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American Journal of Cancer Prevention

ISSN (Print): 2328-7322

ISSN (Online): 2328-7314

Editor-in-Chief: Nabil Abdel-Hamid

Website: http://www.sciepub.com/journal/AJCP

   

Article

Apple Cider Vinegar (A Prophetic Medicine Remedy) Protects against Nicotine Hepatotoxicity: A Histopathological and Biochemical Report

1Department of Anatomy, Faculty of Clinical Pharmacy, Taif University, KSA

2Department of Anatomy, Faculty of Medicine, Sohag University, Egypt

3Department of Pathology, Al-Ghad International Medical Sciences Colleges, Al-Madinah, KSA

4Department of Pathology, Faculty of Medicine, Sohag University, Egypt

5Department of Animal Production, Faculty of Agriculture, Jordan University, Jordan

6Department of Medical Biochemistry, Tanta Faculty of Medicine, Tanta University, Egypt

7Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

8Department of Clinical Pathology, Faculty of Medicine, 6th October University, Cairo, Egypt

9Ph.D of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt

100Department of Internal Medicine, Tanta Faculty of Medicine, Tanta University, Egypt

111Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt


American Journal of Cancer Prevention. 2015, 3(6), 122-127
doi: 10.12691/ajcp-3-6-4
Copyright © 2016 Science and Education Publishing

Cite this paper:
Nassar Ayoub Abdellatif Omar, Amal Nor Edeen Ahmad Allithy, Firas Mahmoud Faleh, Reham A. Mariah, Mongi Mohamed Ahmed Ayat, Sherine Ragab Shafik, Samah A. Elshweikh, Salah Mohamed El Sayed. Apple Cider Vinegar (A Prophetic Medicine Remedy) Protects against Nicotine Hepatotoxicity: A Histopathological and Biochemical Report. American Journal of Cancer Prevention. 2015; 3(6):122-127. doi: 10.12691/ajcp-3-6-4.

Correspondence to: Salah  Mohamed El Sayed, Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia. Email: salahfazara@yahoo.com, drsalahpediatr@yahoo.com

Abstract

Nicotine is the most abundant component in cigarette smoking and is involved in the pathogenesis of lung cancer and increases the risk of developing hepatocellular carcinoma and liver cirrhosis. Prevention of nicotine-induced lung cancer and liver damage may be achieved via decreasing nicotine-induced pathological effects. Nicotine is metabolized in the liver. Natural diet contains a variety of compounds e.g. apple cider vinegar (ACV) that exhibits protective effects against different toxins. This study aims to investigate the effects of nicotine on the liver using morphometrical, histopathological and biochemical parameters and study the protective effect of ACV against toxicity of nicotine. Three groups of the male albino rat were used: untreated control group, nicotine treated group (4 mg/kg/day) while the third group received both ACV (2ml/kg/day) and nicotine (4 mg/kg/day). Treatment was given for 30 days. There was a significant increase in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) together with a damage and degeneration in the liver tissues of the nicotine treated groups. ACV administration to nicotine-treated rats showed near normal liver biochemical markers with reduction in the tissue damage associated with the nicotine administration. ACV administration to nicotine-treated rat ameliorated the decrease in the size of the hepatocytes nuclei. These results, along with previous observations, suggest that ACV may be useful in combating tissue injury resulting from nicotine toxicity. In prophetic medicine, Prophet Muhammad peace be upon him strongly recommended eating vinegar in the prophetic hadeeth: "vinegar is the best edible". Conclusion: These finding confirm that chronic nicotine administration causes harmful effects to the liver and suggest that ACV may be useful in combating tissue injury resulting from nicotine toxicity. Hence, the intake of ACV might suppress the toxicity and mutagenic activity of nicotine. ACV may protect against nicotine-induced carcinogenesis.

Keywords

References

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Article

Graviola: A Systematic Review on Its Anticancer Properties

1School of Medicine, European University Cyprus, Nicosia, Cyprus


American Journal of Cancer Prevention. 2015, 3(6), 128-131
doi: 10.12691/ajcp-3-6-5
Copyright © 2016 Science and Education Publishing

Cite this paper:
Patrikios Ioannis, Stephanou Anastasis, Yiallouris Andreas. Graviola: A Systematic Review on Its Anticancer Properties. American Journal of Cancer Prevention. 2015; 3(6):128-131. doi: 10.12691/ajcp-3-6-5.

Correspondence to: Patrikios  Ioannis, School of Medicine, European University Cyprus, Nicosia, Cyprus. Email: i.patrikios@euc.ac.cy

Abstract

There has been an enormous interest in the literature that phyto-compounds have therapeutic and beneficial effects in various diseases including inflammatory associated arthritis, diabetes, hypertension, parasitic infections, and cancer. The leaves from the tropical tree Annona Muricata, also known as Graviola have been reported to have positive and effective properties against many of the above mentioned diseases. Cancer still remains the number one killer in the Western nations and most treatments for the disease rely on the use of chemotherapy that utilizes drugs that are also toxic against normal healthy cells. Thus, an alternative approach to anti-cancer therapies should involve the determination of novel drug targets that must be highly effective and specific against cancer development and growth. Additionally, the new generation novel drugs should be non-toxic to the host cells and affordable for the patients. This review summarizes the recent findings on the effects of Graviola tree extract as a novel anti-cancer agent for the treatment and prevention of cancers; a possible natural anti-cancer candidate agent in line with all the attributes pointed above.

Keywords

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Article

Meeting or Exceeding Physical Activity Guidelines is Associated with Reduced Risk for Cancer in Mexican-Americans

1Department of Epidemiology & Biostatistics, University of Texas Health Science Center at San Antonio-Laredo Campus, Laredo, TX (SW)

2Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, TX (SPF, JBM)

3Division of Health Promotion and Health Behavior University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, TX


American Journal of Cancer Prevention. 2016, 4(1), 1-7
doi: 10.12691/ajcp-4-1-1
Copyright © 2016 Science and Education Publishing

Cite this paper:
Shenghui Wu, Susan P. Fisher-Hoch, Belinda Reninger, Joseph B. McCormick. Meeting or Exceeding Physical Activity Guidelines is Associated with Reduced Risk for Cancer in Mexican-Americans. American Journal of Cancer Prevention. 2016; 4(1):1-7. doi: 10.12691/ajcp-4-1-1.

Correspondence to: Joseph  B. McCormick, Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, TX (SPF, JBM). Email: Joseph.b.mccormick@uth.tmc.edu

Abstract

Background: Epidemiologic studies have shown that inadequate physical activity was associated with cancers in whites and other ethnic groups, but in Mexican-Americans data are limited. This study aimed to measure the association between physical activity and reported cancer risk in Mexican-Americans. Methods: Participants were drawn from the Cameron County Hispanic Cohort (n=3,391), a randomly selected Mexican-American cohort in Texas on the US-Mexico border. Physical activity was assessed using the International Physical Activity Questionnaire. Cancer was self-reported by the participants as being told by a health care provider that they had cancer. Results: Ninety-nine participants of the cohort (2.94%) reported a diagnosis of cancer. Compared to participants who did not meet US physical activity guidelines, subjects who met physical activity guidelines of 150 moderate and vigorous minutes per week (≥ 600 METs) reduced their risk for cancer by 87% (OR=0.13; 95% CI: 0.03-0.54), and subjects with total minutes per week of moderate and vigorous/strenuous activity greater than 745 METs decreased cancer risk by 86% [odds ratio (OR)=0.14; 95% confidence interval (CI): 0.03-0.60] comparing with their counterparts, after adjusting for age, gender, body mass index, smoking and alcohol drinking status, education and total portions of fruit and vegetable intake. Conclusions: Meeting or exceeding recommended levels of moderate and vigorous physical activity was associated with a significantly reduced risk of reporting cancer by Mexican-Americans. Meeting or exceeding recommended levels of physical activity appears to be an effective target for cancer prevention and control among Mexican-Americans independent of BMI and other factors.

Keywords

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