Process Study of Anti-Malaria Product from Artemisia Annua

Seid Yimer¹ and Omprakash Sahu^1,

¹Department of Chemical Engineering, KIOT, Wollo University, Ethiopia

Cite this paper:
Seid Yimer and Omprakash Sahu. Process Study of Anti-Malaria Product from Artemisia Annua. World Journal of Nutrition and Health. 2014; 2(1):10-16. doi: 10.12691/jnh-2-1-2

Abstract

Malaria disease is endemic in least developed countries like Ethiopia. This disease is caused by protozoa of the genus Plasmodium infection that is easily recognizable from the symptoms of prolonged fever. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The plant Artemisia annua is the sole source of artemisinin in the industry. The main objective of the project was to provide a simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from the plant Artemisia annua Furthermore, this work was focus on the mass and energy balance calculation of the antibiotic Artemisia annua in the large scale industry.

Keywords:
Artemisia annua L. extraction feasibility hexane malaria sesquiterpene lactone

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References:

[1]	Fabricant, D. S., and Farnsworth, N. R., The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives. National Institute of Environmental Health Science 109(2001): 69-75.
[2]	Cos, P., Vlietinck, A. J., Berghe, D. V., and Maes, L., Anti-infective potential of natural products: how to develop a stronger in vitro “proof-of-concept”, Journal of Ethnopharmacology 106 (2006):290-302.
[3]	Hsu E., The history of qing hao in the Chinese materia medica. Trans. Roy. Soc. Trop. Med. Hyg. 100(2006): 505-508.
[4]	Gebeyaw Tiruneh, Yigzaw Kebede, Tegbar Yigzaw, “Use of Plant Artémisia annua as a natural anti-malarial Herb in Arbaminch Town (Ethiopia)”, J. Health Biomed Science, 2010. Vol.2, No.2
[5]	D. Sánchez, S. Quispe, P. Rosa, M. A. A. Meireles, C. Zetzl, G. Brunner; Extraction of the Antimalarial Artemisinin from Artemisia Annua L. Leaves with Supercritical CO2: Project integrated in the German-Brazil program “SUPERNAT”.
[6]	Ahmed M, Determination of Artemisinin and essential oil contents of Artemisia annua L. grown in Ethiopia and In vivo Antimalarial activity of its crude extracts against Plasmodium berghei in mice, Addis Ababa University. (2008).
[7]	Abebe, D, Ayehu, A, Medicinal plants and enigmatic health practice of Northern Ethiopia, Berhanena selam printing Enterprise, Addis Ababa (2013).
[8]	Govindarajan, R., Vijayakumar, M., and Pushpangadan, P., Antioxidant approach to disease management and the role of “Rasayana” herbs of Ayurveda. Journal of Ethnopharmacology 99(2005): 165-178.
[9]	Lombardino, J. G., and Lowe, J. A. The role of the medicinal chemist in drug discovery - then and now, Nature Reviews Drug Discovery 3(2010): 853-862.
[10]	Coulson J.M., Richardson J.F., Coulson and Richardson’s chemical engineering, volume 2, 3rd edition. 1995.
[11]	Newman, D. J., Cragg, G. M., and Snader, K. M., The influence of natural products upon drug discovery., Natural Product Reports. The Royal Society of Chemistry 17(2009): 215-234.
[12]	Subapriya, R., and Nagini, S. Medicinal properties of neem leaves: a review. Current medicinal chemistry Anticancer agents 5(2005): 149-146.
[13]	Aikawa, M. The fine structure of the erythrocytic stages of three avian malarial parasites, Plasmodium fallax, P. lophurae, and P. cathemerium., The American Journal of Tropical Medicine and Hygiene 15(2006) 449-471.
[14]	Dondorp, A. M., Kager, P. A., Vreeken, J., and White, N. J. Abnormal blood flow and red blood cell deformability in severe malaria., Parasitology today Personal ed 16(2009): 228-32.
[15]	Geysen, H.M., Schoenen, F., Wagner, D., Wagner, R. Combinatorial compound libraries for drug discovery: an ongoing challenge. Nat. Rev. Drug Discovery 2 (3), (2002): 222-230.
[16]	Romero, M.R., Effeth, T., Serrano, M.A., Castano, B., Macias, R.I., Briz, O & Martin, J.J., Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an ‘in vitro’ system. Antiviral Res. 68(2005): 75-83.
[17]	Tilak, K. V. B. R., N. Ranganayaki, K. K. Pal, R.De, A. K. Saxena, C. Shekhar Nautiyal, Shilipi Mittal, A. K. Tripathi & B. N. Johri. Diversity of plant growth and soil health supporting bacteria. Current Science. 89(2010): 136-150.