World Journal of Organic Chemistry
ISSN (Print): 2372-2150 ISSN (Online): 2372-2169 Website: Editor-in-chief: Subrata Shaw
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World Journal of Organic Chemistry. 2019, 7(1), 1-4
DOI: 10.12691/wjoc-7-1-1
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On the Mechanism of the Froehde Reaction

Francisco Sánchez-Viesca1, and Reina Gómez1

1Organic Chemistry Department, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City (CDMX), Mexico

Pub. Date: January 16, 2019

Cite this paper:
Francisco Sánchez-Viesca and Reina Gómez. On the Mechanism of the Froehde Reaction. World Journal of Organic Chemistry. 2019; 7(1):1-4. doi: 10.12691/wjoc-7-1-1


Although the Froehde reaction is widely used for alkaloid preliminary identification, there is no reaction mechanism in order to explain the reaction course and the end products. We found there can be two redox steps and we provide a reaction mechanism for both of them and give two routes for the second reaction. The chemical deportment of the reagent, molybdic acid and its derivatives is also discussed.

alkaloids aromatic hydroxylation molybdene dioxide molybdic acid reactive intermediates redox reactions

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