World Journal of Organic Chemistry
ISSN (Print): 2372-2150 ISSN (Online): 2372-2169 Website: http://www.sciepub.com/journal/wjoc Editor-in-chief: Subrata Shaw
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World Journal of Organic Chemistry. 2021, 9(1), 18-28
DOI: 10.12691/wjoc-9-1-3
Open AccessArticle

Carboxymethylcellulose-supported Palladium Nanoparticles Formed in situ for Suzuki-Miyaura Coupling Reaction

Xiaojian Liao1, Yuemin Zhou1, Fu Tang1, Xia Lin1 and Yiqun Li1,

1Department of Chemistry, College of Chemistry and Materials Science, Panyu Campus, Jinan University, Guangzhou, 511443, China

Pub. Date: September 09, 2021

Cite this paper:
Xiaojian Liao, Yuemin Zhou, Fu Tang, Xia Lin and Yiqun Li. Carboxymethylcellulose-supported Palladium Nanoparticles Formed in situ for Suzuki-Miyaura Coupling Reaction. World Journal of Organic Chemistry. 2021; 9(1):18-28. doi: 10.12691/wjoc-9-1-3

Abstract

A green experiment is described here for direct fabrication of carboxymethylcellulose-supported palladium nanoparticles (PdNPs@CMC) in situ through a simple self-assemble and self-reduction process between carboxymethylcellulose (CMC-Na) and PdCl2 solution. The PdNPs@CMC was well characterized by ICP, UV-Vis, XPS, FTIR, SEM, and TEM techniques. The in situ synthesized PdNPs@CMC was proved to be an efficient catalyst for Suzuki-Miyaura coupling reaction under mild aerobic conditions. The superior catalytic performance of PdNPs@CMC is attributed to the coordination with carboxyl groups (−COO) and free hydroxyl groups (−OH) as well as polymeric capping effect of CMC. Moreover, the catalyst showed no significant loss of its activity at least three consecutive cycles. This laboratory class is involved in the preparation and characterization of PdNPs@CMC as well as its catalytic application in Suzuki−Miyaura cross coupling reaction under green conditions. This laboratory class is suggested to divide into two parts. The first part includes the fabrication of catalyst in situ through a self-assemble and self-reduction of Pd(II) with CMC−Na, and characterization of the as-prepared catalyst using various techniques. The second part employs the resulting catalyst to perform a microscale Suzuki-Miyaura reaction, recycling of catalyst, and characterization of the product. By design, this comprehensive experiment set up for the third-year undergraduate, and aim to make students comprehend the concept of ion-exchange reaction, reduction reaction, carbon-carbon coupling reaction, supported catalysts, nanoparticles, and green chemistry as well as train the fundamental operation capability of students, and improve their experimental skills.

Keywords:
organic experiment green chemistry Suzuki-Miyaura reaction supported catalyst palladium nanoparticles carboxymethylcellulose upper-division undergraduate hands-on learning/manipulatives

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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