World Journal of Nutrition and Health
ISSN (Print): 2379-7819 ISSN (Online): 2379-7827 Website: Editor-in-chief: Srinivas NAMMI
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World Journal of Nutrition and Health. 2020, 8(1), 16-21
DOI: 10.12691/jnh-8-1-4
Open AccessArticle

Nutritional Impact of COVID-19 and Its Implications on Atherosclerosis

I.C. Esobi1, , M. K. Lasode2, C. I Anyanwu2, E. Degbe3, M.O Flores Barriguete4, M. A. Okorie5, D. O. Lasode6 and S. Okegbe7

1Department of Food, Nutrition and Packaging Science, Clemson University, Clemson, South Carolina, USA

2Department of Geography, Texas State University, San Marcos, Texas, USA

3Department of Mathematical and Statistical Sciences, Clemson University, Clemson, South Carolina, USA

4El Pasoans Fighting Hunger Food Bank, El Paso, Texas, USA

5College of Nursing, Chamberlain University, San Antonio, Texas, USA

6Africa Regional Centre for Information Science, University of Ibadan, Oyo State, Nigeria

7Department of Communication, University of Illinois, Urbana-Champaign, Illinois, USA

Pub. Date: November 29, 2020

Cite this paper:
I.C. Esobi, M. K. Lasode, C. I Anyanwu, E. Degbe, M.O Flores Barriguete, M. A. Okorie, D. O. Lasode and S. Okegbe. Nutritional Impact of COVID-19 and Its Implications on Atherosclerosis. World Journal of Nutrition and Health. 2020; 8(1):16-21. doi: 10.12691/jnh-8-1-4


The coronavirus disease 2019 (COVID-19) pandemic has affected people from every part of the world, with the elderly and minority groups being at a higher risk owing to the high prevalence of underlying health conditions such as atherosclerosis among these groups. This study discusses numerous implications of the COVID-19 pandemic on people consuming more unhealthy foods due to restricted access to stores and stores closing early. A lot of people currently live a sedentary lifestyle because of the strenuous quarantine measures. COVID-19 impacts the nutritional status of people leaving them at risk of atherosclerosis and worsens the health condition of individuals suffering from it. Also, the use of COVID-19 medications has been observed to have side effects in patients with atherosclerosis. Thus, we review the nutritional impact of COVID-19 and its implications on atherosclerosis at length and make recommendations for reducing future implications. This study would serve as a foundation for further research on COVID-19 and its implications on atherosclerosis as only a limited number of studies have addressed it.

atherosclerosis COVID-19 Sars-CoV-2 cardiovascular disease heart failure

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[1]  Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., Alla, F., Alvis-Guzman, N., Amrock, S., Ansari, H., Ärnlöv, J., Asayesh, H., Atey, T. M., Avila-Burgos, L., Awasthi, A., … Murray, C. (2017). Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. Journal of the American College of Cardiology, 70(1), 1-25.
[2]  Ross, R. (1999). Atherosclerosis—an inflammatory disease. New England journal of medicine, 340(2), 115-126.
[3]  Kim, J. Y., Park, H. J., Um, S. H., Sohn, E. H., Kim, B. O., Moon, E. Y., ... & Pyo, S. (2012). Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways. Vascular pharmacology, 56(3-4), 131-141.
[4]  Frostegård, J. (2013). Immunity, atherosclerosis and cardiovascular disease. BMC medicine, 11(1), 1-13.
[5]  Torres, N., Guevara-Cruz, M., Velázquez-Villegas, L. A., & Tovar, A. R. (2015). Nutrition and Atherosclerosis. Archives of Medical Research, 46(5), 408-426.
[6]  Herrington, W., Lacey, B., Sherliker, P., Armitage, J., & Lewington, S. (2016). Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circulation research, 118(4), 535-546.
[7]  Santos, M. G. D., Pegoraro, M., Sandrini, F., & Macuco, E. C. (2008). Risk factors for the development of atherosclerosis in childhood and adolescence. Arquivos brasileiros de cardiologia, 90(4), 301-308.
[8]  Gori, T., Lelieveld, J., & Münzel, T. (2020). Perspective: cardiovascular disease and the Covid-19 pandemic. Basic Research in Cardiology, 115(3), 1-4.
[9]  Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020). COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nature Reviews Cardiology, 17(9), 543-558.
[10]  Vinciguerra, M., Romiti, S., Fattouch, K., De Bellis, A., & Greco, E. (2020). Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm. Journal of Clinical Medicine, 9(7), 2095.
[11]  Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., ... & Chen, H. D. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. nature, 579(7798), 270-273.
[12]  Bikdeli, B., Madhavan, M. V., Jimenez, D., Chuich, T., Dreyfus, I., Driggin, E., ... & Tang, L. V. (2020). COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 75(23), 2950-2973.
[13]  Connors, J. M., & Levy, J. H. (2020). Thromboinflammation and the hypercoagulability of COVID-19. Journal of Thrombosis and Haemostasis.
[14]  Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology, 1-12.
[15]  Ridker, P. M., & Lüscher, T. F. (2014). Anti-inflammatory therapies for cardiovascular disease. European heart journal, 35(27), 1782-1791.
[16]  Ridker, P. M. (2016). From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection. Circulation research, 118(1), 145-156.
[17]  Cai, T., Zhang, Y., Ho, Y. L., Link, N., Sun, J., Huang, J., ... & Costa, L. (2018). Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: a phenome-wide association study. JAMA cardiology, 3(9), 849-857.
[18]  Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., ... & Chen, R. (2018). Research progress on the relationship between atherosclerosis and inflammation. Biomolecules, 8(3), 80.
[19]  Lin, L., Lu, L., Cao, W., & Li, T. (2020). Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerging microbes & infections, 9(1), 727-732.
[20]  Sohrabi, C., Alsafi, Z., O’Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., ... & Agha, R. (2020). World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). International Journal of Surgery.
[21]  Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., ... & Niu, P. (2020). A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine.
[22]  Mattioli, A. V., Ballerini Puviani, M., Nasi, M., & Farinetti, A. (2020). COVID-19 pandemic: the effects of quarantine on cardiovascular risk. European Journal of Clinical Nutrition, 74(6), 852–855.
[23]  Blendon, R. J., Benson, J. M., DesRoches, C. M., Raleigh, E., & Taylor-Clark, K. (2004). The public's response to severe acute respiratory syndrome in Toronto and the United States. Clinical infectious diseases, 38(7), 925-931.
[24]  Siti, H. N., Kamisah, Y., & Kamsiah, J. (2015). The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascular pharmacology, 71, 40-56.
[25]  Butler, M. J., & Barrientos, R. M. (2020). The impact of nutrition on COVID-19 susceptibility and long-term consequences. Brain, Behavior, and Immunity.
[26]  Qiu, H., Wu, J., Hong, L., Luo, Y., Song, Q., & Chen, D. (2020). Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. The Lancet Infectious Diseases.
[27]  Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., ... & Brand-Miller, J. (2005). Origins and evolution of the Western diet: health implications for the 21st century. The American journal of clinical nutrition, 81(2), 341-354.
[28]  Connaughton, R. M., McMorrow, A. M., McGillicuddy, F. C., Lithander, F. E., & Roche, H. M. (2016). Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood. Proceedings of the Nutrition Society, 75(2), 115-124.
[29]  Mattioli, A. V., Sciomer, S., Moscucci, F., Maiello, M., Cugusi, L., Gallina, S., ... & Barilla, F. (2019). Cardiovascular prevention in women: a narrative review from the Italian Society of Cardiology working groups on ‘Cardiovascular Prevention, Hypertension and peripheral circulation’and on ‘Women Disease’. Journal of Cardiovascular Medicine, 20(9), 575-583.
[30]  Nasi, M., Patrizi, G., Pizzi, C., Landolfo, M., Boriani, G., Dei Cas, A., ... & Capucci, A. (2019). The role of physical activity in individuals with cardiovascular risk factors: an opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-Sport. Journal of Cardiovascular Medicine, 20(10), 631-639.
[31]  Karbach, S., Wenzel, P., Waisman, A., Munzel, T., & Daiber, A. (2014). eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation. Current pharmaceutical design, 20(22), 3579-3594.
[32]  Peiris, J. S. M., Chu, C. M., Cheng, V. C. C., Chan, K. S., Hung, I. F. N., Poon, L. L., ... & Chan, K. H. (2003). Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. The Lancet, 361(9371), 1767-1772.
[33]  Madjid, M., Safavi-Naeini, P., Solomon, S. D., & Vardeny, O. (2020). Potential effects of coronaviruses on the cardiovascular system: a review. JAMA cardiology.
[34]  Clerkin, K. J., Fried, J. A., Raikhelkar, J., Sayer, G., Griffin, J. M., Masoumi, A., ... & Schwartz, A. (2020). COVID-19 and cardiovascular disease. Circulation, 141(20), 1648-1655.
[35]  Zhao, X., Zhang, B., Li, P., Ma, C., Gu, J., Hou, P., ... & Bai, Y. (2020). Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis. MedRxiv.
[36]  Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020). The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovascular research, 116(6), 1097-1100.
[37]  Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., ... & Du, B. (2020). Clinical characteristics of coronavirus disease 2019 in China. New England journal of medicine, 382(18), 1708-1720.
[38]  Shi, S., Qin, M., Shen, B., Cai, Y., Liu, T., Yang, F., ... & Huang, H. (2020). Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA cardiology.
[39]  Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., ... & Zhao, Y. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama, 323(11), 1061-1069.
[40]  Li, G., Hu, R., & Gu, X. (2020). A close-up on COVID-19 and cardiovascular diseases. Nutrition, Metabolism and Cardiovascular Diseases.
[41]  Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., ... & Zhou, Y. (2020). Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. International journal of infectious diseases.
[42]  Ielapi, N., Licastro, N., Provenzano, M., Andreucci, M., Franciscis, S. D., & Serra, R. (2020). Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis.
[43]  Wu, Q., Zhou, L., Sun, X., Yan, Z., Hu, C., Wu, J., ... & Li, K. (2017). Altered lipid metabolism in recovered SARS patients twelve years after infection. Scientific reports, 7(1), 1-12.
[44]  Akhmerov, A., & Marbán, E. (2020). COVID-19 and the heart. Circulation research, 126(10), 1443-1455.
[45]  Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., Manson, J. J., & HLH Across Speciality Collaboration. (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet (London, England), 395(10229), 1033.
[46]  Kadosh, B. S., Garshick, M. S., Gaztanaga, J., Moore, K. J., Newman, J. D., Pillinger, M., ... & Fishman, G. I. (2020). COVID-19 and the Heart and Vasculature: Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2045-2053.
[47]  Bangalore, S., Sharma, A., Slotwiner, A., Yatskar, L., Harari, R., Shah, B., ... & Chadow, H. L. (2020). ST-segment elevation in patients with Covid-19--a case series. New England Journal of Medicine.
[48]  Doyen, D., Moceri, P., Ducreux, D., & Dellamonica, J. (2020). Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes. The Lancet, 395(10235), 1516.
[49]  Hu, H., Ma, F., Wei, X., & Fang, Y. (2020). Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. European heart journal.
[50]  Avula, Akshay, Krishna Nalleballe, Naureen Narula, Steven Sapozhnikov, Vasuki Dandu, Sudhamshi Toom, Allison Glaser, and Dany Elsayegh. "COVID-19 presenting as stroke." Brain, behavior, and immunity (2020).
[51]  Landa, N., Mendieta-Eckert, M., Fonda-Pascual, P., & Aguirre, T. (2020). Chilblain-like lesions on feet and hands during the COVID-19 Pandemic. International journal of dermatology, 59(6), 739.
[52]  Royal College of Paediatrics and Child Health. (2020). Guidance-Paediatric multisystem inflammatory syndrome temporally associated with COVID-19.
[53]  Whittaker, E., Bamford, A., Kenny, J., Kaforou, M., Jones, C. E., Shah, P., ... & Kucera, F. (2020). Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. Jama.
[54]  Jain, R., Young, M., Dogra, S., Kennedy, H., Nguyen, V., Jones, S., ... & Horwtiz, L. (2020). COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome. Journal of the Neurological Sciences, 116923.
[55]  Cugno, M., Meroni, P. L., Gualtierotti, R., Griffini, S., Grovetti, E., Torri, A., ... & Peyvandi, F. (2020). Complement activation in patients with COVID-19: A novel therapeutic target. Journal of Allergy and Clinical Immunology, 146(1), 215-217.
[56]  Goeijenbier, M., Van Wissen, M., Van De Weg, C., Jong, E., Gerdes, V. E. A., Meijers, J. C. M., ... & van Gorp, E. C. M. (2012). Viral infections and mechanisms of thrombosis and bleeding. Journal of medical virology, 84(10), 1680-1696.
[57]  Li, B., Yang, J., Zhao, F., Zhi, L., Wang, X., Liu, L., ... & Zhao, Y. (2020). Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clinical Research in Cardiology, 109(5), 531-538.
[58]  Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., ... & Guan, L. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet.
[59]  Esobi, I.C., Lasode, M.K., & Barriguete, M.O.F. (2020). The Impact of COVID-19 on Healthy Eating Habits. J Clin Nutr Heal, 1(1), 001-002.