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Various Analytical Methodologies for Determination of Selective α1A Receptor Blocker Tamsulosin Hydrochloride and Its Combinations in Different Matrices

1Department of Pharmaceutical Analysis. Tifac-core Innovation square, B.R. Nahata College of Pharmacy, Mandsaur, India


World Journal of Analytical Chemistry. 2013, 1(3), 37-48
DOI: 10.12691/wjac-1-3-3
Copyright © 2013 Science and Education Publishing

Cite this paper:
Alankar Shrivastava, Pratibha Aggrawal. Various Analytical Methodologies for Determination of Selective α1A Receptor Blocker Tamsulosin Hydrochloride and Its Combinations in Different Matrices. World Journal of Analytical Chemistry. 2013; 1(3):37-48. doi: 10.12691/wjac-1-3-3.

Correspondence to: Alankar Shrivastava, Department of Pharmaceutical Analysis. Tifac-core Innovation square, B.R. Nahata College of Pharmacy, Mandsaur, India. Email: alankar@brncop.com

Abstract

Tamsulosin is a more selective α1A subtype antagonist, which maintains the α-antagonist effect on the prostatic capsule and bladder neck but has less of an effect on the vascular system and blood pressure. It has a better side effect profile than earlier α-adrenergic-receptor antagonists, which were initially developed as antihypertensive agents. Tamsulosin hydrochloride is clinically important drug as far as benign prostatic hyperplasia is concerned. Thus in this review all of the analytical methods reported in the literature are summarized. Different spectrophotometric, chromatographic, electroanalytical and some other types of analytical methods were discussed here. Analytical methods were compared in terms of sensitivity, range, applications and economy. The presented review is helpful for the researchers involved in the development of new analytical methods or formulations of Tamsulosin hydrochloride.

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References

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Article

Stability Indicating HPTLC Determination of Terazosin in Tablet Formulation

1Department of Pharmaceutical Analysis, B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India

2B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India


World Journal of Analytical Chemistry. 2013, 1(3), 31-36
DOI: 10.12691/wjac-1-3-2
Copyright © 2013 Science and Education Publishing

Cite this paper:
Alankar SHRIVASTAVA, Abhishek PATEL, Vipin B. GUPTA. Stability Indicating HPTLC Determination of Terazosin in Tablet Formulation. World Journal of Analytical Chemistry. 2013; 1(3):31-36. doi: 10.12691/wjac-1-3-2.

Correspondence to: Alankar SHRIVASTAVA, Department of Pharmaceutical Analysis, B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India. Email: alankar@brncop.com

Abstract

A simple, rapid and precise HPTLC method was developed for the quantitative estimation of terazosin hydrochloride in pharmaceutical dosage form. Good sharp peak was obtained in mobile phase composition Chloroform:Toluene:MeOH (9:1:6) at Rf ≈ 8. Stationary phase was silica gel precoated aluminum plate 60F-254 plates, [20cm × 10cm with 250μm thickness and wavelength selected was 254nm. Terazosin was exposed to acidic, alkaline, thermal, photolytic and oxidative stress conditions, and the stressed samples were analyzed by the proposed method. The described method showed linearity over a range of 50-2500μg/ml. The correlation coefficient is 0.999. Overall, the proposed method was found to be suitable and accurate for quantitative determination and stability study of terazosin in pharmaceutical dosage form.

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Article

Dissipation and Residues of Penconazole in Grape Fruits

1Central Agricultural Pesticide Laboratory, Pesticide Residues and Environmental Pollution Department, Agriculture Research center, Dokki, Giza, Egypt

2Department of Chemistry, Faculty of Sciences, Benha University, Benha, Egypt


World Journal of Analytical Chemistry. 2013, 1(3), 28-30
DOI: 10.12691/wjac-1-3-1
Copyright © 2013 Science and Education Publishing

Cite this paper:
Ehab Hassan, Nevien Ahmed, Mohamed Arief. Dissipation and Residues of Penconazole in Grape Fruits. World Journal of Analytical Chemistry. 2013; 1(3):28-30. doi: 10.12691/wjac-1-3-1.

Correspondence to: Ehab Hassan, Central Agricultural Pesticide Laboratory, Pesticide Residues and Environmental Pollution Department, Agriculture Research center, Dokki, Giza, Egypt. Email: ehabhassan3006@yahoo.com

Abstract

The main objective of this study was to understand the residue and persistence behavior of Penconazole fungicide in grape fruit samples. The residues were analyzed by GC. The average initial deposit of in grape fruit was observed to be 1.04 mg kg-1 at single application rate. The recoveries of Penconazole on grape fruit were observed from 91.04% to 92.13% at fortification levels of 0.1, 0.5 and 1.0 mg kg-1. The reported limit of quantification (LOQ) was found to be 0.02 mg kg-1. The dissipation experiments showed the half-lives (T1/2) of Penconazole were around 1.56 days. According to the maximum residue limit (MRL) the pre-harvest interval (PHI) of Penconazole on grape was 14 days after the treatment.

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