Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2016, 4(12), 795-798
DOI: 10.12691/jfnr-4-12-5
Open AccessArticle

The Effects of Probiotic On Serum Lipid Profiles in Patients with type 2 Diabetes Mellitus: A Randomized Clinical Trial

Tahere Tofighiyan1, Akram Kooshki2, , BiBi Leila Hoseini3 and Maryam Mohammadi4

1Department of Nursing, School of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran

2Department of Nutrition & Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

3School of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran

4Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Pub. Date: December 12, 2016

Cite this paper:
Tahere Tofighiyan, Akram Kooshki, BiBi Leila Hoseini and Maryam Mohammadi. The Effects of Probiotic On Serum Lipid Profiles in Patients with type 2 Diabetes Mellitus: A Randomized Clinical Trial. Journal of Food and Nutrition Research. 2016; 4(12):795-798. doi: 10.12691/jfnr-4-12-5

Abstract

Background & Objectives: With regard to probable mechanisms about probiotics effect in cholesterol lowering and since final conclusion about fat-lowering effect of probiotics is not clear; Present study has been conducted to determine effect of probiotics on serum lipid profile level of patients with type II diabetes mellitus. Material and Methods: This double-blind randomized, clinical trial study was done on 44 type-2 diabetic patients, by available sampling. Patients were allocated to either case or control groups by permuted block randomization. Probiotic group received one probiotic tablet and placebo group received one placebo tablet daily for 8 weeks. At baseline and the end of study, 5 ml blood was collected from each patient after a 14-h fasting in order to measure serum lipid profile. Data were analyzed by descriptive and analytic statistics. Results: Demographic parameters, anthropometric and dietary factors were not significantly different between two groups at baseline and the end of week 8. Probiotic intake caused significant decrease in serum total cholesterol (p=0.0001), LDL (p=0.001) and increase serum HDL (p=0.001) in probiotic group. Results showed that observed difference in LDL and HDL between 2 groups was not significant, but serum cholesterol had a significant difference between 2 groups. Conclusions: This study showed that probiotic supplementation is probably effective in improving risk factors for cardiovascular diseases in type 2 diabetes, via serum lipid profile reduction.

Keywords:
probiotics serum lipids diabetes mellitus type 2

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