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American Journal of Cancer Prevention

ISSN (Print): 2328-7322

ISSN (Online): 2328-7314

Website: http://www.sciepub.com/journal/AJCP

Current Issue» Volume 3, Number 1 (2015)

Article

Different Presentation of Treatment in Carcinomatous Meningitis of Breast Cancer: Report of 3 Cases

1Department of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran


American Journal of Cancer Prevention. 2015, 3(1), 4-7
DOI: 10.12691/ajcp-3-1-2
Copyright © 2015 Science and Education Publishing

Cite this paper:
Mehrdad Payandeh, Edris Sadeghi, Masoud Sadeghi, Akram Mozafari Eskandar. Different Presentation of Treatment in Carcinomatous Meningitis of Breast Cancer: Report of 3 Cases. American Journal of Cancer Prevention. 2015; 3(1):4-7. doi: 10.12691/ajcp-3-1-2.

Correspondence to: Edris  Sadeghi, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email: sadeghi_mkn@yahoo.com

Abstract

Background: Carcinomatous Meningitis (CM) refers to the multifocal seeding of the leptomeninges by malignant cells. CM occurs in approximately 5% of patients with breast cancer. Herein, we suggest that Intrathecal (IT) can use in treatment of breast cancer patients with CM before of any treatment until can prevent of going patient to debilitating phase of this disease. Patients and Methods: Three patients with high risk breast cancer with CM: A 62 year-old Kurdish woman with a history of lung tuberculosis. Her cerebrospinal fluid was positive for malignant cells. She treated with IT chemotherapy and died 3 months after diagnosis of CM. A 48 year-old woman in premenopausal states had a left axillary mass for last 4 months. After one year of followed up she complaints with refractory headache. In cerebrospinal fluid (CSF) analysis with diagnosis of CM treated with brain irradiation and multiple courses of IT chemotherapy. After six months she is well still and in follow up with previous drug list and monthly IT chemotherapy. A 63 year-old woman was presented at the emergency department of our hospital. After 4 months of her treatment she complained from decrease of consciousness and in CSF analysis with positive cytology. She treated with IT chemotherapy and She died about 2 weeks ago with exacerbation of brain tumor. Conclusion: According to the poor prognosis of this disease it is better that in high risk breast cancer patients like Non-Hodgkin lymphoma (NHL) high risk patients. IT prophylaxis was done for these high risk patients because by this way, we can prevent of going patient to debilitating phase of this disease.

Keywords

References

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Article

Type of Treatment Can Effect on Transformation of Chronic Lymphocytic Leukaemia to Diffuse Large B-cell Lymphoma: A Rare Case with Review of Literature

1Department of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


American Journal of Cancer Prevention. 2015, 3(1), 1-3
DOI: 10.12691/ajcp-3-1-1
Copyright © 2015 Science and Education Publishing

Cite this paper:
Mehrdad Payandeh, Masoud Sadeghi, Edris Sadeghi, Seyed Hamid Madani. Type of Treatment Can Effect on Transformation of Chronic Lymphocytic Leukaemia to Diffuse Large B-cell Lymphoma: A Rare Case with Review of Literature. American Journal of Cancer Prevention. 2015; 3(1):1-3. doi: 10.12691/ajcp-3-1-1.

Correspondence to: Masoud  Sadeghi, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email: sadeghi_mbrc@yahoo.com

Abstract

Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL) is the most common type of richter syndrome. Herein, we describe report of a 51 year-old man in western Iran that referred to Hematology Clinic with complaint of three months of weight loss and sweating with generalized abdominal lymphadenopathy and the Bulky cervical lymph node. Pathology’s specimens for him demonstrated CLL in the patient (Rai system stage 4) and during seven years ago, he was treated with fludarabine and cyclophosphamide regiment for 6 courses. Cervical biopsy pathology reported a new diagnosis of diffuse large B-Cell lymphoma and also immunohistochemistry (IHC) analysis showed CD3, CD20, CD45 were positive and Bcl-2 was negative and so he was treated with new regiment of R-CHOP for 6 courses. One month after last course of chemotherapy, Cerebrospinal fluid cytology was positive with lymphomatous involvement, and also brain CT SCAN showed parenchymal involvement and therapy with high dose Methotrexate began for him. The result is that specialists should be careful that probably fludarabin therapy alone or combination it with other drug especially cyclophosphamide can effect on transformation CLL to DLBCL.

Keywords

References

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