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American Journal of Medical and Biological Research

ISSN (Print): 2328-4080

ISSN (Online): 2328-4099

Website: http://www.sciepub.com/journal/AJMBR

Current Issue» Volume 2, Number 6 (2014)

Article

Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

1College of Pharmacy, GC University, Faisalabad, Pakistan

2Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan

3Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan


American Journal of Medical and Biological Research. 2014, 2(6), 124-127
DOI: 10.12691/ajmbr-2-6-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Faiza Naseer, Sohail Ahmad, Attiya Nazish, Fiza Raza Bukhari, Atta Ur Rehman, Imran Mahmood Khan, Samra Sadiq, Fatima Javed. Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice. American Journal of Medical and Biological Research. 2014; 2(6):124-127. doi: 10.12691/ajmbr-2-6-2.

Correspondence to: Faiza  Naseer, College of Pharmacy, GC University, Faisalabad, Pakistan. Email: faiza.naseer@ymail.com

Abstract

The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.

Keywords

References

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Article

Pre Eclampsia and Iron Status: A Review

1Department of Biochemistry, Chalmeda AnandRao Institute of Medical Sciences, Bommakal, Karimnagar, Andhra Pradesh

2Department of Obsterics and Gynaecology, Chalmeda AnandRao Institute of Medical Sciences, Bommakal, Karimnagar, Andhra Pradesh

3Department of Microbiology, Prathima institute of Medical Sciences, Nagnur, Karimnagar, Andhra Pradesh


American Journal of Medical and Biological Research. 2014, 2(6), 121-123
DOI: 10.12691/ajmbr-2-6-1
Copyright © 2014 Science and Education Publishing

Cite this paper:
Sabitha Kandi, Sudhakar T, C Ramadevi, B Venugopal, Rajkumar, Md Rafi, K V Ramana. Pre Eclampsia and Iron Status: A Review. American Journal of Medical and Biological Research. 2014; 2(6):121-123. doi: 10.12691/ajmbr-2-6-1.

Correspondence to: K  V Ramana, Department of Microbiology, Prathima institute of Medical Sciences, Nagnur, Karimnagar, Andhra Pradesh. Email: tejaswani19@gmail.com

Abstract

Preeclampsia is an idiopathic multisystem disorder specific to pregnancy and development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother , altered placental perfusion and restricted fetal growth. The vasospasm leads to destruction of RBCs release iron thus, there is elevated serum iron levels in preeclamptic women. The excess iron released from destruction of RBCs can react with free radicals produced from cell membrane (as it is rich in polyunsaturated fatty acids) and circulating lipoproteins initiates lipid peroxidation both in placenta and vasculature. This is one of the significant etiologic factors in the endothelial cell damage of preeclampsia. the raised serum iron levels in turn alters the iron related parameters like total iron binding capacity(TIBC), serum ferritin, transferrin, percent saturation.

Keywords

References

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