Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(2), 110-115
DOI: 10.12691/jfnr-5-2-6
Open AccessArticle

The Health Benefits of Jeju Gamgyul (Citrus unshiu Marc.) Brandy and Wine

Shin Young Park1 and Sun Joo Lee2,

1Department of Clinical Pathology, Cheju Halla University, Jeju 690-708, Korea

2Department of Chemistry, Jeju National University, Jeju 690-756, Korea

Pub. Date: February 18, 2017

Cite this paper:
Shin Young Park and Sun Joo Lee. The Health Benefits of Jeju Gamgyul (Citrus unshiu Marc.) Brandy and Wine. Journal of Food and Nutrition Research. 2017; 5(2):110-115. doi: 10.12691/jfnr-5-2-6

Abstract

Beneficial health effects of fruits and vegetables in the diet have been attributed to the reduction of risk for some diseases, such as diabetes, chronic diseases, cancer, or cardiovascular diseases. Citrus and its peels have been used in Asian folk medicine due to abundant flavonoids and the fact that their pulp are usually consumed like juice or jam, although their functional effects are much higher than those of fruit peels. This investigation inquired into the effects of Gamgyul wine, which is derived from whole fruits of Citrus unshiu, with respect to antioxidant property, anti-diabetic activity, low density lipoprotein (LDL) oxidative inhibition and flavanones. In particular, antioxidant and antidiabetic activities of both Gamgyul wine and brandy were measured. However, the differences of the antioxidant and antidiabetic effects of Gamgyul wine were trifling between dynamite and microfiltration processes. In particular, the effect of antidiabetic activity was rather significant as demonstrated in the Gamgyul brandy. The results showed that α-glucosidase inhibition rates at 20 µL/mL for Gamgyul brandy and wine were 50% and 20%, respectively. Almost 100% inhibition rate was shown at 80 µL/mL treatment for all the samples. Antioxidant activities and LDL oxidative inhibition were also measured. Gamgyul wine showed increased concentration-dependent antioxidant activities, while epigallocatechin gallate (EGCG) revealed an almost same level of activities. On the other hand, Gamgyul brandy presented little activity at any treatment concentration. Gamgyul wine in 20 µL/mL inhibited LDL oxidation approximately three times more than that of the comparative negative control, D.W. Flavanone analysis showed detections of both narirutin and hesperidin, while narirutin was the most abundant flavanone in Gamgyul wine. These overall results suggest that Gamgyul wine has the potential to be used as a functional dietary supplement and is an effective α-glucosidase inhibitor, which may be beneficial only for low to moderate intake.

Keywords:
LDL oxidative inhibition α-glucosidase inhibitor Citrus unshiu Marc. antioxidant Gamgyul wine brandy

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References:

[1]  United Nations, 2009. World population ageing 2009. http://www.un.org/esa/population/publications/WPA2009/WPA2009_WorkingPaper.
 
[2]  Finkelstein E.,French S.,Variyam J.N.,Haines P.S., “Pros and cons of proposed interventions to promote healthy eating”, American Journal of Preventive Medicine, 27 (3) ((suppl)). 163-171. 2004.
 
[3]  Kim Y.K., Moon J.S., Ryu S.H., Lee J.H., Kim Y.S., “The relationship between the popular beverages in Korea and reported postprandial heartburn”, Korean Journal of Gastroenterology, 55(2). 109-118. 2010.
 
[4]  Kopp P., “Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?”, European Journal of Endocrinology, 138(6). 619-620. 1998.
 
[5]  Criqui M.M., “Do known cardiovascular risk factors mediate the effect of alcohol on cardiovascular disease?”, Novartis Foundation Symposium, 216, 159-167. discussion 167-172. 1998.
 
[6]  Goldfinger T.M., “Beyond the French paradox: the impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease”, Cardiology Clinics, 21(3). 449-457. 2003.
 
[7]  Yamada T., Hayasaka S., Shibata Y., Ojima T., Saegusa T., Gotoh T., Ishikawa S., Nakamura Y., Kayaba K., “Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study, Journal of Epidemiology, 21. 1691-175. 2011.
 
[8]  Nogata Y., Sakamoto K., Shiratsuchi H., Ishii T., Yano M., Ohta H., “Flavonoid composition of fruit tissues of citrus species”, Bioscience, Biotechnology, and Biochemistry, 70(1). 178-192. 2006.
 
[9]  Robards K, Li X, Antolovich M, Boyd S., “Characterisation of citrus by chromatographic analysis of flavonoids”, Journal of Science od Food and Agriculture, 75. 87-101. 1997.
 
[10]  Sun Y., Qiao L., Shen Y., Jiang P., Chen J., Ye X., “Phytochemical profile and antioxidant activity of physiological drop of citrus fruits”, Journal of Food Science, 78(1). C37-42. 2013.
 
[11]  Barros H.R., Ferreira T.A., Genovese M.I.. “Antioxidant capacity and mineral content of pulp and peel from commercial cultivars of citrus from Brazil”, Food Chemistry, 15, 134(4). 1892-1898. 2012.
 
[12]  Brand-Williams W., Cuvelier M.E., Berset C., “Use of free radical method to evaluate antioxidant activity”, Lebensm Wiss Technology, 28. 25-30. 1995.
 
[13]  Matsui T., Ueda T., Oki T., Sugita K., Terahara N., Matsumoto K., “alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 2. alpha-Glucosidase inhibition by isolated acylated anthocyanins”, Journal of Agricultural and Food Chemistry, 49(4). 1952-6. 2001.
 
[14]  Tanabe S., Kinuta Y., Yasumatsu H., Takayanagi M., Kobayashi S., Takido N., Sugiyama M., 2007. “Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen”, Bioscience, Biotechnology and Biochemistry, 71(11). 2852-2855. 2007.
 
[15]  Ihara H., Yamamoto H., Ida T., Tsutsuki H., Sakamoto T., Fujita T., Okada T., Kozaki S., 2012. “Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes”, Bioscience, Biotechnology and Biochemistry, 76(10). 1843-1848. 2012.
 
[16]  Yilmazer-Musa M., Griffith A.M., Michels A.J., Schneider E., Frei B.., “Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity,” Journal of Agricultural and Food Chemistry, 2,60(36). 8924-8929. 2012.
 
[17]  Forester S.C., Gu Y., Lambert J.D., “Inhibition of starch digestion by the green tea polyphenol, (-)-epigallocatechin-3-gallate,” Molecular Nutrition & Food Research, 56(11). 1647-1654. 2012.
 
[18]  Wolfram S., Raederstorff D., Preller M., Wang Y., Teixeira S.R., Riegger C., Weber P., “Epigallocatechin gallate supplementation alleviates diabetes in rodents”, Journal of Nutrition, 136(10). 2512-1518. 2006.
 
[19]  Sugiura M., Ogawa K., Yano M., “Effect of chronic administration of fruit extract (Citrus unshiu Marc.) on glucose tolerance in GK rats, a model of type 2 diabetes”, Bioscience, Biotechnology, and Biochemistry, 70(1). 293-295. 2006. .
 
[20]  Liu Y., Dong M., Yang Z., Pan S., “Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway”, International Journal of Biological Macromolecules, 89. 484-488. 2016.
 
[21]  de Sousa E., Zanatta L., Seifriz I., Creczynski-Pasa T.B., Pizzolatti M.G., Szpoganicz B., Silva F.R., “Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves”, Journal of Natural Products, 67(5). 829-832. 2004.
 
[22]  Hanamura T., Hagiwara T., Kawagishi H., “Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit”, Bioscience, Biotechnology, and Biochemistry, 69(2). 280-6. 2005.
 
[23]  Thilagam E., Parimaladevi B., Kumarappan C., Mandal S.C., “α-glucosidase and α-amylase inhibitory activity of Senna surattensis”, Journal of Acupuncture and Meridian Studies, 6(1). 24-30. 2013.
 
[24]  Ha S.K., Park H.Y., Eom H., Kim Y., Choi I., “Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation”, Food and Chemical Toxicology, 50(10). 3498-3504. 2012.
 
[25]  Song Y. W., Moon K. S., Cho S. M., “Antioxidant Activity and Nutrient Content of Ethanol and Hot-Water Extracts of Citrus unshiu Pomace”, Journal of the Korean Scoiety of Food Science and Nutrition, 42(9). 1345-1350. 2013.
 
[26]  Moura L.M., Sylos C.M., “The effect of the manufacturing process on the citrus juice on the concentrations of flavanones”, Alimentos Nutrition Araraquara, 19(3). 379-384. 2008.
 
[27]  Escudero-López B., Cerrillo I., Herrero-Martín G., Hornero-Méndez D., Gil-Izquierdo A., Medina S., Ferreres F., Berná G., Martín F., Fernández-Pachón M.S., “Fermented orange juice: source of higher carotenoid and flavanone contents”, Journal of Agricultural and Food Chemistry, 18. 61(37). 8773-8782. 2013.