World Journal of Nutrition and Health
ISSN (Print): 2379-7819 ISSN (Online): 2379-7827 Website: http://www.sciepub.com/journal/jnh Editor-in-chief: Srinivas NAMMI
Open Access
Journal Browser
Go
World Journal of Nutrition and Health. 2014, 2(2), 28-32
DOI: 10.12691/jnh-2-2-4
Open AccessReview Article

Management of Keloids and Hypertrophic Scars: Role of Nutrition, Drugs, Cryotherapy and Phototherapy

Ibrahim A Maghrabi1 and Ahmed M Kabel2, 3,

1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia

2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt

3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taif University, Taif, Saudi Arabia

Pub. Date: August 29, 2014

Cite this paper:
Ibrahim A Maghrabi and Ahmed M Kabel. Management of Keloids and Hypertrophic Scars: Role of Nutrition, Drugs, Cryotherapy and Phototherapy. World Journal of Nutrition and Health. 2014; 2(2):28-32. doi: 10.12691/jnh-2-2-4

Abstract

Keloids and hypertrophic scars are characterized by excessive deposition of dermal collagen with resultant scar tissue. This scar tissue is benign, non-contagious and sometimes accompanied by severe itching, sharp pains and changes in texture. In severe cases, it can affect movement of skin and may ulcerate. There are various lines of treatment of keloids and hypertrophic scars including nutritional therapy, drug therapy, radiation therapy, phototherapy cryotherapy and surgical excision.

Keywords:
management keloids hypertrophic scars

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Davison SP, Mess S, Kauffman LC, et al. (2006): Ineffective treatment of keloids with interferon alpha-2b. Plast Reconstr Surg., 117(1): 247-252.
 
[2]  Al-Attar A, Mess S, Thomassen JM et al. (2006): Keloid pathogenesis and treatment. Plast Reconstr Surg., 117(1): 286-300.
 
[3]  Alster TS, Tanzi EL (2003): Hypertrophic scars and keloids: etiology and management. Am J Clin Dermatol., 4(4): 235-243.
 
[4]  Kakar AK, Shahzad M, Haroon TS (2006): Keloids: clinical features and management. J Pakis Assoc Dermatol., 16: 97-103.
 
[5]  Butler PD, Longaker MT, Yang GP (2008): Current Progress in Keloid: Research and Treatment. J Amer College Surg., 206(4): 731-741.
 
[6]  Mrowietz U, Seifert O (2009): Keloid Scarring: New Treatments Ahead. Actas Dermo-Sifiliográficas., 100 (2): 75-83.
 
[7]  Berman B, Viera MH, Amini S, et al. (2008): Prevention and management of hypertrophic scars and keloids after burns in children. J Craniofac Surg.,19(4): 989-1006.
 
[8]  Fitzpatrick RE (1999): Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg., 25: 224-232.
 
[9]  Margaret Shanthi FX, Ernest K, Dhanraj P (2008): Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids. Indian J Dermatol Venereol Leprol., 74(4): 343-348.
 
[10]  Lee JH, Kim SE and Lee AY (2008): Effects of interferon-alpha2b on keloid treatment with triamcinolone acetonide intralesional injection. Int J Dermatol., 47(2):183-186.
 
[11]  Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. (2005): Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol., 52(3): 474-479.
 
[12]  Nanda S, Reddy BS (2004): Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Surg., 30(1): 54-56.
 
[13]  Asilian A, Darougheh A, Shariati F (2006): New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg., 32(7): 907-915.
 
[14]  Saray Y, Güleç AT (2005): Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol., 44(9): 777-784.
 
[15]  Muszynska A, Palka J, Gorodkiewicz E (2000): The mechanism of daunorubicin-induced inhibition of prolidase activity in human skin fibroblasts and its implication to impaired collagen biosynthesis. Exp Toxicol Pathol., 52(2): 149-155.
 
[16]  Muszynska A, Wolczynski S, Palka J (2001): The mechanism for anthracycline-induced inhibition of collagen biosynthesis. Eur J Pharmacol., 411(1-2): 17-25.
 
[17]  España A, Solano T, Quintanilla E (2001): Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg., 27(1): 23-27.
 
[18]  Copcu E, Sivrioglu N, Oztan Y (2004): Combination of surgery and intralesional verapamil injection in the treatment of the keloid. J Burn Care Rehabil., 25(1): 1-7.
 
[19]  Kim A, DiCarlo J, Cohen C, et al. (2001): Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids. J Am Acad Dermatol., 45(5): 707-711.
 
[20]  Mikulec AA, Hanasono MM, Lum J, et al. (2001): Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts. Arch Facial Plast Surg., 3(2): 111-114.
 
[21]  Saulis AS, Mogford JH, Mustoe TA (2002): Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plast Reconstr Surg., 110(1): 177-183.
 
[22]  Occleston NL, O’Kane S, Goldspink N, et al. (2008): New therapeutics for the prevention and reduction of scarring. Drug Discovery Today, 13(21): 973-981.
 
[23]  Draelos ZD (2008): The ability of onion extract gel to improve the cosmetic appearance of postsurgical scars. J Cosmet Dermatol., 7(2):101-104.
 
[24]  Koc E, Arca E, Surucu B, et al. (2008): An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg., 34(11): 1507-1514.
 
[25]  Hosnuter M, Payasli C, Isikdemir A, et al. (2007): The effects of onion extract on hypertrophic and keloid scars. J Wound Care., 16(6): 251-254.
 
[26]  Garg MK, Weiss P, Sharma AK, et al. (2004): Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol., 73(2): 233-236.
 
[27]  Bijlard E, Timman R, Verduijn GM, et al. (2013): Intralesional cryotherapy versus excision and corticosteroids or brachytherapy for keloid treatment: study protocol for a randomised controlled trial. Trials., 14:439.
 
[28]  Martin MS, Collawn SS (2013): Combination treatment of CO2 fractional laser, pulsed dye laser, and triamcinolone acetonide injection for refractory keloid scars on the upper back. J Cosmet Laser Ther., 15(3): 166-70.
 
[29]  Chiu LL, Sun CH, Yeh AT, et al. (2005): Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-culture. Lasers Surg Med., 37(3): 231-244.
 
[30]  Oiso N, Kawara S and Kawada A (2008): The effectiveness of narrowband ultraviolet B on hypertrophic scar in a patient having an isomorphic phenomenon and vitiligo. J Eur Acad Dermatol Venereol., 22 (12): 1527-1535.
 
[31]  Taylor DK, Anstey AV, Coleman AJ, et al. (2002): Guidelines for dosimetry and calibration in ultraviolet radiation therapy: a report of a British photodermatology group workshop. BJD., 146 (5): 755-763.
 
[32]  Shamsi Meymandi S, Rezazadeh A, Ekhlasi A (2014): Studying intense pulsed light method along with corticosteroid injection in treating keloid scars. Iran Red Crescent Med J., 16(2):e12464.
 
[33]  Erol OO, Gurlek A, Agaoglu G, et al. (2008): Treatment of hypertrophic scars and keloids using intense pulsed light (IPL). Aesthetic Plast Surg., 32(6): 902-909.