Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2018, 6(6), 386-392
DOI: 10.12691/jfnr-6-6-6
Open AccessArticle

Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation

Emanuela Leoncini1, Cecilia Prata2, Marco Malaguti1, Cristina Angeloni3, Luca Massaccesi1, Sara Bosi4, Valeria Bregola4, Ilaria Marotti4, Giovanni Dinelli4 and Silvana Hrelia1,

1Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy

2Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy

3School of Pharmacy, University of Camerino, Camerino, Italy

4Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, 40127 Bologna, Italy

Pub. Date: June 20, 2018

Cite this paper:
Emanuela Leoncini, Cecilia Prata, Marco Malaguti, Cristina Angeloni, Luca Massaccesi, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli and Silvana Hrelia. Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation. Journal of Food and Nutrition Research. 2018; 6(6):386-392. doi: 10.12691/jfnr-6-6-6


The important functions of the endothelium and the relationship between cardiovascular risk factors and endothelial dysfunction suggest the primary role of this tissue as a target for dietary strategies aimed at the prevention from related diseases. Cereals are key component of a healthy and balanced diet, and the presence of non-specific lipid-transfer protein 2 (nsLTP2) in wheat represents an added value to contribute to maintain the functionality of the vascular endothelium and consequently of the cardiovascular system. Indeed, nsLTP2 downregulates the expression of the main cell adhesion molecules induced by a pro-inflammatory cytokine and, meanwhile, upregulates heme oxigenase-1, exerting a cytoprotective/anti-inflammatory activity. Therefore, nsLTP2 might represent a food-derived tool to protect the vascular system against several pathological conditions.

wheat bioactive peptides nsLTP2 vascular endothelium cytoprotection inflammation

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