Global Journal of Surgery
ISSN (Print): 2379-8742 ISSN (Online): 2379-8750 Website: Editor-in-chief: Baki Topal
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Global Journal of Surgery. 2014, 2(1), 12-15
DOI: 10.12691/js-2-1-4
Open AccessArticle

The Study of Diagnostic Value of Placental Growth Factor for Predicting Pre-eclampsia in the First Trimester of Pregnancy

Sohrabi Nahid1, and Yazdan Mehr Khadije2

1Assistant Professor, Firouzgar Hospital, Faculty of Medicine, Tehran University of Medical Sciences

2Resident, Firouzgar Hospital, Faculty of Medicine, Tehran University of Medical Sciences

Pub. Date: March 16, 2014

Cite this paper:
Sohrabi Nahid and Yazdan Mehr Khadije. The Study of Diagnostic Value of Placental Growth Factor for Predicting Pre-eclampsia in the First Trimester of Pregnancy. Global Journal of Surgery. 2014; 2(1):12-15. doi: 10.12691/js-2-1-4


Background: Preeclampsia is the most common pregnancy problems which are characterized by hypertension and proteinuria. This status can be further complicated by eclamptic seizures. Preeclampsia is among the leading causes of mortality in mothers, fetuses and newborns around the world. The exact mechanism causing preeclampsia has much been controversial and has not yet fully known. The current study sought to identify the diagnostic value of changes in the serum levels of placental growth factor in predicting the occurrence of preeclampsia. Materials and Methods: Serum samples were taken from 700 mothers who were between 8 to 12 weeks of pregnancy. Placental growth factor levels were compared and examined in 35 healthy pregnant women and 35 pregnant women with preeclampsia who were randomly selected. Results: Serum concentration of placental growth factor had a significant difference between healthy pregnant women and pregnant women with preeclampsia (P<0.05). Based on the results of the present study, placental growth factor has 57% sensitivity, 77% specificity, 71% positive predictive power and 64% negative predictive power in predicting the occurrence of preeclampsia. Conclusion: Serum levels of placental growth factor in the first trimester of pregnancy can be used to predict the occurrence of preeclampsia.

preeclampsia placental growth factor predict

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[1]  Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap III LC, Wenstrom KD. William's obstetrics. 22nd ed. New York: McGraw-Hill. 2005; p. 762-763.
[2]  Gharekhani P, Sadatian SA. Principles of Obstetrics and Pregnancy. 2nd ed. Tehran: Noure Danesh. 2005; p.416-22.
[3]  Kaypour F, Masomirad h, Ranjbar Novin N. The predictive value of serum uric acid, roll-overtest, and body mass index in pre-eclampsia. Int J Gynecol Obstet 2006; 92: 133-4.
[4]  Barker PN, Kingdom JCP. Pre-eclampsia: Current Perspectives on Management. 1st ed. New York: Parthenon Publishing Group. 2004; p. 25-35.
[5]  Roiz-Hernández J, Cabello-Martínez M, Fernández M. Human chorionic gonadotropin levels between 16 and 21 weeks of pregnancy and prediction of pre eclampsia. Int J Gynecol Obstet. 2006; 92: 101-105.
[6]  Hoque MM, Bulbul T, Mahal M, Islam NA, Ferdausi M. Serum homocysteine in pre-eclampsia and eclampsia. Bangladesh Med Res Counc Bull. 2008; 34: 16-20.
[7]  Singh U, Gupta HP, Singh RK, Shukla M, Singh R, Mehrotra SS, et al. A study of changes in homocysteine levels during normal pregnancy and pre-eclampsia. J Indian Med Assoc. 2008; 106:503-505.
[8]  Ghorashi V, Sheikhvatan M. The relationship between serum concentration of free testosterone and preeclampsia. Endocrinol Pol J. 2008; 59: 390-392.
[9]  Troisi R, Potischman N, Roberts JM, Ness R, Cromblenholme W, Lykins D, et al. Maternal serum estrogens and androgen concentrations inpreeclamptic and uncomplicated pregnancies. Int J Epidemiology. 2003; 32: 455-460.
[10]  Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, Thadhani R. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol 2001; 98: 757-762.
[11]  Heilmann L, Rath W, Pollow K. Hemorheological changes in women with severe preeclampsia.Clin Hemorheol Microcirc. 2004; 31: 49-58.
[12]  Hatfield A, Robinson E. The 'debriefing' of clients following the birth of a baby. Pract Midwife. 2002; 5: 14-6.
[13]  Hermida RC, Ayala DE, Iglesias M. Predictable blood pressure variability in healthy and complicated pregnancy. Hypertension. 2001; 38: 736-41.
[14]  Vural P, Akgul C, Canbaz M. Calcium and phosphate excretion in preeclampsia. Turk J Med Sci. 1999; 30: 39-42.
[15]  Bdolah Y, Karumanchi SA, Sachs BP. Recent advances in understanding of preeclampsia. Croat Med J. 2005 Oct. 46:728-36.
[16]  Baumann MU, Bersinger NA, Surbek DV. Serum markers for
[17]  De Vivo A, Baviera G, Giordano D, Todarello G, Corrado F, D'anna R. Endoglin, PlGF and sFlt-1 as markers for predicting pre-eclampsia. Acta Obstet Gynecol Scand. 2008;87:837-842.
[18]  Wikström AK, Larsson A, Eriksson UJ, Nash P, Nordén-Lindeberg S, Olovsson M. Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia. Obstet Gynecol. 2007; 109: 1368-1374.
[19]  Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension. 2007; 49: 818-824.
[20]  Gonzales AL, Ulloa Galvan G, Alpuche G, RomeroArauz JF. Risk factors for pre-eclampsia, Multi variate analysis. Gynecol Obstet Mex. 2000; 68: 357-62.