Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2017, 5(11), 859-866
DOI: 10.12691/jfnr-5-11-10
Open AccessArticle

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chung-Hsi Chou1, 2, Hui-Wen Lin3, 4, Yi-Hsieng Samuel Wu5, Yi-Ling Lin5, Chia-Chun Chiang6, Shih-Guei Fu7, and Yi-Chen Chen5,

1School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan

2Zoonoses Research Center, National Taiwan University, Taipei City, Taiwan

3Department of Optometry, Asia University, Taichung, Taiwan

4Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

5Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan

6Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi County, Taiwan

7Department of Applied Life Science and Health, Chia Nan University of Pharmacy & Science, Tainan, Taiwan

Pub. Date: November 18, 2017

Cite this paper:
Chung-Hsi Chou, Hui-Wen Lin, Yi-Hsieng Samuel Wu, Yi-Ling Lin, Chia-Chun Chiang, Shih-Guei Fu and Yi-Chen Chen. Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice. Journal of Food and Nutrition Research. 2017; 5(11):859-866. doi: 10.12691/jfnr-5-11-10


Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

anti-inflammation high-fat diet lipid-lowering effect liver Ophiocordyceps sinensis mycelium

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