World Journal of Analytical Chemistry
ISSN (Print): 2333-1178 ISSN (Online): 2333-1283 Website: http://www.sciepub.com/journal/wjac Editor-in-chief: Raluca-Ioana Stefan-van Staden
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World Journal of Analytical Chemistry. 2015, 3(1A), 6-8
DOI: 10.12691/wjac-3-1A-2
Open AccessResearch Article

Effect of Vitamin C on Blood Glucose and Glycosylated Hemoglobin in Type II Diabetes Mellitus

Ashraf kotb1, and Khaldun M. Al Azzam2

1Department of Physiology, Medicine program, Batterjee Medical College for Sciences and Technology (BMC), 21442 Jeddah, Kingdom of Saudi Arabia

2Department of Pharmaceutical Chemistry, Pharmacy Program, Batterjee Medical College for Sciences and Technology (BMC), 21442 Jeddah, Kingdom of Saudi Arabia

Pub. Date: September 06, 2015
(This article belongs to the Special Issue Recent Development of Pharmaceutical and Biomedical Analysis)

Cite this paper:
Ashraf kotb and Khaldun M. Al Azzam. Effect of Vitamin C on Blood Glucose and Glycosylated Hemoglobin in Type II Diabetes Mellitus. World Journal of Analytical Chemistry. 2015; 3(1A):6-8. doi: 10.12691/wjac-3-1A-2

Abstract

Ascorbic acid (vitamin C) is an antioxidant which is hypothesized to have an effect on the blood glucose in patients with type II diabetes. The aim of the study is to examine the effect of oral vitamin C on fasting blood glucose (FBG), two hours postprandial blood glucose (PPBG) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). One hundred patients participated in this study were divided into two groups. The first group was the control group contained fifty normal patients. The second group contained fifty patients having type II DM and given the drug Glucophage at a dose of 2000 mg/day beside healthy diet to control diabetes. They were left for three months then the blood samples were collected from both groups to detect the FBG, two hours PPBG and HbA1c. After that, the diabetic group was given beside the drug and diet treatment vitamin C drug (Vitacid calcium) 1000 mg orally three times /day for another three months. At the end of the three months, blood samples were collected from both groups to examine the FBG, two hours PPBG and the HbA1c. The diabetic group recorded a significantly higher level of FBG, two hours PPBG and HbA1c compared to the control group after the first three months. The diabetic group after being given vitamin C beside the drug and diet for three months recorded a significant decreased level of FBG, two hours PPBG, and HbA1c compared to the levels it recorded before without being given the vitamin C. In conclusion, oral supplementation of vitamin C reduces FBG, two hours PPBG, and improves HbA1c. Hence, its combination with diabetic drugs may be beneficial in the treatment of type II DM to maintain good glycemic control.

Keywords:
vitamin C blood glucose Vitacid calcium diabetes mellitus glycemic control

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References:

[1]  Mesallamy, H. E., Suwailem, S., and Hamdy N. Evaluation of C-reactive protein, endothelin-1, adhesion molecule (s), and lipids as inflammatory markers in type 2 diabetes mellitus patients. Mediators of Inflammation, 2007: 1-7. 2007.
 
[2]  Bianchi, C., Miccoli, R., Daniele, G., Penno, G., and Del Prato S., “Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes. Diabetes Care, 32: S337-S341. 2009.
 
[3]  Fadupin, G.T., Akpoghor, A. U., and Okunade, K. A. A comparative study of serum ascorbic acid level in people with and without type 2 diabetes in Ibadan, Nigeria. African Journal of Medicine and Medical Sciences, 36: 335-339. 2007.
 
[4]  Ardekani, M. A., and Ardekani, A. S. Effect of vitamin C on blood glucose, serum lipids & serum insulin in type II diabetes patients. Indian Journal of Medical Research, 126: 471-474. 2007.
 
[5]  Sargeant, L. A., Wareham, N. J., Bingham, S., Day, N. E., Luben, R. N., Oakes, S., Welch, A., and Khaw, K. T. Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer--Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care. 23: 726-732. 2000.
 
[6]  Davies, M. B., Austin, J. A., Partridge, D.A. Vitamin C: Its Chemistry and Biochemistry. The Royal Society of Chemistry, 1991. p. 48.
 
[7]  Heitzer,T., schling, T., Krohn, K.. Oxidative stress and risk of cardiovascular events in patients with coronary disease. Circulation. 104: 2673-2678. 2001.
 
[8]  Sridulyakul, P., Chakraphan, D., Patumraj, S. Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats. Clinical Hemorheology and Microcirculation. 34: 315-321. 2006.
 
[9]  Ardekani, M. A., Mohiti, J., Amirchaghmaghi, E., and Modarresi, M. The effect of vitamin C supplementation on insulin level, HbA1c and blood glucose in type 2 diabetic patients. Journal of Kerman University of Medical Sciences. 11: 12-18. 2006.
 
[10]  Bonnefont-Rousselot, D., Bastard, J. P., Jaudon, M. C., and Delattre, J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes and Metabolism. 26: 163-176. 2000.
 
[11]  Vincent, T. E., Mendiratta, S., May, J. M. Inhibition of aldose reductase in human erythrocytes by vitamin C. Diabetes Research and Clinical Practice. 43: 1-8. 1999.
 
[12]  Srivatsan, R., Das, S., Gadde, R., Manoj-Kumar, K., Taduri, S., Rao, N., Ramesh, B., Baharani, A., Shah, K., Kamireddy, S. C., Priyatham, G., Balakumaran, T. A., Balakumaran, S. S., Kamath, and A., Rao, A. Antioxidants and lipid peroxidation status in diabetic patients with and without complications. Archives of Iranian Medicine. 12: 121-127. 2009.
 
[13]  Craven, P. A., DeRubertis, F. R., Kagan, V. E., Melhem, M., and Studer, R. K. Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-β, and glomerular size in diabetes. Journal of the American Society of Nephrology. 89: 1405-1414. 1997.
 
[14]  Sridulyakul, P., Chakraphan, D., Patumraj, S. Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats. Clinical Hemorheology and Microcirculation. 34: 315-321. 2006.
 
[15]  Szaleczky, E., ózsef Prechl, J., Ruzicska, E., Feher, J., Braun, L., Banhegyi, G., Csala, M., Mandl, J., and Somogyi, A. Reduction of glycated hemoglobin levels by long term, high dose ascorbic acid supplementation in healthy and diabetic patients. Medical Science Monitor. 4: 241-244. 1998.
 
[16]  Montonen, J., Knekt, P., Järvinen, R., Reunanen, A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care. 27: 362-366. 2004.
 
[17]  Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A. C., Dauchet, L., Galan, P., Hercberg, S. Antioxidant supplementation does not affect fasting plasma glucose in the supplementation with antioxidant vitamins and minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. American Journal of Clinical Nutrition. 84: 395-399. 2006.