Journal of Polymer and Biopolymer Physics Chemistry
ISSN (Print): 2373-3403 ISSN (Online): 2373-3411 Website: http://www.sciepub.com/journal/jpbpc Editor-in-chief: Martin Alberto Masuelli
Open Access
Journal Browser
Go
Journal of Polymer and Biopolymer Physics Chemistry. 2019, 7(1), 1-9
DOI: 10.12691/jpbpc-7-1-1
Open AccessArticle

The Characterization of Poly n-Vinyl Pyrrolidone-Polyvinyl Acetate (PVP-PVAc) Copolymers and Blends by Nuclear Magnetic Resonance Spectroscopy, Fourier Transform Infrared Spectroscopy, and Elemental Analysis

Ronald P. D’Amelia1, , Joseph Mancuso1 and William Nirode1

1Chemistry Department, Hofstra University, Hempstead, NY

Pub. Date: June 01, 2019

Cite this paper:
Ronald P. D’Amelia, Joseph Mancuso and William Nirode. The Characterization of Poly n-Vinyl Pyrrolidone-Polyvinyl Acetate (PVP-PVAc) Copolymers and Blends by Nuclear Magnetic Resonance Spectroscopy, Fourier Transform Infrared Spectroscopy, and Elemental Analysis. Journal of Polymer and Biopolymer Physics Chemistry. 2019; 7(1):1-9. doi: 10.12691/jpbpc-7-1-1

Abstract

The determination of the composition of PVP-PVAc copolymers and blends is essential for knowing their polymeric properties and appropriate applications. In order to create a streamlined way to quantify the composition of PVP-PVAc copolymers and blends, the qNMR methodology alongside FTIR and elemental analysis were used to develop calibration curves for industrial use. We report on the methodologies used to determine % PVP content in the copolymers and blends in question as well as the results obtained via NMR, FTIR, and elemental analysis. Results from the NMR analysis were corroborated with calibration curves used to determine % PVP composition using FTIR and were further corroborated with elemental analysis results. The PVP-PVAc copolymers used ranged from 30 to 70 mol% PVP and the blends ranged from 20 to 80 weight% PVP.

Keywords:
quantitative analysis Nuclear Magnetic Resonance elemental analysis Fourier Transform Infrared Spectroscopy n-vinyl pyrrolidone - vinyl acetate copolymer and blends

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

Figure of 13

References:

[1]  Gebel, M.E., Kaleuati, M. A., Finlayson-Pitts, B. J. "Measurement of the Organics using Three FTIR Techniques: Absorption, Attenuated Total Reflectance, and Diffuse Reflectance”, J. Chem. Ed., 80 (6), 672-675, June 2003.
 
[2]  Lutz, J, Matyjaszewski, K “Nuclear Magnetic Resonance Monitoring of Chain-End Functionality in the Atom Transfer Radical Polymerization of Styrene”, J. Polymer Sci. January 2005.
 
[3]  Veening, H., “Quantitative Infrared Analysis of Xylene Mixtures: Internal Standard Method”, J. Chem. Ed., 46 (6), 319-320, June 1966.
 
[4]  Hu, W, Mao, J, Schmidt-Rohr, K, Xing, B “Poly(methylene) Crystallites in Humic Substances Detected by Nuclear Magnetic Resonance” Environ. Sci. Technol. December 1999.
 
[5]  Silverstein, R.M., Webster F.X., Spectrometer Identification of Organic Compounds, 7th edition, Wiley & Sons, New Jersey, December 2011.
 
[6]  Robinson J.W., Frame E.M.S., Frame ll G.M., Undergraduate Instrumental Analysis, 7th edition, CRC Press –Taylor Francis, Boca Raton, Florida, chapter 4, July 2014
 
[7]  Schuttlefield, J.D.; Grassian, V.H., "ATR-FTIR Spectroscopy in the Undergraduate Chemistry Laboratory”, J. Chem. Educ., 85 (2), 279-281, February 2008.
 
[8]  Lambert J.B., Gronert S., Shurvell H.F., Lightner D., Organic Structural Spectroscopy, 2nd, edition, Prentice Hall, New Jersey, October 2010.
 
[9]  Smith iv, R.E., McKee, J.R., Zanger, M. "The Electrophilic Bromination of Toluene: Determination of the Ortho, Meta, Para, ratios by Quantitative FTIR Spectroscopy”, J. Chem. Ed., 79 (2), 227-229, February 2002.
 
[10]  Betageri, G, Kadajji, V, “Water Soluble Polymers for Pharmaceutical Applications” Polymers, 3 November 2011
 
[11]  Forster, A, Hempenstall, J, Rades, T “Characterization of Glass Solutions of Poorly Water-Soluble Drugs Produced by Melt Extrusion with Hydrophilic Amorphous Polymers.” J. Pharm. Pharmcol. January 2001
 
[12]  Jijun, F, Lishuang, X, Xioli, W, Shu, Z, Xiaoguang, T, Xingna, Z, Haibing, H, Xing, T “Nimodipine (NM) Tablets with High Dissolution Containing NM Solid Dispersions Prepared by Hot-Melt Extrusion.” Drug Dev. Ind. Pharm. March 2011
 
[13]  He, H, Yang, R, Tang, X “In Vitro and in Vivo Evaluation of Fenofibrate Solid Dispersion Prepared by Hot-Melt Extrusion.” Drug Dev. Ind. Pharm May 2010
 
[14]  Chokshi, R.J., Sandhu, H.K., Iyer, R.M., Shah, N.H, Malick, W.A., Zia, H “Characterization of Physico-Echanical Properties of Indomethacin and Polymers to Assess their Suitability for Hot-Melt Extrusion Process as a Means to Manufacture Solid Dispersion/Solution” J. Pharm. Sci. November 2005
 
[15]  U.S. Food and Drug Administration Center for Food Safety & Applied Nutrition (CFSAN). Voluntary Cosmetic Registration Program - Frequency of Use of Cosmetic Ingredients. College Park, MD, 2018. Obtained under the Freedom of Information Act from CFSAN; requested as "Frequency of Use Data" January 3 2018; received February 5 2018).
 
[16]  Personal Care Products Council. 2017. Concentration of use by FDA product category - Vinylpyrrolidone Polymers. Unpublished data submitted by the Personal Care Products Council on October 2, 2017.
 
[17]  Rothe H, Fautz R, Gerber E, Neumann L, Rettinger K, Schuh W, and Gronewold C. “Special aspects of cosmetic spray safety evaluations: Principles on inhalation risk assessment.” Toxicol Lett. 2011;205(2):97-104
 
[18]  Bremmer HJ, Prud'homme de Lodder LCH, and van Engelen JGM. “Cosmetics Fact Sheet: To assess the risks for the consumer”; Updated version for ConsExpo 4. 20200
 
[19]  Johnsen MA. “The Influence of Particle Size. Spray Technology and Marketing.” 2004;14(11):24-27.
 
[20]  EFSA Panel on Food Additives and Nutrient Sources Added to Food (ANS). “Scientific opinion on the safety of polyvinylpyrrolidone-vinyl acetate copolymer for the proposed uses as a food additive.” January 2010, EFSA Journal.