Research in Psychology and Behavioral Sciences
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Research in Psychology and Behavioral Sciences. 2014, 2(1), 6-10
DOI: 10.12691/rpbs-2-1-2
Open AccessArticle

Plus Maze Selection of Anxious and Non-Anxious Rats: A Behavioral and Neurochemical Evaluation

Rogerio Correa Peres1, , Rita Mattei2 and Jose Roberto Leite3

1Departamento de Biociências, Universidade Federal de São Paulo (UNIFESP), Santos-SP, Brazil

2Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP), Santos-SP, Brazil

3Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Santos-SP, Brazil

Pub. Date: February 13, 2014

Cite this paper:
Rogerio Correa Peres, Rita Mattei and Jose Roberto Leite. Plus Maze Selection of Anxious and Non-Anxious Rats: A Behavioral and Neurochemical Evaluation. Research in Psychology and Behavioral Sciences. 2014; 2(1):6-10. doi: 10.12691/rpbs-2-1-2


The development of animal models of anxiety is of great importance to detect potential anxiolytic drugs and study the anxiety phenomenon. The selection of anxious and non anxious rats in animal may represent a good procedure to help study rats behavior when tested in animal models. The present study aimed to investigate the differences among rats selected in an elevated plus maze test. Rats were selected as anxious when they spent time measures 1 sd lower than the average in open arms of the maze and non anxious spent 1 sd higher than the average. The non anxious selected rats showed lower emotional reactivity when tested in open field test and social interaction test as well as decrease of 5HT/5HIAA ratio in frontal cortex when compared with anxious selected rats. The results point to differences among the selected rats what suggest the procedure should be considered in anxiety studies.

anxiety anxious rats genetic selection experimental behavioral tests elevated plus maze serotonin

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