Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2017, 5(12), 914-924
DOI: 10.12691/jfnr-5-12-6
Open AccessArticle

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Abraham Escobedo-Moratilla1, Aida J. Velarde-Salcedo1, Cynthia V. Magaña-Hernández1, Alberto Barrera-Pacheco1, Eduardo Espitia-Rangel2, Alfredo Herrera-Estrella3 and Ana P. Barba de la Rosa1,

1IPICYT, Instituto Potosino de Investigación Científica y Tecnológica A.C. Camino a la Presa San José 2055, Col. Lomas 4ª Sección, C.P. 78216, San Luis Potosí, Mexico

2INIFAP, Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias. Campo Experimental Valle de México, Km 13.5 Carr Los Reyes-Texcoco,C.P. 56250 Texcoco Estado de México

3Laboratorio Nacional de Genómica para la Biodiversidad, CINVESTAV-Irapuato, Irapuato, 36821, México

Pub. Date: December 02, 2017

Cite this paper:
Abraham Escobedo-Moratilla, Aida J. Velarde-Salcedo, Cynthia V. Magaña-Hernández, Alberto Barrera-Pacheco, Eduardo Espitia-Rangel, Alfredo Herrera-Estrella and Ana P. Barba de la Rosa. Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model. Journal of Food and Nutrition Research. 2017; 5(12):914-924. doi: 10.12691/jfnr-5-12-6


Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of Tnf-α and Res, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (Lep, Fasn, Lpl) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect.

amaranth cytokines insulin resistance obesity protein isolate soybean

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