Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2018, 6(4), 261-270
DOI: 10.12691/jfnr-6-4-9
Open AccessArticle

Study on Mechanisms Underlying the Preventive Effects of Canarium album L. ethanol Extract on Modulation of Hyperglycemia and Hypercholesterolemia in Diabetic Rats

Yu-Han Kao1, Yu-Te Yeh1, An-Na Chiang2 and Shu-Chen Hsieh1,

1Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan

2Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan

Pub. Date: May 04, 2018

Cite this paper:
Yu-Han Kao, Yu-Te Yeh, An-Na Chiang and Shu-Chen Hsieh. Study on Mechanisms Underlying the Preventive Effects of Canarium album L. ethanol Extract on Modulation of Hyperglycemia and Hypercholesterolemia in Diabetic Rats. Journal of Food and Nutrition Research. 2018; 6(4):261-270. doi: 10.12691/jfnr-6-4-9

Abstract

Canarium album L. has attracted attention for its high polyphenol content and various potential pharmacological activities, exhibiting potential to reduce the risk of metabolic disorders. We hypothesized that Canarium album L. may regulate glucose and lipid metabolic pathways. To examine the application potential of Canarium album L. on metabolism, we designed the present study to investigate the effect of Canarium album L. ethanol extract (CO-EtOH) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. Our data showed CO-EtOH significantly reduced elevated fasting blood glucose, TC, TNF-α, and bile acid. Administration of CO-EtOH increased hepatic mRNA levels of GLUT2 and GK but decreased those of PEPCK and G6Pase. Furthermore, CO-EtOH remarkably reduced hepatic levels of cholesterol; lowered the expression of genes involved in cholesterol biosynthesis, transportation, and degradation, including SREBP-2, HMG-CoAR, SR-B1, CYP7A1, BSEP, MRP3, MRP4, and NTCP; and decreased the expression of LDLR, ABCG8, FXR, and SHP that govern cholesterol transportation and bile acid synthesis. The protein expressions of LDLR, ABCA1, FXR, and SHP were also significantly increased upon CO-EtOH treatment. Finally, CO-EtOH could increase glucose uptake in rat skeletal muscle cells in both normal and palmitic acid-challenged conditions. These findings suggest that Canarium album L. may have great potential for treating hyperglycemia and hypercholesterolemia.

Keywords:
Canarium album L. type 2 diabetes high-fat diet cholesterol glucose uptake

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