Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2017, 5(7), 451-457
DOI: 10.12691/jfnr-5-7-1
Open AccessArticle

Rice Cookie Decreases Plasma and Hepatic Lipid Levels in High-Fat Diet-fed Mice: A Comparison Study with Traditional Western Style Cookies

Sun Hee Hong1, Mijeong Kim1, Minji Woo1 and Yeong Ok Song1,

1Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea

Pub. Date: June 08, 2017

Cite this paper:
Sun Hee Hong, Mijeong Kim, Minji Woo and Yeong Ok Song. Rice Cookie Decreases Plasma and Hepatic Lipid Levels in High-Fat Diet-fed Mice: A Comparison Study with Traditional Western Style Cookies. Journal of Food and Nutrition Research. 2017; 5(7):451-457. doi: 10.12691/jfnr-5-7-1


The lipid-lowering and antioxidant effects of the traditional Korean rice cookie (KRC), dasik, were compared with those of a western style cookie (WSC) in mice fed a high-fat diet (HFD). The KRC or WSC was supplemented to the HFD as 7% of the total calories. The experimental groups (n = 7) were the normal diet group, HFD group, HFD-KRC group, and HFD-WSC group. The plasma and hepatic triglyceride concentrations of the HFD-KRC group were found to be lower than those of the HFD-WSC group as a result of sterol regulatory element-binding protein 1 and fatty acid synthase expression downregulation, and concomitant peroxisome proliferator-activated receptor-alpha, carnitine palmitoyltransferase 1, and acyl-coenzyme A oxidase 1 expression upregulation (p<0.05). The hepatic reactive oxygen species and peroxynitrite levels were also diminished in the HFD-KRC group of mice, whereas their catalase and glutathione peroxidase protein expression levels were higher than those in the HFD and HFD-WSC groups (p<0.05). In conclusion, the lipid-lowering effects and antioxidant property of the KRC were greater than those of the WSC in mice fed a HFD. Thus, the choice of KRCs as a snack would be preferable to choosing WSCs.

rice cookie high-fat diet lipid antioxidant transcription factor

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[1]  Piernas, C., Popkin, and B.M., “Trends in snacking among U.S. children”, Health affairs, 29 (3). 398-404. 2010.
[2]  Karklina, D., Gedrovica, I., Reca, M., and Kronberga, M., “Production of biscuits with higher nutritional value”, Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences, 66 (3). 113-116. 2012.
[3]  Bouchard-Mercier, A., Paradis, A.M., Godin, G., Lamarche, B., Perusse, L., and Vohl, M.C., “Associations between dietary patterns and LDL peak particle diameter: A cross-sectional study”, Journal of the American College of Nutrition, 29 (6). 630-637. 2010.
[4]  Choi, W.H., Gwon, S.Y., Ahn, J., Jung, C.H., and Ha, T.Y., “Cooked rice prevents hyperlipidemia in hamsters fed a high-fat/cholesterol diet by the regulation of the expression of hepatic genes involved in lipid metabolism”, Nutrition Research, 33 (7). 572-579. 2013.
[5]  Jenkins, D.J., Kendall, C.W., Augustin, L.S., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A.l., and Axelsen, M., “Glycemic index: overview of implications in health and disease”, The American journal of clinical nutrition, 76 (1). 266S-273S. 2002.
[6]  Parks, E.J., Skokan, L.E., Timlin, M.T., and Dingfelder, C.S., “Dietary sugars stimulate fatty acid synthesis in adults”, The Journal of nutrition, 138 (6). 1039-1046. 2008.
[7]  Yaghoobi, N., Al-Waili, N., Ghayour-Mobarhan, M., Parizadeh, S.M.R., Abasalti, Z., Yaghoobi, Z., Yaghoobi, F., Esmaeili, H., Kazemi-Bajestani, S.M.R., Aghasizadeh, R., Saloom, K.Y., and Ferns, G.A.A., “Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose”, The scientific world journal, 8. 463-469. 2008.
[8]  Tang, J.J., Li, J.G., Qi, W., Qiu, W.W., Li, P.S., Li, B.L., and Song, B.L., “Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques”, Cell metabolism, 13 (1). 44-56. 2011.
[9]  Goldstein, J.L., DeBose-Boyd, R.A., and Brown, M.S., “Protein sensors for membrane sterols”, Cell, 124 (1). 35-46. 2006.
[10]  Yang, J., Goldstein, J.L., Hammer, R.E., Moon, Y.A., Brown, M.S., and Horton, J.D., “Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene”, Proceedings of the National Academy of Sciences, 98 (24). 13607-13612. 2001.
[11]  Ji, G., Zhao, X., Leng, L., Liu, P., and Jiang, Z., “Comparison of dietary control and atorvastatin on high fat diet induced hepatic steatosis and hyperlipidemia in rats”, Lipids in health and disease, 10 (1). 23-10. 2011.
[12]  Cao, Y., Bei, W., Hu, Y., Cao, L., Huang, L., Wang, L., Luo, D., Chen, Y., Yao, X., He, W., Liu, X., and Guo, J., “Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats”, Phytomedicine, 19 (8). 686-692. 2012.
[13]  Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S., and Kalayci, O., “Oxidative stress and antioxidant defense”, World Allergy Organization Journal, 5 (1). 9-19. 2012.
[14]  Willcox, J.K., Ash, S.L., and Catignani, G.L., “Antioxidants and prevention of chronic disease”, Critical reviews in food science and nutrition, 44 (4). 275-295. 2004.
[15]  Bowen, P.E. and Borthakur, G., “Postprandial lipid oxidation and cardiovascular disease risk”, Current atherosclerosis reports, 6 (6). 477-484. 2004.
[16]  Bae, J.H., Bassenge, E., Kim, K.B., Kim, Y.N., Kim, K.S., Lee, H.J., Moon, K.C., Lee, M.S., Park, K.Y., and Schwemmer, M., “Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress”, Atherosclerosis, 155 (2). 517-523. 2001.
[17]  Tsai, W.C., Li, Y.H., Lin, C.C., Chao, T.H., and Chen, J.H., “Effects of oxidative stress on endothelial function after a high-fat meal”, Clinical Science, 106 (3). 315-319. 2004.
[18]  Folch, J., Lees, M., and Sloane-Stanley G.H., “A simple method for the isolation and purification of total lipids from animal tissues”, The Journal of Biological Chemistry, 226 (1). 497-509. 1957.
[19]  Ohkawa, H., Ohishi, N., and Yagi, K.., “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction”, Analytical biochemistry, 95 (2). 351-358. 1979.
[20]  Ellman, M.A., “A colorimetric method for determining low concentrations of mercaptans”, Archives of biochemistry and Biophysics, 74 (2). 443-450. 1958.
[21]  Kooy, N.W., Royall, J.A., Ischiropoulos, H., and Beckman, J.S., “Peroxynitrite-mediated oxidation of dihydrorhodamine 123”, Free Radical Biology and Medicine, 16 (2). 149-156. 1994.
[22]  Jung, K., Hong, S.H., Kim, M., Han, J.S., Jang, M.S., and Song, Y.O., “Antiatherogenic effects of Korean cabbage kimchi with added short arm octopus”, Food Science and Biotechnology, 24 (1). 249-255. 2015.
[23]  Longo, K.A., Wright, W.S., Kang, S., and Gerin, I., Chiang S.H., Lucas, P.C., Opp, M.R., and MacDougald, O.A., “Wnt10b inhibits development of white and brown adipose tissues”, Journal of Biological Chemistry, 279 (34). 35503-35509. 2004.
[24]  Elmquist, J.K., Coppari, R., Balthasar, N., Ichinose, M., and Lowell, B.B., “Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis”, Journal of Comparative Neurology, 493 (1). 63-71. 2005.
[25]  Ahima, R.S., “Digging deeper into obesity”, The Journal of clinical investigation, 121 (6). 2076-2079. 2011.
[26]  Yang, X.R., Wat, E., Wang, Y.P., Ko, C.H., Koon, C.M., Siu, W.S., Gao, S., Cheung, D.W.S., Lau, C.B.S., Ye, C.X., and Leung, P.C., “Effect of dietary cocoa tea (Camellia ptilophylla) supplementation on high-fat diet-induced obesity, hepatic steatosis, and hyperlipidemia in mice”, Evidence-Based Complementary and Alternative Medicine, 2013. 1-11. 2013.
[27]  Al-Waili, N.S., “Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose”, Journal of medicinal food, 7 (1). 100-107. 2004.
[28]  Parks, E.J., Skokan, L.E., Timlin, M.T., and Dingfelder, C.S., “Dietary sugars stimulate fatty acid synthesis in adults”, The Journal of nutrition, 138 (6). 1039-1046. 2008.
[29]  Pessayre, D., Mansouri, A., and Fromenty, B., “Nonalcoholic Steatosis and Steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis”, American Journal of Physiology-Gastrointestinal and Liver Physiology, 282 (2). G193-G199. 2002.
[30]  Kilicoglu, B., Gencay, C., Kismet, K., Kilicoglu S.S., Erguder, I., Erel, S., Sunay, A.E., Erdemli, E., Durak, I., and Akkus, M.A., The ultrastructural research of liver in experimental obstructive jaundice and effect of honey. The American Journal of Surgery, 195 (2). 249-256. 2008.
[31]  Wang, S.Y. and Gao, H., “Effect of chitosan-based edible coating on antioxidants, antioxidant enzyme system, and postharvest fruit quality of strawberries (Fragaria x aranassa Duch.)”, LWT-Food Science and Technology, 52 (2). 71-79. 2013.
[32]  Yao, L.K., Razak, S.L.A., Ismail, N., Fai, N.C., Asgar, M.H.A.M., Sharif, N.M., Aan, G.J., and Jubri, Z., “Malaysian gelam honey reduces oxidative damage and modulates antioxidant enzyme activities in young and middle aged rats”, Journal of Medicinal Plants Research, 5 (23). 5618-5625. 2011.
[33]  Petrus, K., Schwartz, H., and Sontag, G., Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry. Analytical and bioanalytical chemistry, 400 (8). 2555-2563. 2011.