Special Issue Call for Papers

American Journal of Biomedical Research

Special Issue Call for Papers

Special Issue on Vaccines and delivery system

Vaccines are the most successful discoveries of biomedical sciences. Due to the lack of enough funding available to vaccine research and the lack of knowledge regarding how do they work in the cellular and molecular level, we do not have successful vaccines against major killer of the human population. These major killers are HIV, malaria, and TB. So, understanding the mechanisms of action of vaccines and vaccine adjuvants on the cellular and molecular level would allow us designing new vaccines against these major killers. Collecting the global literatures, manuscript, understandings and lab results will be contributing factors in enhancing vaccine science.

About the issue

The topics of this special issue include, but are not limited to:

  • Human and animal vaccines-communicable/non-communicable diseases
  • Veterinary vaccines
  • Immunology of vaccines
  • Adjuvants and drug delivery system
  • Animal model in vaccine research

Important dates

Submission Deadline: December 29, 2014
Notification of Acceptance: March 30, 2015
Final Version Due: April 30, 2015
Special Issue Publishing Date: May 30, 2015

Chief Guest Editor

Dr. Tirth Ghimire
Division of Veterinary Health, Global Primate Network, Nepal.
Email: tirtha@primatelife.org

Submit your article now

Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Dr. Tirth Ghimire at the address: <tirtha@primatelife.org>

Special Issue on The Molecular Mechanisms of Regulatory T Cell Immunosuppression

There is an emerging consensus that elevated levels of intracellular cyclic adenosine monophosphate (cAMP) in naturally occurring regulatory T (nTreg) cells may play a key role in nTreg-cell-mediated suppression. During suppression nTreg cells unable to flux Ca2+ upon T cell receptor (TCR) engagement harbor high ‘supraphysiological’ levels of intracellular cAMP by direct binding of Foxp3 to the phosphodiesterase 3b (Pde3b) gene along with downregulation of miR-142-3p, which silences adenylyl cyclase (ADCY9) mRNA also leading to upregulated cAMP production in nTreg cells. Upon contact elevated cAMP levels in nTreg cells are transferred to activated conventional CD4+ T cells (Tcons) via cell contact dependent gap junction intercellular communications (GJIC). Various cell types including T cells may have GJIC formed by Cx43/ZO-1/Ezrin/Protein kinase A (PKA) supramolecular complex where ezrin targeted PKA by phosphorylation of Cx43 controls its opening and closing. However, cAMP increase in inducible Tregs (iTregs) or Tcons could be also receptor-mediated and is operated by various agonists such as prostaglandin E2 (PGE2), adenosine, histamine, serotonine, or adrenergic stimulation, and/or using agonists recognizing CD39/CD73 receptors. Furthermore, phosphodiesterases (PDEs) such as PDE3b can modulate cAMP both on the nTreg as well as Tcon side by exploiting proximal PKA-Csk pathway. Thus, cAMP-dependent signaling can trigger multifaceted molecular mechanisms acting directly as well as indirectly on transcriptional attenuation of interleukin – 2 (IL-2) synthesis in T cons. These events affect interplay of cAMP and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER) and its suppression of nuclear factor of activated T cell (NFAT)-mediated synthesis of IL-2. In addition to its suppressive effects mediated via ICER, cAMP can also modulate the levels of surface-expressed cytotoxic T lymphocyte antigen-4 (CTLA-4) and its cognate B7 ligands on Tcons and/or antigen presenting cells (APCs), fine-tuning suppression. Thus, this Research Topic is focused on articles that can shed some new light on the cAMP-mediated mechanisms responsible for nTreg-mediated immunosuppression of IL-2 synthesis.

About the issue

The scope of topics covered in the this issue include:

  • CD4+ T cells
  • Regulatory T (Treg) cells
  • Gene regulation
  • Costimulatory Molecules
  • Signal transduction

Important dates

Submission Deadline: September, 2014
Notification of Acceptance: October, 2014
Final Version Due: November, 2014
Special Issue Publishing Date: December, 2014

Chief Guest Editor

Josef Bodor
Institute of Experimental Medicine, Academy of Sciences of Czech Republic, EU Centre of Excellence
Email: josef.bodor@biomed.cas.cz

Submit your article now

Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Josef Bodor at the address: <josef.bodor@biomed.cas.cz>