Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2018, 6(3), 137-145
DOI: 10.12691/jfnr-6-3-1
Open AccessArticle

Assessing inflammation in obese patients using DII dietary inflammatory index – A pilot cross sectional study in Jeddah, Saudi Arabia in the year 2017

Noura M S Eid1, , Al-Rotana Albadri1, Kholoud Alshobragi1, Nadin Sharqawi1, Razan Albar1 and Abdulmalik Altaf2

1Faculty of Applied Medical Sciences, Department of Clinical Nutrition, King Abdulaziz University, Jeddah, Saudi Arabia

2Faculty of Medicine, Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia

Pub. Date: March 09, 2018

Cite this paper:
Noura M S Eid, Al-Rotana Albadri, Kholoud Alshobragi, Nadin Sharqawi, Razan Albar and Abdulmalik Altaf. Assessing inflammation in obese patients using DII dietary inflammatory index – A pilot cross sectional study in Jeddah, Saudi Arabia in the year 2017. Journal of Food and Nutrition Research. 2018; 6(3):137-145. doi: 10.12691/jfnr-6-3-1

Abstract

Obesity is associated with chronic low-grade inflammation caused by progressive infiltration in adipose tissue macrophage (increase M1 pro-inflammatory and decrease M2 anti-inflammatory). In this study, we aim to assess the inflammatory status of obese patients and the impact of using resveratrol as a therapeutic approach. A cross sectional trial on 10 patients from surgical word in KAUH were assessed by DII and blood test to measure there inflammatory status. In addition, a questionnaire is used to observe their social habits and medical history. Then an ex vivo study will be carried to assess the effect of resveratrol of adipose tissue macrophage. Results have shown that all volunteers had pro- inflammatory score of DII and high CRP. There was no association between types and amount of polyphenols intake and level of CRP, except flavonols was strongly associated negatively with CRP (p<0.05, R2= 0.425). DII can be used in the future as a new tool in the routine assessment of the inflammatory potential for the diet, which can be applied to obese population in Saudi Arabia. In the next step of this research, we will study the therapeutic application of resveratrol to treat obesity from inflammatory aspect.

Keywords:
obesity inflammation CRP diet inflammatory index polyphenols

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References:

[1]  Nguyen DM, El-Serag HB. The Epidemiology of Obesity. Gastroenterology Clinics. 39(1): 1-7.
 
[2]  Memish ZA, El Bcheraoui C, Tuffaha M, Robinson M, Daoud F, Jaber S. Obesity and Associated Factors - Kingdom of Saudi Arabia, 2013. Preventing Chronic Disease. 2014; 11: E174.
 
[3]  Finucane OM, Reynolds CM, McGillicuddy FC, Roche HM. Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance. Proc Nutr Soc. 2012; 71(4): 622-33.
 
[4]  Bullo M, Casas-Agustench P, Amigo-Correig P, Aranceta J, Salas-Salvado J. Inflammation, obesity and comorbidities: the role of diet. Public health nutrition. 2007; 10(10a): 1164-72.
 
[5]  Emanuela F, Grazia M, Marco de R, Maria Paola L, Giorgio F, Marco B. Inflammation as a Link between Obesity and Metabolic Syndrome. Journal of nutrition and metabolism. 2012; 2012: 476380.
 
[6]  center Wm. obesity and overweight 2015 [Available from: http://www.who.int/mediacentre/factsheets/fs311/en/.
 
[7]  Pi-Sunyer FX. Obesity: criteria and classification. Proc Nutr Soc. 2000; 59(4): 505- 9.
 
[8]  Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. British Journal of Nutrition. 2011; 106(SupplementS3): S1-S78.
 
[9]  Romeo GR, Lee J, Shoelson SE. Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(8): 1771-6.
 
[10]  Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117(1): 175-84.
 
[11]  Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. European cytokine network. 2006; 17(1): 4-12.
 
[12]  Wood IS, de Heredia FP, Wang B, Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proceedings of the Nutrition Society. 2009; 68(04): 370-7.
 
[13]  Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. The American journal of clinical nutrition. 2006; 83(2): 461s-5s.
 
[14]  Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. Journal of Clinical Investigation. 2006; 116(7): 1793-801.
 
[15]  Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46(11): 2347-55.
 
[16]  Coenen KR, Gruen ML, Chait A, Hasty AH. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes. 2007; 56(3): 564-73.
 
[17]  Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW, 2nd, DeFuria J, Jick Z, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007; 56(12): 2910-8.
 
[18]  Aron-Wisnewsky J, Tordjman J, Poitou C, Darakhshan F, Hugol D, Basdevant A, et al. Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss. The Journal of Clinical Endocrinology & Metabolism. 2009; 94(11): 4619-23.
 
[19]  Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes. 2009; 58(11): 2574-82.
 
[20]  Satoh N, Shimatsu A, Himeno A, Sasaki Y, Yamakage H, Yamada K, et al. Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: effect of pioglitazone. Diabetes Care. 2010; 33(1): e7.
 
[21]  Surmi BK, Hasty AH. Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future Lipidol. 2008; 3(5): 545-56.
 
[22]  Ando C, Takahashi N, Hirai S, Nishimura K, Lin S, Uemura T, et al. Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation. FEBS Letters. 2009; 583(22): 3649-54.
 
[23]  Kang JH, Kim CS, Han IS, Kawada T, Yu R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett. 2007; 581(23): 4389-96.
 
[24]  Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, et al. Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice. Diabetes. 2011; 60(4): 1246-57.
 
[25]  Overman A, Bumrungpert A, Kennedy A, Martinez K, Chuang CC, West T, et al. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int J Obes. 2010; 34(5): 800-8.
 
[26]  Min SY, Yang H, Seo SG, Shin SH, Chung MY, Kim J, et al. Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. Int J Obes (Lond). 2013; 37(4): 584-92.
 
[27]  Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public health nutrition. 2014; 17(8): 1689-96.
 
[28]  Del Rio D, Rodriguez-Mateos A, Spencer JPE, Tognolini M, Borges G, Crozier A Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases. Antioxid Redox Signal. 2013; 18(14): 1818- 92.
 
[29]  Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009; 150(4): 1688-96.
 
[30]  Wrieden W, Peace H, Armstrong J, Barton K, editors. A short review of dietary assessment methods used in National and Scottish Research Studies. Briefing Paper Prepared for: Working Group on Monitoring Scottish Dietary Targets Workshop Edinburgh; 2003.
 
[31]  Cavicchia PP, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, et al. A New Dietary Inflammatory Index Predicts Interval Changes in Serum High-Sensitivity CReactive Protein. The Journal of Nutrition. 2009; 139(12): 2365-72.
 
[32]  Buttari B, Profumo E, Segoni L, #x, Arcangelo D, Rossi S, et al. Resveratrol Counteracts Inflammation in Human M1 and M2 Macrophages upon Challenge with 7-Oxo-Cholesterol: Potential Therapeutic Implications in Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2014; 2014: 12.
 
[33]  de Jesus Soares T, Volpini RA, Francescato HD, Costa RS, da Silva CG, Coimbra TM. Effects of resveratrol on glycerol-induced renal injury. Life Sci. 2007; 81(8): 647-56.
 
[34]  Ruiz-Canela M, Zazpe I, Shivappa N, Hebert JR, Sanchez-Tainta A, Corella D, et al. Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvencion con DIeta MEDiterranea) trial. The British journal of nutrition. 2015; 113(6): 984-95.
 
[35]  Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutrition research reviews. 2008; 21(2): 117-33.
 
[36]  Feldman M SS. Is CRP, like ESR, Age and Gender Dependent?. Rheumatology (Sunnyvale). 2014; 4(2): 1-4.
 
[37]  Williams MJA, Williams SM, Poulton R. Breast feeding is related to C reactive protein concentration in adult women. Journal of Epidemiology and Community Health. 2006; 60(2): 146-8.
 
[38]  Roszkowska R, Taranta-Janusz K, Tenderenda-Banasiuk E, Wasilewska A. The effects of breastfeeding on serum asymmetric dimethylarginine levels and body composition in children. Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine. 2015; 10(1): 38-44.
 
[39]  Ovaskainen ML, Torronen R, Koponen JM, Sinkko H, Hellstrom J, Reinivuo H, et al. Dietary intake and major food sources of polyphenols in Finnish adults. The Journal of Nutrition. 2008; 138(3): 562-6.
 
[40]  Zujko ME, Witkowska AM, Waskiewicz A, Sygnowska E. Estimation of dietaryvintake and patterns of polyphenol consumption in Polish adult population. Advances in medical sciences. 2012; 57(2): 375-84.
 
[41]  Wang Y, Chung SJ, Song WO, Chun OK. Estimation of daily proanthocyanidin intake and major food sources in the U.S. diet. The Journal of Nutrition. 2011; 141(3): 447-52.
 
[42]  Ogce F, Ceber E, Ekti R, Oran NT. Comparison of mediterranean, Western and Japanese diets and some recommendations. Asian Pacific journal of cancer prevention: APJCP. 2008; 9(2): 351-6.
 
[43]  Bohn T. Dietary factors affecting polyphenol bioavailability. Nutrition reviews. 2014; 72(7): 429-52.
 
[44]  Scoditti E, Calabriso N, Massaro M, Pellegrino M, Storelli C, Martines G, et al. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. Archives of Biochemistry and Biophysics. 2012; 527(2): 81-9.
 
[45]  Wirth MD, Shivappa N, Steck SE, Hurley TG, Hebert JR. The dietary inflammatory index is associated with colorectal cancer in the National Institutes of Health-American Association of Retired Persons Diet and Health Study. The British journal of nutrition. 2015; 113(11): 1819-27.
 
[46]  Wirth MD, Hébert JR, Shivappa N, Hand GA, Hurley TG, Drenowatz C, et al. Anti-inflammatory Dietary Inflammatory Index scores are associated with healthier scores on other dietary indices. Nutrition Research. 36(3): 214-9.
 
[47]  Callahan E. Changes in weight loss and lipid profiles after a dietary purification program: a prospective case series. Journal of Chiropractic Medicine. 2013; 12(1): 30-8.
 
[48]  Shivappa N, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, et al. A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Public health nutrition. 2014; 17(8): 1825-33.
 
[49]  Navab M, Berliner JA, Subbanagounder G, Hama S, Lusis AJ, Castellani LW, et al. HDL and the inflammatory response induced by LDL-derived oxidized phospholipids. Arteriosclerosis, thrombosis, and vascular biology. 2001; 21(4): 481-8.
 
[50]  Wirth MD, Burch J, Shivappa N, Violanti JM, Burchfiel CM, Fekedulegn D, et al. Association of a dietary inflammatory index with inflammatory indices and metabolic syndrome among police officers. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 2014; 56(9): 986-9.
 
[51]  Chun OK, Chung S-J, Claycombe KJ, Song WO. Serum C-Reactive Protein Concentrations Are Inversely Associated with Dietary Flavonoid Intake in U.S. Adults. The Journal of Nutrition. 2008; 138(4): 753-60.
 
[52]  De Bacquer D, Clays E, Delanghe J, De Backer G. Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation. Atherosclerosis. 2006; 189(2): 428-35.
 
[53]  Gao X, Bermudez OI, Tucker KL. Plasma C-reactive protein and homocysteine concentrations are related to frequent fruit and vegetable intake in Hispanic and non- Hispanic white elders. The Journal of Nutrition. 2004; 134(4): 913-8.
 
[54]  Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, et al. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free radical biology & medicine. 2005; 38(4): 499-506.
 
[55]  Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. The American journal of clinical nutrition. 2006; 84(6): 1489-97.
 
[56]  Steptoe A, Gibson EL, Vuononvirta R, Hamer M, Wardle J, Rycroft JA, et al. The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial. Atherosclerosis. 2007; 193(2): 277-82.
 
[57]  Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Current opinion in lipidology. 2002; 13(1): 3-9.