The systemic lupus erythematous (SLE) is a multisystemic autoimmune disease. It is a remitting and relapsing illness of variable presentation and course. It is frequent all over the world with predominance in adult women.
Although recent studies suggest the role of immunological, genetic and environmental factors, its pathogenesis remains unclear.
Its clinical features are variable from fever to life-threatening complications (pancreatitis, seizure, pericarditis, nephritis..). Thus, its diagnosis remains difficult despite of the evolution of our knowledge of the disease. Many recent studies have developed the SLE diagnosis criteria.
Because of its so various symptoms, the management of this disease needs collaboration of different experts (Internist, Rheumatologist, Nephrologists, Neurologists, Immunologists..).
The Treatment of SLE continues to be difficult although many clinical trials. Several scientific societies such European League Against Rheumatism (EULAR) and Amecrican College of Rheumatology have published guidelines for the SLE. Despite their important contribution to better quality of the disease management, the SLE can sometimes have poor prognosis especially in renal, cardiovascular and neurological involvement.
This special issue aims:
- To study the most important aspects of SLE focusing on epidemiology, different disease manifestations and diagnostic criteria.
- To evaluate different therapeutic approaches, including the biologic agents,
- To explore the disease outcomes and study the different factors influencing the SLE syndrome evolution.