results from REDUCE. American Journal of Cancer Prevention. 2014; 2(2):31-36. doi: 10.12691/ajcp-2-2-3.

Correspondence to: Stephen  J. Freedland, Surgery Section, Durham VA Medical Center, Durham, NC. Email: Steve.freedland@duke.edu

Abstract

Purpose: In REDUCE, dutasteride was associated with a ~5% absolute reduction in the risk of biopsy-detected prostate cancer (PCa). Material and methods: We tested the influence of family history on the association between dutasteride and PCa diagnosis and calculated the number needed to treat (NNT) with dutasteride to avoid one PCa diagnosis. The REDUCE trial tested dutasteride 0.5mg/day for PCa risk reduction in men aged 50-75 with a serum PSA of 2.5-10.0ng/mL and a negative biopsy. Among men who underwent >1 on-study biopsy with complete data (n=6,415; 78.1%), the association between dutasteride and PCa risk as a function of PCa and/or breast cancer (BCa) family history was examined using multivariable logistic regression. Absolute risk reduction (ARR) and NNT were calculated. Results: On multivariate analysis, dutasteride was significantly associated with lower PCa risk in men without family history (25% lower; p<0.001), PCa family history only (37% lower; p=0.009), or BCa family history only (38% lower; p=0.04). While dutasteride lowered PCa risk in men with both PCa and BCa family history by 15%, this was not significant (p=0.69), though the number of men was small (n=115). ARRs were 6-9% for men with a PCa and/or BCa family history vs. 5% in men with no family history which translated into NNTs of 11-16 in men with PCa and/or BCa family history vs. 21 for men without family history. Conclusion: Using dutasteride as a model of chemoprevention, therapies targeting individuals with specific family histories may improve the risk-benefit profile. However, future studies are warranted to confirm our findings.

Keywords

References

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Article

Genetic Testing for Risk of Lung Cancer: A Pilot Study Examining Perceived Benefits and Barriers using Health Belief Model

1Division of Social and Administrative Sciences in Pharmacy, Oscar Rennebohm School of Pharmacy, University of Wisconsin-Madison

2Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York City

3School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, Georgia


American Journal of Cancer Prevention. 2014, 2(2), 24-30
DOI: 10.12691/ajcp-2-2-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Karishma Desai, Bupendra Shah, Hamid Rahim, Hongjun Yin, John Lonie. Genetic Testing for Risk of Lung Cancer: A Pilot Study Examining Perceived Benefits and Barriers using Health Belief Model. American Journal of Cancer Prevention. 2014; 2(2):24-30. doi: 10.12691/ajcp-2-2-2.

Correspondence to: Karishma  Desai, Division of Social and Administrative Sciences in Pharmacy, Oscar Rennebohm School of Pharmacy, University of Wisconsin-Madison. Email: desaikaru@gmail.com

Abstract

Aim: To (i) assess participants’ awareness of the availability of genetic testing to determine the risk of different types of cancer; (ii) to assess participants’ beliefs about genetic testing for the risk of lung cancer using Health Belief Model; and (iii) to explore factors affecting intention to use genetic testing for risk of lung cancer. Methods: A sample of 360 New Jersey residents were surveyed by interviewers from three densely populated cities in the northern, central and southern regions of New Jersey. The survey instrument was developed using the Health Belief Model and measures were adapted from the literature. Descriptive statistics and regression analyses were used to examine factors associated with intention to use genetic testing. Results: A total of 360 individuals were surveyed in three cities in New Jersey. Of these, 50% were non-Hispanic White, female, and with an annual income of less than $50,000; 66% were nonsmokers without a family history of lung cancer. The overall intention to use the genetic test to determine lung cancer risk was low (35%), even though the majority of participants believed genetic testing for lung cancer to be highly beneficial, and despite believing it to be a severe condition [M(SD)=11.5(2.3)}. Approximately 50% of participants were aware of the availability of genetic tests for the risk of lung cancer, and respondents believed they were moderately susceptible to lung cancer [M(SD)=25.3(3.7)].Gender, education, smoking habits and perceived benefits of testing were significant predictors of intention. Conclusion: Awareness and intention to use genetic testing for the risk of lung cancer was low. This study provides useful information for healthcare professionals interested in promoting the use of genetic testing for at-risk populations such as smokers, and how to tailor interventions.

Keywords

References

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Article

Awareness and Knowledge of Smoking-Related Cancers Among University Students in Jordan

1Faculty of Medicine, University of Jordan, Amman, Jordan


American Journal of Cancer Prevention. 2014, 2(2), 20-23
DOI: 10.12691/ajcp-2-2-1
Copyright © 2014 Science and Education Publishing

Cite this paper:
Ayoub A. Innabi, Dina A. Ammari, Wa'el J. K. Tuqan. Awareness and Knowledge of Smoking-Related Cancers Among University Students in Jordan. American Journal of Cancer Prevention. 2014; 2(2):20-23. doi: 10.12691/ajcp-2-2-1.

Correspondence to: Ayoub  A. Innabi, Faculty of Medicine, University of Jordan, Amman, Jordan. Email: ayoubinnabi@yahoo.com

Abstract

Background: Jordan, a Middle Eastern country, has a high prevalence rate of smoking. However, little research was done to evaluate knowledge of smoking-related cancers in the region. Objective: To assess knowledge of smoking-related cancers among Jordanian university students. Design: Cross-sectional study conducted in July, 2013, using a self-administered online questionnaire. The questionnaire was sent to students from University of Jordan. Results: The final sample consisted of 230 students. The majority of participants (98.7%) were aware that smoking has harmful health effects and (95.7%) agreed that smoking causes cancer. Most of the participants agreed that smoking causes lung cancer (97.8%), oral cancer (83.0%), laryngeal cancer (82.6%), pharyngeal cancer (80.0%), and esophageal cancer (63.0%), while less than half of the participant thought that smoking causes AML (46.1%), stomach cancer (36.1%), kidney cancer (32.6%), cervical cancer (19.6%), pancreatic cancer (19.1%), and bladder cancer (14.8%). Females showed more knowledge about smoking-related cancers than males (p < 0.05) but the there was no significant difference between smokers and non-smokers. Conclusion: These findings show that most of the students know that lung cancer is caused by smoking. However, there is a lower knowledge of other smoking-related cancers. Our study suggests that more efforts should be done to increase the awareness of the adverse health hazards of smoking especially that are related to cancer.

Keywords

References

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