American Journal of Biomedical Research
Mitochondria are the energy (ATP) storage tanks of a cell and constant supply of energy is essential for various cellular functions. Mitochondria has its own genome that encodes 37 genes of which 13 encode essential components of oxidative phosphorylation (OXPHOS), 22 encode tRNA genes, 1 for 12s and 1 for 16s tRNA required for mitochondrial encoded protein synthesis. Unlike nuclear genome, mitochondrial genome is highly prone to mutations and damage because they are located at close proximity to the site of free radical production. Since most of the energy demanding organs and cells such as brain, skeletal muscle, heart, sperm, and ovum require extensive energy for their normal functions, any defects in ATP production will lead to an early manifest of the disease or disorders. Most of the mitochondria disorders are non curable and hence more studies are needed to explore the possible treatments. On the other hand mitochondria also plays an important role in the cancer progression either by supplying energy demanded by the cancer cell or modify themselves to evade from apoptosis. Till date there are very few studies on targeting mitochondria in various disorders and diseases. Therefore, the aim of this special issue is to explore the understanding of pathological role of mitochondria in various diseases and disorders which will aid in the development of new potential therapeutics targeting mitochondria.
About the issue
The scope of topics covered in the this issue include:
Submission Deadline: March, 2015Notification of Acceptance: May, 2015Final Version Due: July, 2015Special Issue Publishing Date: August, 2015
Chief Guest Editor
Venkatesh SundararajanNew Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USAEmail: email@example.com
Guest EditorAlok PandeyNew Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USAEmail: firstname.lastname@example.org
Submit your article now
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Venkatesh Sundararajan at the address: <email@example.com>
or through the journal’s Paper Submission System.
The bioinformatics and computational genomics special issue aims to promote the application of new and/or existing computational methods to the high throughput data to unravel biological and biomedical findings.
High-throughput bio-analytical technologies such as DNA sequencing and micro-arrays have revolutionized biomedical research. Computational and biostatistical methods, in particular the field of data mining had an important impact too. As wealth of data is constantly generated from bioanalytical assays, appropriate methods, algorithms, software and applications have been widely used to derive in-silico results that should be confirmed by biological interpretation. This special issue therefore intends to highlight the interesting, novel and sound results that are successfully generated by the application of data mining to the biomedical data. While the scope of manuscripts can be very large in biomedical genomics research, translational research is of particular area of interest.
As this issue is multi-disciplinary, it accepts different types of articles including but not limited to review, research article, software, application, methods and algorithms.
Submission Deadline: March 31, 2015Notification of Acceptance: April 30, 2015Final Version Due: May 30, 2015Special Issue Publishing Date: June 30, 2015
Haleh YasrebiUniversity of GenevaEmail: firstname.lastname@example.org
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Haleh Yasrebi at the address: <email@example.com>
Biomedical Research is a very broad description for work that may involve biology, chemistry, physics, physiology, genetics, statistics and a host of other disciplines. This might include the development of a simple first mercury thermometer in 1714 by Gabriel Fahrenheit to the construction of complex 3 Tesla Magnetic Resonance Imaging (MRI). Despite such major technological transformation, innovation still doesn’t retard. An innovative biomedical system gives us a new insight regarding the development of new technologies & engineering solutions to mitigate health-related problems especially in the developing countries.
Nanotechnology, the hot cake in the present biomedical research, where the structures, devices and systems are reduced to nanoscale has gained wide acceptance for health benefits including early disease detection (use of sensors), controlled drug delivery using nanospheres and moieties, nanofibers for tissue engineering applications, energy harvesting, solar cells and so on.
Emphasizing various areas of interdisciplinary expertise, this special issue will assimilate biomedical considerations & contents- such as development of smart biomaterials, drug delivery systems that mimics both the structural and functional integrity to that of natural materials and biomimetic tissue engineered scaffolds for the orthopedic as well as cardiovascular applications.
Thus, this issue shall prove to be a boon in the context of biomedical engineering to know, understand &develop the technical competencies for modeling, designing and developing any complex biomedical systems.
Submission Deadline: December 29, 2014Notification of Acceptance: February 01, 2015Final Version Due: February 28, 2015Special Issue Publishing Date: March 20, 2015
Vishwa Prakash ShrivastavaPrincipal, College of Biomedical Engineering & Applied Sciences, Kathmandu, NepalVice-President, Society for Biomaterials & Artificial Organs (SBAOI), IndiaEmail: firstname.lastname@example.org
Guest EditorUma ShrivastavaVice-principal, College of Biomedical Engineering & Applied Sciences, Kathmandu, NepalFounder, Reproductive Endocrinologist, Infertility Centre NepalEmail: email@example.com
Pravin BhattaraiBiomedical Engineer, National Public Health Laboratory (NPHL), Department of Health Services, Ministry of Health & PopulationEmail: firstname.lastname@example.org
Keshar Bahadur ThapaBiomedical Engineer, National Public Health Laboratory (NPHL), Department of Health Services, Ministry of Health & PopulationEmail: email@example.com
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Vishwa Prakash Shrivastava at the address: <firstname.lastname@example.org>
The special issue will have the aim to cover current concepts regarding the essential role of endothelial cells in pancreas organogenesis and function. Although this concept was described for the first time about fourteen years ago, the crucial importance of endothelial cells for tissue differentiation and organ function has been recently recognized. Therefore, the concepts have to be re-reviewed for accuracy. In addition, it has been suggested that endothelial cells are essential for maintenance of adequate function in organs such as pancreas and in particular pancreatic beta cells that compose the islet of Langerhans that is relevant in Regenerative Medicine. The scope will include: (1) Current concepts about pancreas organogenesis including novel transcription factors that have been discovered and are crucial for adequate exocrine and endocrine pancreas differentiation. (2) The detailed composition of the pancreatic niche including the vascular component. (3) The endothelial signaling for pancreas differentiation and cellular maturation. (4) The endothelial signaling for pancreas regeneration in situ and in vitro. (5) The endothelial signaling for pancreatic beta-cell function. (6) The endothelial signaling to design a functional artificial pancreas. Therefore the general scope involves the endothelial signaling involved in the development of a functional pancreas.
Submission Deadline: December 10, 2014Notification of Acceptance: January 30, 2015Final Version Due: February 20, 2015Special Issue Publishing Date: March 30, 2015
Dodanim Talavera-AdameCedars-Sinai Medical CenterEmail: Talaverad@cshs.org
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Dodanim Talavera-Adame at the address: <Talaverad@cshs.org>
There is an emerging consensus that elevated levels of intracellular cyclic adenosine monophosphate (cAMP) in naturally occurring regulatory T (nTreg) cells may play a key role in nTreg-cell-mediated suppression. During suppression nTreg cells unable to flux Ca2+ upon T cell receptor (TCR) engagement harbor high ‘supraphysiological’ levels of intracellular cAMP by direct binding of Foxp3 to the phosphodiesterase 3b (Pde3b) gene along with downregulation of miR-142-3p, which silences adenylyl cyclase (ADCY9) mRNA also leading to upregulated cAMP production in nTreg cells. Upon contact elevated cAMP levels in nTreg cells are transferred to activated conventional CD4+ T cells (Tcons) via cell contact dependent gap junction intercellular communications (GJIC). Various cell types including T cells may have GJIC formed by Cx43/ZO-1/Ezrin/Protein kinase A (PKA) supramolecular complex where ezrin targeted PKA by phosphorylation of Cx43 controls its opening and closing. However, cAMP increase in inducible Tregs (iTregs) or Tcons could be also receptor-mediated and is operated by various agonists such as prostaglandin E2 (PGE2), adenosine, histamine, serotonine, or adrenergic stimulation, and/or using agonists recognizing CD39/CD73 receptors. Furthermore, phosphodiesterases (PDEs) such as PDE3b can modulate cAMP both on the nTreg as well as Tcon side by exploiting proximal PKA-Csk pathway. Thus, cAMP-dependent signaling can trigger multifaceted molecular mechanisms acting directly as well as indirectly on transcriptional attenuation of interleukin – 2 (IL-2) synthesis in T cons. These events affect interplay of cAMP and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER) and its suppression of nuclear factor of activated T cell (NFAT)-mediated synthesis of IL-2. In addition to its suppressive effects mediated via ICER, cAMP can also modulate the levels of surface-expressed cytotoxic T lymphocyte antigen-4 (CTLA-4) and its cognate B7 ligands on Tcons and/or antigen presenting cells (APCs), fine-tuning suppression. Thus, this Research Topic is focused on articles that can shed some new light on the cAMP-mediated mechanisms responsible for nTreg-mediated immunosuppression of IL-2 synthesis.
Submission Deadline: September, 2014Notification of Acceptance: October, 2014Final Version Due: November, 2014Special Issue Publishing Date: December, 2014
Josef BodorInstitute of Experimental Medicine, Academy of Sciences of Czech Republic, EU Centre of ExcellenceEmail: email@example.com
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Josef Bodor at the address: <firstname.lastname@example.org>
Human body is genetically controlled and environmentally modulated. The aim of the special issue is to establish the foundation for eradication of the invincible factor of the diseases by systematic development of novel mind of coming generation by Spirit wisdom, Devotion, Modern Yoga & Founder Science, Vedas, Puranas and genuine scripture. In very brief human materialistic body is absolutely governed by invincible and invisible causing agents of diseases of Mind beyond DNA. Sincerely, as a philosopher, I like to introduce spirit with great enthusiasm with novel discovery of remedies for eradication of ignorance and its six councilors as Lust, Anger, Greed, Pride, Jealous and Infatuation (http://pubs.sciepub.com/ajbr/2/2/2/). In this, my approach is to introduce the theory of Evenness and motivate the scientists to lamp the light of spiritual wisdom in existing modern science. In this, under pure and limpid state of my mind, I come to conclusion that that maternal mental state is prime important to produce novel thinker. According to definition of basic science Zoology & Social-Science, A Man is a just well develop social animal only. Manipulation in genetic pool is a partially promising tool to eradicate a short of deficiency of diseases. In current scenario of world environment, where utmost people are living under causing a lot of stress, which is the root cause of potential disorder of mind. Anger, those are current picture of maximum woe is beyond the limit of materialistic science. All together, these traits are causing innumerable metal disorders and ultimately reduce human age. There are many more fell diseases, too numerous to mention. The founder science Vedas and religious scriptures described several paths to reduce the above said invincible cause of dangerous mental disorder. In this special issue, I especially along with other colleagues interested to publish the research work from around the globe for public to reduce the invincible factors diseases of mind by spirit, devotion, modern yoga, ayurveda and spiritual wisdom. This approach will definitely lead to enhance humane age by implementing the doctrine of humanity. So that we could reduce the demonic/terrorist activity and ultimately the world will move towards Doctrine, Health & Peace. In very brief, after competition of several successful projects as President, Director, Distinguished Scientist and so many respectable positions, Currently, I am working as Philosopher in the laboratory of Nature at RAMA Center, for eradication of mental and psychological diseases. Thus, I sincerely like welcome, encourage & invite entire novel intellectual scientist, Seers, Saints, Sages, Adepts, Preceptors, Theosophists, Men of Religions and Philosophy to submit their articles to exchange the vision and mission for future science. I consider this will be pure & limpid contribution of scientists for Ultimate Human Welfare (UHW) that is peace.
Submission Deadline: September 15, 2014Notification of Acceptance: November 15, 2014Final Version Due: November 30, 2014Special Issue Publishing Date: December 31, 2014
Dr. Ravi S. PandeyRAMA-Prema-Sadan, Belvan Mirzapur UP IndiaSatya Dham RAMA World center of Truth & Peace IndiaWorld Health Piety and Peace Center IndiaUniversity of Missouri Columbia, USAMahima Research Foundation and Social Welfare BHU Varanasi IndiaEmail: email@example.com
Guest EditorDr. Sanjiv K. BhattacharyaKyoto University, Kyoto, JapanBARC Mumbai, IndiaMayo Clinic, Rochester, MN USAUniversity of Missouri Columbia, USAHarvard Medical School Boston USASatya Dham RAMA World center of Truth & Peace IndiaEmail: Sanjibkumar08@gmail.com
Dr. Birendra K. Singh RajputTextile Rubber & Chemical Co IndiaDalton, Georgia, USASatya Dham RAMA World center of Truth & PeaceEmail: firstname.lastname@example.org
Ratnesh K. RaoMahima Research Foundation and Social Welfare BHU Varanasi IndiaEmail: email@example.com
Dr. Anuraag SupakarRAMA-Prema-Sadan, Belvan Mirzapur IndiaEmail: firstname.lastname@example.org
Dr. Shweta SharmaRAMA-Prema-Sadan, Belvan Mirzapur IndiaEmail: email@example.com
Colleagues & Sub-editorSharmila Supakar, Prema Devi, Amaravati, Krishnanada Pandey, Dinkar, Himkar, Madhukar, Puskar, Prabhakar, Divakar, Subhakar, Ratnakar, Anjali, Salilesh, Abhinav, Anshu, Ramalal, Ramabachan, Ramanaresh, Ramapati, Ramadas, Ramachandra, Ramasakal, Ramadas, Baburam, Prabhu Narayan, Lallan, Ganesh, Indradev, Thamilmani, Gowtham
Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Dr. Ravi S. Pandey at the address: <firstname.lastname@example.org>