Oral Surgery, Oral Medicine, Oral Radiology
ISSN (Print): 2379-5298 ISSN (Online): 2379-5301 Website: http://www.sciepub.com/journal/oral Editor-in-chief: Bouguezzi Adel
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Oral Surgery, Oral Medicine, Oral Radiology. 2014, 2(2), 14-16
DOI: 10.12691/oral-2-2-2
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Rare Case Reports of Non Syndromic Hypodontia – Genes at Work

Arati Paranjpe1, , Priyanka Sawant1, Avinash Kshar1 and Raghvendra Byakodi1

1Oral Medicine and Radiology, Vasantdada Patil Dental College and Hospital, Sangli, India

Pub. Date: May 21, 2014

Cite this paper:
Arati Paranjpe, Priyanka Sawant, Avinash Kshar and Raghvendra Byakodi. Rare Case Reports of Non Syndromic Hypodontia – Genes at Work. Oral Surgery, Oral Medicine, Oral Radiology. 2014; 2(2):14-16. doi: 10.12691/oral-2-2-2


Agenesis of one or more permanent teeth is a common developmental dental anomaly in human beings. In the literature, many terms are used to describe missing teeth like oligodontia, anodontia, aplasia of teeth, congenitally missing teeth, absence of teeth, agenesis of teeth and lack of teeth. The etiology of missing teeth may be environmental factors like infection, trauma, drugs, chemotherapy or radiotherapy or may be genetic. The most often missing permanent teeth, excluding third molars, are the second premolars and the lateral incisors. Here we report two cases of hypodontia of permanent teeth which are familial and without the presence of any syndrome. We have also reviewed literature of similar cases published till date.

hypodontia familial tooth agenesis

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[1]  Vahid-Dastjerdi E, Borzabadi-Farahani A, Mahdian M, Amini N. Non-syndromic hypodontia in an Iranian orthodontic population. J Oral Sci. 2010; 52 (3): 455-61.
[2]  Shashikiran ND, Karthik V, Subbareddy VV. Multiple congenitally missing primary teeth: report of a case. Pediatr Dent. 2002; 24 (2): 149-52.
[3]  Fukuta Y, Totsuka M, Takeda Y, Yamamoto H. Congenital absence of the permanent canines: a clinico-statistical study. J Oral Sci. 2004; 46 (4): 247-52.
[4]  Peker I, Kaya E, Darendeliler-Yaman S. Clinical and radiographical evaluation of non-syndromic hypodontia and hyperdontia in permanent dentition. Med Oral Patol Oral Cir Bucal. 2009; 14 (8): e393-7.
[5]  Vanishree G, Reddy VS. Oligodontia of permanent teeth- Rare case report. AEDJ. 2010; 2 (4): 101-4.
[6]  Newman GV, Newman RA. Report of four familial cases with congenitally missing mandibular incisors. Am J Orthod Dentofacial Orthop. 1998; 114 (2): 195-207.
[7]  Larmour CJ, Mossey PA, Thind BS, Forgie AH, Stirrups DR. Hypodontia - A retrospective review of prevalence and etiology. Part 1. Quintessence Int 2005; 36 (4): 263-70.
[8]  Bala M, Pathak A. Ectodermal dysplasia with true anodontia. J Oral Maxillofac Pathol. 2011; 15 (2): 244-6.
[9]  Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seidman CE. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet. 1996; 13 (4): 417- 21.
[10]  Stockton DW, Das P, Goldenberg M, D’Souza RN, Patel PI. Mutation of PAX9 is associated with oligodontia. Nat Genet. 2000; 24 (1): 18-9.
[11]  Frazier-Bowers SA, Guo DC, Cavender A, Xue L, Evans B, King T et al. A novel mutation in human PAX9 causes molar oligodontia. J Dent Res. 2002; 81 (2): 129-33.
[12]  Lidral AC, Reising BC. The role of MSX1 in human tooth agenesis. J Dent Res 2002; 81 (4): 274-8.
[13]  Das P, Stockton DW, Bauer C, Shaffer LG, D'Souza RN, Wright T et al. Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia. Hum Genet. 2002; 110 (4): 371-6.
[14]  Ranta R, Hereditary agenesis of ten maxillary posterior teeth: a family history. ASDC J Dent Child. 1985; 52 (2): 125-7.
[15]  Lyngstadaas SP, Nordbo H, Gedde-Dahl T Jr, Thrane PS. On the genetics of hypodontia and microdontia: synergism or allelism of major genes in a family with six affected members. J Med Genet. 1996; 33 (2): 137-42.
[16]  Tao R, Jin B, Guo SZ, Qing W, Feng GY, Brooks DG et al. A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia. J Hum Genet. 2006; 51 (5): 498-502.