Special Issue Call for Papers

American Journal of Biomedical Research

Special Issue Call for Papers

Special Issue on Vaccines and delivery system

Vaccines are the most successful discoveries of biomedical sciences. Due to the lack of enough funding available to vaccine research and the lack of knowledge regarding how do they work in the cellular and molecular level, we do not have successful vaccines against major killer of the human population. These major killers are HIV, malaria, and TB. So, understanding the mechanisms of action of vaccines and vaccine adjuvants on the cellular and molecular level would allow us designing new vaccines against these major killers. Collecting the global literatures, manuscript, understandings and lab results will be contributing factors in enhancing vaccine science.

About the issue

The topics of this special issue include, but are not limited to:

  • Human and animal vaccines-communicable/non-communicable diseases
  • Veterinary vaccines
  • Immunology of vaccines
  • Adjuvants and drug delivery system
  • Animal model in vaccine research

Important dates

Submission Deadline: December 29, 2014
Notification of Acceptance: March 30, 2015
Final Version Due: April 30, 2015
Special Issue Publishing Date: May 30, 2015

Chief Guest Editor

Dr. Tirth Ghimire
Division of Veterinary Health, Global Primate Network, Nepal.
Email: tirtha@primatelife.org

Submit your article now

Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Dr. Tirth Ghimire at the address: <tirtha@primatelife.org>

Special Issue on The Molecular Mechanisms of Regulatory T Cell Immunosuppression

There is an emerging consensus that elevated levels of intracellular cyclic adenosine monophosphate (cAMP) in naturally occurring regulatory T (nTreg) cells may play a key role in nTreg-cell-mediated suppression. During suppression nTreg cells unable to flux Ca2+ upon T cell receptor (TCR) engagement harbor high ‘supraphysiological’ levels of intracellular cAMP by direct binding of Foxp3 to the phosphodiesterase 3b (Pde3b) gene along with downregulation of miR-142-3p, which silences adenylyl cyclase (ADCY9) mRNA also leading to upregulated cAMP production in nTreg cells. Upon contact elevated cAMP levels in nTreg cells are transferred to activated conventional CD4+ T cells (Tcons) via cell contact dependent gap junction intercellular communications (GJIC). Various cell types including T cells may have GJIC formed by Cx43/ZO-1/Ezrin/Protein kinase A (PKA) supramolecular complex where ezrin targeted PKA by phosphorylation of Cx43 controls its opening and closing. However, cAMP increase in inducible Tregs (iTregs) or Tcons could be also receptor-mediated and is operated by various agonists such as prostaglandin E2 (PGE2), adenosine, histamine, serotonine, or adrenergic stimulation, and/or using agonists recognizing CD39/CD73 receptors. Furthermore, phosphodiesterases (PDEs) such as PDE3b can modulate cAMP both on the nTreg as well as Tcon side by exploiting proximal PKA-Csk pathway. Thus, cAMP-dependent signaling can trigger multifaceted molecular mechanisms acting directly as well as indirectly on transcriptional attenuation of interleukin – 2 (IL-2) synthesis in T cons. These events affect interplay of cAMP and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER) and its suppression of nuclear factor of activated T cell (NFAT)-mediated synthesis of IL-2. In addition to its suppressive effects mediated via ICER, cAMP can also modulate the levels of surface-expressed cytotoxic T lymphocyte antigen-4 (CTLA-4) and its cognate B7 ligands on Tcons and/or antigen presenting cells (APCs), fine-tuning suppression. Thus, this Research Topic is focused on articles that can shed some new light on the cAMP-mediated mechanisms responsible for nTreg-mediated immunosuppression of IL-2 synthesis.

About the issue

The scope of topics covered in the this issue include:

  • CD4+ T cells
  • Regulatory T (Treg) cells
  • Gene regulation
  • Costimulatory Molecules
  • Signal transduction

Important dates

Submission Deadline: September, 2014
Notification of Acceptance: October, 2014
Final Version Due: November, 2014
Special Issue Publishing Date: December, 2014

Chief Guest Editor

Josef Bodor
Institute of Experimental Medicine, Academy of Sciences of Czech Republic, EU Centre of Excellence
Email: josef.bodor@biomed.cas.cz

Submit your article now

Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Josef Bodor at the address: <josef.bodor@biomed.cas.cz>

Special Issue on Eradication of Mental Diseases

Human body is genetically controlled and environmentally regulated. The aim of the special issue is to eradicate the diseases of mind with help of Spirit, Devotion, Yoga & Science. Basically, the traits of a human body are depending upon expression profile of genes, which is modulated by the environment in which people alive. Manipulation in genetic pool is a partially promising tool to some limit, but in the current scenario of world environment, where utmost people are living under Lust, Anger, Greed, Pride, Jealous and Infatuation causing a lot of stress, which is the root cause of potential disorder of mind. Anger, those are current picture of maximum woe is beyond the limit of materialistic science. All together, these traits are causing innumerable metal disorders and ultimately reduce human age. Infatuation is the root cause of all ailments and from these again arise many other neurological disorders. Lust is a counterpart of wind and inordinate greed corresponds to an abundance of phlegm, which forms the solid substratum of the body, including immune strength; while anger represents bile, which is responsible for the entire digestive and metabolic functions; which constantly burns the breast. The combination of three (infatuation, lust and greed) causing number of neurodegenerative disorders even suicidal attempts etc. There are many more fell diseases, too numerous to mention. The founder science Vedas and religious scriptures described several path to reduce the above said invincible cause of dangerous ailments. In this special issue, I specially along with other colleagues interested to publish the research work from around the globe for public to reduce the invincible cause of diseases of mind. This approach will definitely lead to enhance aging and reduce the demonic/terrorist activity and ultimately the world will move towards peace.

About the issue

The scope of topics covered in the this issue include:

  • Spirit
  • Devotion
  • Spiritual wisdom
  • Gnosis
  • Modern Yoga
  • Mental disorder
  • Metempsychosis

Important dates

Submission Deadline: September 15, 2014
Notification of Acceptance: November 15, 2014
Final Version Due: November 30, 2014
Special Issue Publishing Date: December 31, 2014

Chief Guest Editor

Dr. Ravi S Pandey
Satya Dham RAMA World center of Truth & Peace
Email: dr.rspandey@yahoo.com

Guest Editor

Sanjib Kumar
Satya Dham RAMA World center of Truth & Peace
Email: Sanjibkumar08@gmail.com

Birendra Singh Rajput
Satya Dham RAMA World center of Truth & Peace
Email: birendra.trcc@gmail.com

Submit your article now

Manuscripts should be submitted as an attached file to an e-mail directed to the Chief Guest Editor, Dr. Ravi S Pandey at the address: <dr.rspandey@yahoo.com>