World Journal of Nutrition and Health
ISSN (Print): 2379-7819 ISSN (Online): 2379-7827 Website: http://www.sciepub.com/journal/jnh Editor-in-chief: Srinivas NAMMI
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World Journal of Nutrition and Health. 2014, 2(3), 35-38
DOI: 10.12691/jnh-2-3-2
Open AccessReview Article

Free Radicals and Antioxidants: Role of Enzymes and Nutrition

Ahmed M Kabel1, 2,

1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia

2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt

Pub. Date: October 12, 2014

Cite this paper:
Ahmed M Kabel. Free Radicals and Antioxidants: Role of Enzymes and Nutrition. World Journal of Nutrition and Health. 2014; 2(3):35-38. doi: 10.12691/jnh-2-3-2

Abstract

Free radicals are substances normally produced by the human body as one of the defense mechanisms against harmful substances. When the rate of their production exceeds the antioxidant capacity of the body, oxidative stress occurs. Oxidative stress carries harmful effects to all the body systems and is implicated in the pathogenesis of various diseases including hypertension, atherosclerosis, diabetes mellitus and cancer. Enzymatic and non-enzymatic antioxidants play an important role in protection of the body against the harmful effec ts of free radicals.

Keywords:
free radicals antioxidants enzymes nutrition

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References:

[1]  Halliwell B (2007): Biochemistry of oxidative stress. Biochem Soc Trans; 35: 1147-50.
 
[2]  Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M et al. (2007): Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol; 39 (1): 44-84.
 
[3]  Bahorun T, Soobrarree MA, Luximon-Ramma V, Aruoma OI (2006): Free radicals and antioxidants in cardiovascular health and disease. Internet J Med Update; 1: 1-17.
 
[4]  Genestra M (2007): Oxyl radicals, redox-sensetive signaling cascades and antioxidants. Cell Signal; 19: 1807-1819.
 
[5]  Miranda-Vilelaa AL, Portilhoa FA, de Araujoa V, Estevanatoa L, Mezzomoa B, Santosb M, Lacavaa Z (2011): The protective effects of nutritional antioxidant therapy on Ehrlich solid tumorbearing mice depend on the type of antioxidant therapy chosen: histology, genotoxicity and hematology evaluations. J Nutr Biochem; 22 (11): 1091-1098.
 
[6]  Jomova K, Valko M (2011): Advances in metal-induced oxidative stress and human disease. Toxicol; 283 (2-3): 65-87.
 
[7]  Duarte TL, Lunec J (2005): When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radic Res; 39 (7): 671-86.
 
[8]  Zelko I, Mariani T, Folz R (2002): Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med; 33 (3): 337-49.
 
[9]  Johnson F, Giulivi C (2005): Superoxide dismutases and their impact upon human health. Mol Aspects Med 26 (4-5): 340-52.
 
[10]  Nozik-Grayck E, Suliman H, Piantadosi C (2005): Extracellular superoxide dismutase. Int J Biochem Cell Biol; 37 (12): 2466-71.
 
[11]  Berg JM, Tymoczko JL, Stryer L (2002): Biochemistry, 5th ed., Freeman WH and Co., New York; pp: 205-206.
 
[12]  Kabel AM, Abdel-Rahman MN, El-Sisi Ael-D, Haleem MS, Ezzat NM, El Rashidy MA (2013): Eur J Pharmacol; 713 (1-3): 47-53.
 
[13]  Ho YS, Xiong Y, Ma W, Spector A and Ho DS (2004): Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem; 279: 32804-32812.
 
[14]  Yang H, Shi MJ, Van Remmen H, Chen XL, Vijg J et al. (2003): Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice Am J Hypertens; 16 (1): 1-5.
 
[15]  Nordberg J, Arner ES (2001): Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med; 31 (11): 1287-1312.
 
[16]  Mustacich D, Powis G (2000): . Biochem J; 346(1): 1-8.
 
[17]  Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi Y (2004): Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal; 6 (2): 289-300.
 
[18]  Hayes J, Flanagan J, Jowsey I (2005): Glutathione transferases. Annu Rev Pharmacol Toxicol; 45: 51-88.
 
[19]  Linster CL, Van Schaftingen E (2007): Vitamin C: Biosynthesis, recycling and degradation in mammals. FEBS J; 274 (1): 1-22.
 
[20]  Ulusu NN, (2007): Purification and kinetic properties of glutathione reductase from bovine liver. ; 303(1-2): 45-51.
 
[21]  Sen C, Khanna S, Roy S (2006): . Life Sci; 78 (18): 2088-2098.