Welcome to American Journal of Cardiovascular Disease Research

American Journal of Cardiovascular Disease Research is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of Cardiovascular Disease. The aim of the journal is to provide researchers and practitioners a platform to share cutting-edge development in the field of Cardiovascular Disease.

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Editor-in-Chief: Dario Galante

Website: http://www.sciepub.com/journal/AJCDR

   

Article

Comparative Study of Hypothyroidism with Cardiometabolic Risk

1Lab incharge, Apollo Reach Hospital, Karimnagar, Telangana, India

2Department of Biochemistry, Chalmeda Ananda Rao Institutue of Medical sciences, Karimnagar, Telangana, India

3Department of Biochemistry, Prathima Institute of Medical sciences, Karimnagar, Telangana, India

4Department of Microbiology, Prathima Institute of Medical sciences, Karimnagar, Telangana, India


American Journal of Cardiovascular Disease Research. 2015, 3(1), 1-4
doi: 10.12691/ajcdr-3-1-1
Copyright © 2015 Science and Education Publishing

Cite this paper:
T Sudhakar, Sabitha Kandi, B Venugopal, K. Bhagwan Reddy, K V Ramana. Comparative Study of Hypothyroidism with Cardiometabolic Risk. American Journal of Cardiovascular Disease Research. 2015; 3(1):1-4. doi: 10.12691/ajcdr-3-1-1.

Correspondence to: K  V Ramana, Department of Microbiology, Prathima Institute of Medical sciences, Karimnagar, Telangana, India. Email: ramana_20021@rediffmail.com

Abstract

Hypothyroidism is a thyroid deficient state which shows its influence on other metabolic pathways whereas sub-clinical hypothyroidism (SCH) is a condition where there is decreased secretion of Thyroid Stimulating Hormone (TSH) with no significant clinical symptoms. Thyroid hormones (T3, T4 and TSH) play an effective role in various aspects of metabolism, development and differentiation of cells. In the present study which included 558 male subjects who came for regular health checkup, 68 (12.18%) were newly diagnosed as suffering from hypothyroidism and among them, 27 (4.83%) had altered lipid parameters. The presenting symptoms included unknown cause of fatigue and weight gain. The atherogenic lipid abnormalities in subjects with hypothyroidism in Indians should be interpreted with paramount importance as there is unexpected improvement or worsening of their lipid profile which may be influenced by abnormal thyroid hormone secretion. The altered lipid profile is seen in conditions where TSH is more than 10 mIU/ml which can result in increased risk of cardiac diseases and altered hemodynamic states. Alcoholism, smoking, sedentary life style, genetic predisposition and stress are added factors to earlier onset of SCH. The important aspects in management of thyroid diseases include the public health awareness, regular screening for the presence of dyslipedemia and thyroid function tests.

Keywords

References

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Article

Risk Factors of Peripartum Cardiomyopathy and the Important Role of Prenatal Care

1Department of Cardiology and Vascular Medicine, Padjadjaran University, Jalan Eijkman 38, Bandung 40161, Indonesia


American Journal of Cardiovascular Disease Research. 2015, 3(1), 5-8
doi: 10.12691/ajcdr-3-1-2
Copyright © 2015 Science and Education Publishing

Cite this paper:
Hawani Sasmaya Prameswari, Augustine Purnomowati, Toni Mustahsani Aprami. Risk Factors of Peripartum Cardiomyopathy and the Important Role of Prenatal Care. American Journal of Cardiovascular Disease Research. 2015; 3(1):5-8. doi: 10.12691/ajcdr-3-1-2.

Correspondence to: Hawani  Sasmaya Prameswari, Department of Cardiology and Vascular Medicine, Padjadjaran University, Jalan Eijkman 38, Bandung 40161, Indonesia. Email: hawanisasmaya@gmail.com

Abstract

Peripartum cardiomyopathy (PPCM) is one of dilated cardiomyopathy of unknown cause. The aim of this study is to determine the risk factors and the importance of prenatal care (PNC). This is a descriptive and analytical study with Chi Square test of PPCM cases collected from medical records January 1, 2011 through December 31, 2013 in the Dr.Hasan Sadikin Central General Hospital as the top-referral hospital of West Java Province. We collected 57 PPCM cases (18.7%) of 305 pregnant women or 6 months postpartum with cardiovascular problems. Distribution of PPCM cases decreased significantly (p= 0.002) from 2011 (27 patients), 2012 (16 patients), and 2013 (14 patients), with average age 30.3 (±7.9) years, cesarean delivery (43.8%), pervaginal (37.5%), forceps (15%), and vacuum-extractor (3.8%). Regular prenatal care was 84.20%. Lower socioeconomic patients were 63.2%, therefore the issue of welfare can lead to vulnerability to PPCM. Confirmed diagnosis using echography made during postpartum was 52.63% and antepartum was 47.5%. Preeclampsia was 43.80% (p=0.007) mostly NYHA functional class IV (86.30%). Echocardiography was performed on 57 patients have average ejection fraction 34.8%, global hypokinetic in 98.27% patients, 39.6% with all cardiac chamber dilatation, left atrium and left ventricle dilation in 34.48%, and 25.86% with left ventricular dilatation. The hospital based prevalence was 18.68%, with the majority (84.20%) was NYHA functional class IV. The significant risk factors were age over 30 years, multiparous, low socioeconomic, and preeclampsia. This study is probably the first report mentioning a high prevalence of PPCM in Indonesia. This report provides an awareness of PPCM during PNC to prevent the morbidity and mortality. PPCM disorder requires regular and careful PNC by taking into account existing risk factors is the key that is required and must be held in every health centre.

Keywords

References

[1]  Sliwa K,Hilfiker-Kleiner D,Petrie MC,Mebazaa A,Pieske B,Buchmann E, et al. Current State of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur Heart J. 2010; 12: 767-78.
 
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[3]  Rmaraj K, Sorrel VL. Peripartum cardiomyopathy: Causes, diagnosis, and treatment. Cleve Clin J Med. 2009; 76 (5): 289-96.
 
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Article

“Requiring Intravenous Nitroglycerin” Should be considered a High Risk Feature in Patients with Non-ST Elevation Myocardial Infarction and Unstable Angina

1Department of Medicine, Harlem Hospital Center in affiliation with Columbia University Medical Center New York, NY 10037

2Division of Cardiology, Department of Medicine, Harlem Hospital Center in affiliation with Columbia University Medical Center New York, NY 10037


American Journal of Cardiovascular Disease Research. 2015, 3(1), 9-12
doi: 10.12691/ajcdr-3-1-3
Copyright © 2015 Science and Education Publishing

Cite this paper:
Olusegun Sheyin, Melissa Fajardo, Oladapo Igandan, Bredy Pierre-Louis. “Requiring Intravenous Nitroglycerin” Should be considered a High Risk Feature in Patients with Non-ST Elevation Myocardial Infarction and Unstable Angina. American Journal of Cardiovascular Disease Research. 2015; 3(1):9-12. doi: 10.12691/ajcdr-3-1-3.

Correspondence to: Olusegun  Sheyin, Department of Medicine, Harlem Hospital Center in affiliation with Columbia University Medical Center New York, NY 10037. Email: oas2120@columbia.edu

Abstract

Introduction: Early risk stratification of patients with unstable angina (UA) and non-ST elevation myocardial infarction (NSTEMI) is crucial to identify those at high risk for further cardiac events as they may benefit from an early invasive strategy of coronary angiography and revascularization. The TIMI score, a widely used predictive model to guide management strategy in UA and NSTEMI may not accurately stratify risk. Case description: A 63-year-old man, who is an active smoker with past medical history of hypertension and dyslipidemia, presented with severe sub-sternal, crushing chest pain, which began four hours prior to presentation. His EKG revealed sinus tachycardia, without ST segment deviations or Q waves. He received aspirin, three doses of sublingual nitroglycerin and metoprolol, but continued to have chest pain, thus he was commenced on intravenous nitroglycerin infusion. His chest pain went away after two hours on nitroglycerin infusion. His initial serum troponin I was 0.31 ng/mL and 3.60 ng/mL four hours after presentation. He was admitted for NSTEMI and started on clopidogrel, atorvastatin and intravenous heparin. Echocardiogram revealed inferio-septal wall a kinesis and severely reduced left ventricular systolic function. His troponin I continued to rise, peaking at 37.4 ng/mL. He was started on eptifibatide and was referred for coronary angiography and percutaneous coronary intervention, with finding of fifty percent proximal and distal left anterior descending artery (LAD) lesions. Discussion: With a TIMI score of 2, our patient was classified as low risk at presentation. The need for intravenous nitroglycerin infusion for continuing chest pain in the management of UA or NSTEMI may suggest a greater degree of myocardial ischemia and a higher risk for adverse cardiovascular outcomes. This case demonstrates that UA and NSTEMI patients requiring intravenous nitroglycerin initially planned for conservative therapeutic approach need continuous risk stratification which may dictate a change to the invasive management strategy.

Keywords

References

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