Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2018, 6(2), 103-109
DOI: 10.12691/jfnr-6-2-6
Open AccessArticle

Anti-Obesity Effect of Proanthocyanidins from the Coat of Scarlet Runner Beans on High-Fat Diet-Fed Mice

Zhaohong Ci1, 2, Chengyu Jiang1, 2, Shuo Feng1, 2, Shan Wu1, 2, Yang Cui1, Yuki Sasaki1 and Michiyuki Kojima2, 3,

1Department of Food Production Science, Obihiro University of Agriculture and Veterinary Medicine, 11, Nishi-2-sen, Inada-machi, Obihiro, Hokkaido 080-8555, Japan

2United Graduate School of Agricultural Sciences, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550, Japan

3Department of Human Sciences, Obihiro University of Agriculture and Veterinary Medicine, 11, Nishi-2-sen, Inada-machi, Obihiro, Hokkaido 080-8555, Japan

Pub. Date: February 26, 2018

Cite this paper:
Zhaohong Ci, Chengyu Jiang, Shuo Feng, Shan Wu, Yang Cui, Yuki Sasaki and Michiyuki Kojima. Anti-Obesity Effect of Proanthocyanidins from the Coat of Scarlet Runner Beans on High-Fat Diet-Fed Mice. Journal of Food and Nutrition Research. 2018; 6(2):103-109. doi: 10.12691/jfnr-6-2-6

Abstract

Proanthocyanidins are oligomeric or polymeric flavonoids found in several plants. They can be classified into two subgroups, namely A- and B-type proanthocyanidins. The coat of scarlet runner beans contains abundant proanthocyanidins (SRPAs) of the B-type configuration. To evaluate the efficacy of SRPAs as anti-obesity agents, we first examined their effect on lipase activity in vitro and found that they are potent inhibitors of this enzyme. Subsequently, we examined their effect on mice fed a high-fat diet. Male mice were assigned to the following seven-subject dietary groups: (1) high-fat diet; (2) high-fat diet supplemented with 0.5% SRPAs; (3) high-fat diet supplemented with 1.0% SRPAs, and; (4) standard chow for 15 weeks. SRPA supplementation decreased body weight gain; liver and kidney weight; perirenal, peritesticular, and periintestinal fat content; liver cholesterol level, and; serum neutral lipid and cholesterol levels. In contrast, the faecal lipid content and the liver anti-oxidative capacity increased. These findings suggest a potential use of SRPAs as a dietary supplement exerting anti-obesity effects through the inhibition of fat digestive enzymes.

Keywords:
scarlet runner bean coat anti-obesity proanthocyanidin lipase activity inhibition fat digestion

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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