Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(4), 243-252
DOI: 10.12691/jfnr-5-4-6
Open AccessArticle

Effect of Ingredients on Non-enzymatic Browning, Nutritional Value and Furanic Compounds in Spanish Infant Formulas

José Contreras-Calderón1, , Eduardo Guerra-Hernández2, Belén García-Villanova2, Faver Gómez-Narváez3 and Andrés Zapata-Betancur3

1Bioali Research Group, Food Department, Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Calle street 67 No. 53 – 108, City University, Medellín, Colombia

2Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18012 Granada, Spain

3Bioali Research Group, Food Department, Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Calle street 67 No. 53 – 108, City University, Medellín, Colombia.

Pub. Date: April 11, 2017

Cite this paper:
José Contreras-Calderón, Eduardo Guerra-Hernández, Belén García-Villanova, Faver Gómez-Narváez and Andrés Zapata-Betancur. Effect of Ingredients on Non-enzymatic Browning, Nutritional Value and Furanic Compounds in Spanish Infant Formulas. Journal of Food and Nutrition Research. 2017; 5(4):243-252. doi: 10.12691/jfnr-5-4-6

Abstract

During their processing, the infant formulas (IFs) are subjected to different thermal processes, which affect their safety and nutritional value, being influenced by the quality and type of ingredients used. The objective of this study was to evaluate the effect of ingredients used in commercial powdered IFs on furosine, HMF, furfural, available lysine content and evaluation of possible toxic effect of furanic compounds. Principal components (PC) and cluster analysis (CA) were employed to investigate relationships among IFs and indicators. Two PC were obtained which explain 77.3% of the total variance, grouping the IFs in five clusters. Significant higher values of available lysine were obtained in IFs with whey milk or skimmed milk; likewise, furosine was obtained in IFs with lactose, whey milk, milk proteins, skimmed milk or partially hydrolyzed whey (PHW). Significant higher values of HMF and furfural were obtained in IFs with starch. The maximum free furanic compounds provided by IFs were of 1.7 mg/person/day. HMF content does not represent a risk to the babies’ health. All IFs except one cover more than 90% of available lysine needs for a 3-month aged baby. PC and CA are useful to evaluate heat damage in IFs.

Keywords:
infant formulas furosine HMF furfural available lysine toxic effect principal components analysis

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References:

[1]  Parker, J. K., “The kinetics of thermal generation of flavour,” Journal of the Science of Food and Agriculture, 93 (2), 197-208, January 2013.
 
[2]  Contreras-Calderón, J., Guerra-Hernández, E., and García-Villanova, B., “Utility of some indicators related to the Maillard browning reaction during processing of infant formulas,” Food Chemistry, 114 (4), 1265-1270, June 2009.
 
[3]  Palombo, R., Gertler, A., and Saguy, I., “A Simplified Method for Determination of Browning in Dairy Powders,” Journal of Food Science, 49 (6), 1609-1609, November 1984.
 
[4]  Laguerre, J. C., Pascale, G. W., David, M., Evelyne, O., Lamia, A. A., and Inès, B. A., “The impact of microwave heating of infant formula model on neo-formed contaminant formation, nutrient degradation and spore destruction,” Journal of Food Engineering, 107 (2), 208-213, December 2011.
 
[5]  Van Lancker, F., Adams, A., and De Kimpe, N., “Chemical Modifications of Peptides and Their Impact on Food Properties,” Chemical Reviews, 111 (12), 7876-7903, December 2011.
 
[6]  Mesías, M., Seiquer, I., and Navarro, M. P., “Consumption of highly processed foods: Effects on bioavailability and status of zinc and copper in adolescents,” Food Research International, 45 (1), 184-190, January 2012.
 
[7]  Contreras-Calderón, J., Guerra-Hernández, E., and García-Villanova, B., “Indicators of non-enzymatic browning in the evaluation of heat damage of ingredient proteins used in manufactured infant formulas,” European Food Research and Technology, 227 (1), 117-124, July 2008.
 
[8]  Delgado-Andrade, C. and Rufián-Henares, J. ., Eds., Assessing the generation and bioactivity of neo-formed compounds in thermally treated foods, Atrio S.L., Granada, 2009.
 
[9]  Ferrer, E., Alegría, A., Farré, R., Abellán, P., and Romero, F., “High-performance liquid chromatographic determination of furfural compounds in infant formulas during full shelf-life,” Food Chemistry, 89 (4), 639-645, 2005.
 
[10]  Chávez-Servín, J., Castellote, A., and López-Sabater, C., “Evolution of potential and free furfural compounds in milk-based infant formula during storage,” Food Research International, 39 (5), 536-543, 2006.
 
[11]  Rufían-Henares, J. a and de la Cueva, S. P., “Assessment of hydroxymethylfurfural intake in the Spanish diet.,” Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25 (11), 1306-1312, 2008.
 
[12]  Ferrer, E., Alegría, A., Farré, R., Abellán, P., Romero, F., and Clemente, G., “Evolution of available lysine and furosine contents in milk-based infant formulas throughout the shelf-life storage period,” Journal of the Science of Food and Agriculture, 83 (5), 465-472, April 2003.
 
[13]  Guerra-Hernandez, E., Leon, C., Corzo, N., Garcia-Villanova, B., and Romera, J., “Chemical changes in powdered infant formulas during storage,” International Journal of Dairy Technology, 55 (4), 171-176, 2002.
 
[14]  Abellán, P., Farré, R., Alegría-Torán, A., Ferrer, E., and Romero, F., “Indicadores de deterioro de la calidad proteica y valor nutritivo de la leche,” Food science and technology international, 5 (6), 447-461, 1999.
 
[15]  Rufián-Henares, J. Á., García-Villanova, B., and Guerra-Hernández, E., “Generation of furosine and color in infant/enteral formula-resembling systems,” Journal of Agricultural and Food Chemistry, 52 (17), 5354-5358, August 2004.
 
[16]  Burri, J., Bertoli, C., and Stadler, R. H., “Food Processing and Nutritional Aspects,” in Process-Induced Food Toxicants, R. Stadler and D. Lineback, Eds. John Wiley & Sons, Inc., Hoboken, NJ, USA, 2008, 645-677.
 
[17]  Viegas, O., Novo, P., Pinto, E., Pinho, O., and Ferreira, I. M. P. L. V. O., “Effect of charcoal types and grilling conditions on formation of heterocyclic aromatic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs) in grilled muscle foods,” Food and Chemical Toxicology, 50 (6), 2128-2134, June 2012.
 
[18]  Lineback, D. R. and Stadler, R. H., “Introduction to Food Process Toxicants,” in Process-Induced Food Toxicants, D. R. Lineback and R. H. Stadler, Eds. John Wiley & Sons, Inc., Hoboken, NJ, USA, 2008, 3-19.
 
[19]  Petisca, C., “Furanic compounds in food products: Assessment and mitigation strategies,” University of Porto, 2013.
 
[20]  Abraham, K., Gürtler, R., Berg, K., Heinemeyer, G., Lampen, A., and Appel, K. E., “Toxicology and risk assessment of 5-Hydroxymethylfurfural in food,” Molecular Nutrition & Food Research, 55 (5), 667-678, May 2011.
 
[21]  Resmini, P., Pellegrino, L., and Battelli, G., “Accurate quantification of furosine in milk and dairy products by a direct HPLC method,” Italian Journal of Food Science, 3, 173-183, 1990.
 
[22]  Gökmen, V. and Morales, F. J., “Hydroxy-methylfurfural,” Encyclopedia of food safety, 2, 404-408.
 
[23]  Morales, F. J. and Jiménez-Pérez, S., “Hydroxymethylfurfural determination in infant milk-based formulas by micellar electrokinetic capillary chromatography,” Food Chemistry, 72 (4), 525-531, March 2001.
 
[24]  Fernández-Artigas, P., Guerra-Hernández, E., and García-Villanova, B., “Browning indicators in model systems and baby cereals.,” Journal of agricultural and food chemistry, 47, 2872-2878, 1999.
 
[25]  Rufián-Henares, J. A., Delgado-Andrade, C., and Morales, F. J., “Application of a fast high-performance liquid chromatography method for simultaneous determination of furanic compounds and glucosylisomaltol in breakfast cereals.,” Journal of AOAC International, 89 (1), 161-165.
 
[26]  Albalá-Hurtado, S., Veciana-Nogués, M. T., Mariné-Font, A., and Vidal-Carou, M. C., “Changes in Furfural Compounds during Storage of Infant Milks,” Journal of Agricultural and Food Chemistry, 46, 2998-3003, 1998.
 
[27]  Ferrer, E., Alegría, A., Farré, R., Abellán, P., and Romero, F., “Effects of Thermal Processing and Storage on Available Lysine and Furfural Compounds Contents of Infant Formulas,” Journal of Agricultural and Food Chemistry, 48 (5), 1817-1822, May 2000.
 
[28]  Chávez-Servín, J. L., Castellote, A. I., and López-Sabater, M. C., “Evolution of potential and free furfural compounds in milk-based infant formula during storage,” Food Research International, 39, 536-543, 2006.
 
[29]  Albalá-Hurtado, S., Veciana-Nogués, M. T., Mariné-Font, A., and Vidal-Carou, M. C., “Progress of Browning Reactions during Storage of Liquid Infant Milks,” Journal of Agricultural and Food Chemistry, 47 (10), 4033-4037, October 1999.
 
[30]  Janzowski, C., Glaab, V., Samimi, E., Schlatter, J., and Eisenbrand, G., “5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione,” Food and Chemical Toxicology, 38 (9), 801-809, 2000.
 
[31]  Anese, M. and Suman, M., “Mitigation strategies of furan and 5-hydroxymethylfurfural in food,” Food Research International, 51 (1), 257-264, 2013.
 
[32]  EFSA, “Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to flavouring group evaluation 13: furfuryl and furan derivatives with and without additional,” EFSA Journal, 215, 1-73, 2005.
 
[33]  JECFA, “Toxicological evaluation of certain food additives,” in The forty-fourth meeting of the Joint FAO/WHO ExpertCommittee on Food Additives and Contaminants, 1996.
 
[34]  Zaitzev, A. N., Simonyan, T. A., and Pozdnyakov, A. L., “Hygienic standardization of oxymethylfurfurol in food products,” Voprosy pitaniia, 1, 52-55, 1975.
 
[35]  Chávez-Servín, J. L., De La Torre Carbot, K., García-Gasca, T., Castellote, A. I., and López-Sabater, M. C., “Content and evolution of potential furfural compounds in commercial milk-based infant formula powder after opening the packet,” Food Chemistry, 166, 486-491, 2015.
 
[36]  World Health Organization, “The WHO Child Growth Standards,” 2006. [Online]. Available: http://www.who.int/childgrowth/standards/en/. [Accessed: 15-Sep-2016].
 
[37]  Rufián-Henares, J. A. and Delgado-Andrade, C., “Effect of digestive process on Maillard reaction indexes and antioxidant properties of breakfast cereals,” Food Research International, 42 (3), 394-400, 2009.
 
[38]  Delgado-Andrade, C., Rufián-Henares, J. A., and Morales, F. J., “Fast method to determine furosine in breakfast cereals by capillary zone electrophoresis,” European Food Research and Technology, 221 (5), 707-711, October 2005.
 
[39]  Morales, V., Olano, A., and Corzo, N., “Ratio of Maltose to Maltulose and Furosine as Quality Parameters for Infant Formula,” Journal of Agricultural and Food Chemistry, 52 (22), 6732-6736, November 2004.
 
[40]  Fenaille, F., Parisod, V., Visani, P., Populaire, S., Tabet, J.-C., and Guy, P. A., “Modifications of milk constituents during processing: A preliminary benchmarking study,” International Dairy Journal, 16 (7), 728-739, 2006.
 
[41]  Penndorf, I., Biedermann, D., Maurer, S. V., and Henle, T., “Studies on N-Terminal Glycation of Peptides in Hypoallergenic Infant Formulas: Quantification of α- N -(2-Furoylmethyl) Amino Acids,” Journal of Agricultural and Food Chemistry, 55 (3), 723-727, February 2007.
 
[42]  Baptista, J. A. . and Carvalho, R. C. ., “Indirect determination of Amadori compounds in milk-based products by HPLC/ELSD/UV as an index of protein deterioration,” Food Research International, 37 (8), 739-747, 2004.
 
[43]  Damjanovic Desic, S. and Birlouez-Aragon, I., “The FAST index – A highly sensitive indicator of the heat impact on infant formula model,” Food Chemistry, 124 (3), 1043-1049, 2011.
 
[44]  Rufián Henares, J., Guerra Hernández, E., and García Villanova, B., “Evolución de compuestos furánicos durante el procesado y conservación de fórmulas enterales.,” Revista de tecnología e higiene de los alimentos, 324, 23-28, 2001.
 
[45]  Chávez-Servín, J. L., Castellote, A. I., and López-Sabater, M. C., “Analysis of potential and free furfural compounds in milk-based formulae by high-performance liquid chromatography: Evolution during storage,” Journal of Chromatography A, 1076 (1-2), 133-140, 2005.
 
[46]  Pereyra-Gonzáles, A. S., Naranjo, G. B., Malec, L. S., and Vigo, M. S., “Available lysine, protein digestibility and lactulose in commercial infant formulas,” International Dairy Journal, 13 (2), 95-99, 2003.
 
[47]  DRIs, Dietary reference intakes for Energy, Carbohydrates, Fiber, Fat, Protein and Amino Acids (macronutrients), USA, 2002.
 
[48]  Contreras-Calderón, J., Guerra-Hernández, E., and García-Villanova, B., “Modification of nutritional value during storage of infant formulas elaborated with different intact and partially hydrolyzed proteins and carbohydrates,” VITAE, 22, 87-100, 2015.
 
[49]  Chávez-Servín, J. L., Castellone, A. I., and López-Sabater, M. C., “Evolution of available lysine and lactose contents in supplemented microencapsulated fish oil infant formula powder during storage,” International Journal of Food Science & Technology, 43, 1121-1128, 2008.
 
[50]  Evangelisti, F., Calcagno, C., Nardi, S., and Zunin, P., “Deterioration of protein fraction by Maillard reaction in dietetic milks,” Journal of Dairy Research, 66, 237-243, 1999.
 
[51]  Pischetsrieder, M. and Henle, T., “Glycation products in infant formulas: chemical, analytical and physiological aspects,” Amino Acids, 42, 1111-1118, 2012.
 
[52]  Eskin, M., Ho, C.-T., and Shahidi, F., “Browning reaction in food,” in Biochemestry of foods, Elsevier, Ed. 2013, 245-290.
 
[53]  Erbersdobler, H. F., Dehn, B., Nangpal, A., and Reuter, H., “Determination of furosine in heated milk as a measure of heat intensity during processing,” Journal of Dairy Research, 54, 147-151, 1987.
 
[54]  Birlouez-Aragon, I. et al., “Assessment of protein glycation markers in infant formulas,” Food Chemistry, 87, 253-259, 2004.
 
[55]  Capuano, E., Ferrigno, A., Acampa, I., Ait-Ameur, L., and Fogliano, V., “Characterization of the Maillard reaction in bread crisps,” European Food Research and Technology, 228, 311-319, 2008.