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American Journal of Cardiovascular Disease Research

ISSN (Print): ISSN Pending

ISSN (Online): ISSN Pending

Editor-in-Chief: Dario Galante




The Metabolic Syndrome in Offspring of Women with a Family History of Early Onset Type 2 Diabetes Mellitus Who Developed Gestational Diabetes Mellitus

1Department of Basic Medical Sciences, Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica

American Journal of Cardiovascular Disease Research. 2016, 4(1), 1-6
doi: 10.12691/ajcdr-4-1-1
Copyright © 2016 Science and Education Publishing

Cite this paper:
R Irving. The Metabolic Syndrome in Offspring of Women with a Family History of Early Onset Type 2 Diabetes Mellitus Who Developed Gestational Diabetes Mellitus. American Journal of Cardiovascular Disease Research. 2016; 4(1):1-6. doi: 10.12691/ajcdr-4-1-1.

Correspondence to: R  Irving, Department of Basic Medical Sciences, Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica. Email:


Objective: To evaluate for the metabolic syndrome (MS) in offspring of women with family history of early onset type 2 diabetes mellitus (T2DM) who developed gestational diabetes mellitus (GDM) using as controls offspring of women with no family history of diabetes and normal glucose tolerance (NGT). Methods: Anthropometric and biochemical measurements were evaluated for 30 offspring age 10-16 years of women with family history of early onset T2DM who developed GDM. Obstetrical records of these mothers were also noted. Thirty offspring of women (30) with NGT and no family history of diabetes served as controls. Measurements included: Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting and postprandial glucose, insulin, waist circumference, weight and height. For analyses, MS was defined as ≥3 of 4 features: glucose intolerance, dyslipidemia, obesity and hypertension in the childhood/adolescence criteria as recommended by the National Cholesterol Education Program Adult Treatment Panel Third (NCEP-ATP III) modified standard. Cox regression analysis was used to determine the independent hazard (risk) of developing MS attributable to GDM with a family history of early onset T2DM. Results: Offspring of women with GDM and family history of early onset T2DM had significantly more (≥ 2, p<0.05) features of MS than offspring of women with NGT and no family history of diabetes. Thirty percent (30.0%), 29.5% and 39.0% of the offspring of these GDM women had glucose intolerance, obesity and dyslipidemia respectively. These offspring had a hazard of 3.33 (95% CI: 2.12-9.15) of having MS compared to offspring of women with NGT and no family history of diabetes. Conclusion: Offspring of women with GDM and family history of early onset T2DM are at increased risk for MS.



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Severe Cardiomyopathy from Limb Girdle Muscular Dystrophy: A Nidus for a Catastrophic Cascade

1Department of Medicine, Overlook Medical Center, Summit, NJ, USA

2Department of Cardiology, Morristown Medical Center, Morristown, NJ, USA

American Journal of Cardiovascular Disease Research. 2016, 4(1), 7-10
doi: 10.12691/ajcdr-4-1-2
Copyright © 2016 Science and Education Publishing

Cite this paper:
Glenmore Lasam, Jenny Lam. Severe Cardiomyopathy from Limb Girdle Muscular Dystrophy: A Nidus for a Catastrophic Cascade. American Journal of Cardiovascular Disease Research. 2016; 4(1):7-10. doi: 10.12691/ajcdr-4-1-2.

Correspondence to: Glenmore  Lasam, Department of Medicine, Overlook Medical Center, Summit, NJ, USA. Email:


We report a case of a 57-year-old female with Limb Girdle Muscular Dystrophy (LGMD) who initially presented to her outpatient physician a year ago with progressive shoulder and pelvic girdle muscle weakness associated with slight limitation of movement, gradual onset of easy fatigability, intermittent episodes of exertional dyspnea, and trace bipedal edema. On the day of admission, she had sudden onset of unresponsiveness due to massive cerebral infarct likely cardioembolic as evidenced by left ventricular thrombus, in the setting of severe cardiomyopathy associated from LGMD. The patient was treated with hemodynamic support and systemic anticoagulation but did not show any signs of neurologic improvement. Comfort care measures were initiated, eventually, the patient succumbed to death.



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Aortic Dissection Presenting with New Onset Slow Atrial Fibrillation

1Department of Internal Medicine, Faculty of Medical Sciences, University of Duhok, Kurdistan, Iraq

2Fellow in Internal Medicine, Duhok directorate of Health, Kurdistan, Iraq

American Journal of Cardiovascular Disease Research. 2016, 4(1), 11-14
doi: 10.12691/ajcdr-4-1-3
Copyright © 2016 Science and Education Publishing

Cite this paper:
Ameen Mosa Mohammad, Shivan Umir Mohammed. Aortic Dissection Presenting with New Onset Slow Atrial Fibrillation. American Journal of Cardiovascular Disease Research. 2016; 4(1):11-14. doi: 10.12691/ajcdr-4-1-3.

Correspondence to: Ameen  Mosa Mohammad, Department of Internal Medicine, Faculty of Medical Sciences, University of Duhok, Kurdistan, Iraq. Email:


Here we present a case of 45 year old male who presented to the emergency department in Duhok, Kurdistan, Iraq in 2014 suffering of two hours sudden onset of dizziness and repeated vomiting. He had unremarkable past medical and drug histories apart of current smoking. On examination the patient was conscious, Pulse rate is 50 bpm and irregular, BP is 90/60 mmHg, evidence of audible murmur on heart auscultation, ECG showed slow atrial fibrillation, Cardiac enzymes were negative. Transthoracic echo (TTE) showed severe aortic regurgitation with a dissecting intimal flap in the ascending aorta. Chest CT-scan was ordered to confirm the dissection and then the patient underwent successful aortic dissection repair. A link between slow atrial fibrillation and aortic dissection has not previously recognized.



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