Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(2), 74-79
DOI: 10.12691/jfnr-5-2-1
Open AccessArticle

Royal Jelly Supplementation Ameliorated Immune Impairment via Inhibition of Oxidative Stress in Low Micronutrient-induced Immunodeficient Mice

Han-Ol Kwon1, Minhee Lee1, Yun-Hi Cho1, Woojin Jun2 and Jeongmin Lee1, 3,

1Department of Medical Nutrition, Kyung Hee University, Yongin, South Korea

2Department of Food and Nutrition, Cheonnam National University, Gwangju, South Korea

3Research Institute of Clinical Nutrition, Kyung Hee University, Seoul, South Korea

Pub. Date: February 09, 2017

Cite this paper:
Han-Ol Kwon, Minhee Lee, Yun-Hi Cho, Woojin Jun and Jeongmin Lee. Royal Jelly Supplementation Ameliorated Immune Impairment via Inhibition of Oxidative Stress in Low Micronutrient-induced Immunodeficient Mice. Journal of Food and Nutrition Research. 2017; 5(2):74-79. doi: 10.12691/jfnr-5-2-1


The effect of royal jelly (RJ) on the survival and immune dysfunctions of C57BL/6 mice induced by low micronutrient supplementation was investigated. Female C57BL/6 mice were supplemented with 0.2% or 1% royal jelly following induction of immune deficiency by 7.5% low micronutrient intake. The administration was maintained for 16 weeks for mortality assay and 10 weeks for the immunological analysis. Supplementation of 1% RJ was found to extend the median survival time in immune deficient mice. Although dysfunction of T- and B-cell mitogenesis was observed in primary cultured splenocytes during micronutrient deficiency, 1% RJ supplementation significantly increased T- and B-cell response against mitogens. In addition, 1% RJ supplementation partially recovered the abnormal alteration in cytokine secretion, indicated by the decreased secretion of T-helper 1 cytokines and increased secretion of T-helper 2 cytokines resulting from low micronutrient levels. The hepatic vitamin E level was significantly decreased (p<0.05) following micronutrient deficiency, in accordance with the increased hepatic lipid peroxidation level. However, 1% RJ supplementation reduced hepatic lipid peroxidation, which may result from the restoration of the hepatic vitamin E level. Therefore, the present study indicated that 1% RJ supplementation may ameliorate the premature mortality in mice through the restoration of immune dysfunctions, which may result from antioxidative ability of RJ in immune deficient mice caused by low micronutrient intake.

malnutrition royal jelly antioxidant immunodeficiency cytokine

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