Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2016, 4(12), 773-781
DOI: 10.12691/jfnr-4-12-2
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Health Benefits of Edible Mushrooms Focused on Coriolus versicolor: A Review

Aritson Cruz1, Lígia Pimentel1, Luis M. Rodríguez-Alcalá1, 2, Tito Fernandes3 and Manuela Pintado1,

1Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital, Apartado 2511, 4202-401 Porto, Portugal

2Centro de Investigación en Recursos Naturales y Sustentabilidad (CIRENYS), Universidad Bernardo O’Higgins, Fábrica N∘ 1990, Segundo Piso, Santiago, Chile

3CEIL, Lúrio University, Marrere, Nampula, Mozambique

Pub. Date: December 08, 2016

Cite this paper:
Aritson Cruz, Lígia Pimentel, Luis M. Rodríguez-Alcalá, Tito Fernandes and Manuela Pintado. Health Benefits of Edible Mushrooms Focused on Coriolus versicolor: A Review. Journal of Food and Nutrition Research. 2016; 4(12):773-781. doi: 10.12691/jfnr-4-12-2


The biological properties present in mushrooms have been extensively studied. Besides nutritional properties, mushrooms have attracted market attention because they are a potential source of bioactive compounds able to perform several functions in organisms with benefits for consumer health. In recent years Coriolus versicolor aroused interest among researchers because of the bioactive properties demonstrated. Polysaccharopeptide (PSP) and polysaccharopeptide Krestin (PSK) have shown to be useful adjuncts to the therapy of cancer; these polysaccharides from C. versicolor have also shown prebiotic activity, stimulating the growth of probiotic bacteria. Furthermore, enzymes such as laccases produced by Pleurotus eryngii and Ganoderma lucidium can confer activity against HIV; lectins produced by Pleurotus ostreatus and Ganoderma carpense have shown anti-proliferative activity in tumour cells; superoxide dismutase present in some mushrooms has antioxidant activity. Secondary metabolites such as terpenes, steroids, anthraquinones and benzoic acid have also antitumour activity. This review article highlights the health-promoting potential of several mushroom species with special emphasis on C. versicolor.

Polysaccharopeptide Polysaccharopeptide Krestin Health-promoting Potential Bioactive Compounds Prebiotic Activity

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[1]  Chang, S. T., “Global impact of edible and medicinal mushrooms on human welfare in the 21st century: Nongreen revolution,” International Journal of Medicinal Mushrooms, 1. 1-7. 1999.
[2]  Sánchez, C., “Modern aspects of mushroom culture technology,” Applied Microbiology and Biotechnology, 64 (6). 756-762. June 2004.
[3]  Aida, F. M. N. A., Shuhaimi, M., Yazid, M. and Maaruf, A. G., “Mushroom as a potential source of prebiotics: a review,” Trends in Food Science & Technology, 20 (11-12). 567-575. December 2009.
[4]  FAOSTAT, “FAOSTAT,” Food and Agricultural Organization of the United Nations. 2014.
[5]  Stachowiak, B. and Reguła, J., “Health-promoting potential of edible macromycetes under special consideration of polysaccharides: a review,” European Food Research and Technology, 234 (3). 369-380. January 2012.
[6]  Gunde-Cimerman, N. and Cimerman, A., “Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase–lovastatin,” Experimental Mycology, 19 (1). 1-6. March 1995.
[7]  Synytsya, A., Míčková, K., Synytsya, A., Jablonský, I., Spěváček, J., Erban, V., Kováříková, E. and Čopíková, J., “Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: structure and potential prebiotic activity,” Carbohydrate Polymers, 76 (4). 548-556. May 2009.
[8]  Trovato, A., Siracusa, R., Di Paola, R., Scuto, M., Fronte, V., Koverech, G., Luca, M., Serra, A., Toscano, M. A., Petralia, A., Cuzzocrea, S. and Calabrese, V., “Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: relevance to Alzheimer’s disease pathogenesis,” Neurotoxicology, 53. 350-358. March 2016.
[9]  Wasser, S. P., “Current findings, future trends, and unsolved problems in studies of medicinal mushrooms,” Applied Microbiology and Biotechnology, 89 (5). 1323-1332. March 2011.
[10]  Angelova, M., Dolashka-Angelova, P., Ivanova, E., Serkedjieva, J., Slokoska, L., Pashova, S., Toshkova, R., Vassilev, S., Simeonov, I., Hartmann, H. J., Stoeva, S., Weser, U. and Voelter, W., “A novel glycosylated Cu/Zn-containing superoxide dismutase: production and potential therapeutic effect,” Microbiology, 147 (Pt 6). 1641-1650. June 2001.
[11]  Erjavec, J., Kos, J., Ravnikar, M., Dreo, T. and Sabotic, J., “Proteins of higher fungi–from forest to application,” Trends in Biotechnology, 30 (5). 259-273. May 2012.
[12]  Chen, J., Jin, X., Zhang, L. and Yang, L., “A study on the antioxidant effect of Coriolus versicolor polysaccharide in rat brain tissues,” African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM/African Networks on Ethnomedicines, 10 (6). 481-484. October 2013.
[13]  Jiménez-Medina, E., Berruguilla, E., Romero, I., Algarra, I., Collado, A., Garrido, F. and Garcia-Lora, A., “The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis,” BMC Cancer, 8 (1). 78. January 2008.
[14]  Sakamoto, J., Morita, S., Oba, K., Matsui, T., Kobayashi, M., Nakazato, H. and Ohashi, Y., “Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials,” Cancer Immunology, Immunotherapy, 55 (4). 404-411. April 2006.
[15]  Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D. S., “Trametes versicolor extract modifies human fecal microbiota composition in vitro,” Plant Foods for Human Nutrition, 68 (2). 107-112. June 2013.
[16]  Hsu, W., Hsu, T., Lin, F., Cheng, Y. and Yang, J. P., “Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia.,” Carbohydrate Polymers, 92 (1). 297-306. January 2013.
[17]  Que, Y., Sun, S., Xu, L., Zhang, Y. and Zhu, H., “High-level coproduction, purification and characterisation of laccase and exopolysaccharides by Coriolus versicolor,” Food Chemistry, 159. 208-213. September 2014.
[18]  Lin, J.-P., Wei, L., Xia, L.-M. and Cen, P.-L., “Production of laccase by Coriolus versicolor and its application in decolorization of dyestuffs: (I). Production of laccase by batch and repeated-batch processes,” Journal of Environmental Sciences (China), 15 (1). 1-4. January 2003.
[19]  Arockiasamy, S., Krishnan, I. P. G., Anandakrishnan, N., Seenivasan, S., Sambath, A. and Venkatasubramani, J. P., “Enhanced production of laccase from Coriolus versicolor NCIM 996 by nutrient optimization using response surface methodology,” Applied Biochemistry and Biotechnology, 151 (2-3). 371-379. December 2008.
[20]  Cui, J. and Chisti, Y., “Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production,” Biotechnology Advances, 21 (2). 109-122. April 2003.
[21]  Ng, T. B., “A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae),” General Pharmacology, 30 (1). 1-4. January 1998.
[22]  Pallav, K., Dowd, S. E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D. A., Newburg, D. S. and Kelly, C. P., “Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial,” Gut Microbes, 5 (4). 458-467. July 2014.
[23]  Mao, X. W., Archambeau, J. O. and Gridley, D. S., “Immunotherapy with low-dose interleukin-2 and a polysaccharopeptide derived from Coriolus versicolor,” Cancer Biotherapy & Radiopharmaceuticals, 11 (6). 393-403. December 1996.
[24]  Dong, Y., Yang, M. M.-P., and Kwan, C.-Y., “In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs,” Life Sciences, 60 (8). PL135-PL140. January 1997.
[25]  Yang, M. M. P., Chen, Z. and Kwok, J. S. L., “The anti-tumor effect of a small polypeptide from Coriolus versicolor (SPCV),” The American Journal of Chinese Medicine, 20 (3-4). 221-232. January 1992.
[26]  Patel, S. and Goyal, A., “Recent developments in mushrooms as anti-cancer therapeutics: a review,” 3 Biotech, 2 (1). 1-15. March 2012.
[27]  Katoh, R. and Ooshiro, M., “Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models,” Cellular & Molecular Immunology, 4 (4). 295-299. August 2007.
[28]  Morimoto, T., Ogawa, M., Orita, K., Sugimachi, K., Toge, T., Dohi, K., Nomura, Y., Monden, Y. and Ogawa, N., “Postoperative adjuvant randomised trial comparing chemoendocrine therapy, chemotherapy and immunotherapy for patients with stage II breast cancer: 5-year results from the Nishinihon Cooperative Study Group of Adjuvant Chemoendocrine Therapy for Breast Cancer (ACETBC) of Japan,” European Journal of Cancer, 32A (2). 235-242. February 1996.
[29]  Hayakawa, K., Mitsuhashi, N., Saito, Y., Takahashi, M., Katano, S., Shiojima, K., Furuta, M. and Niibe, H., “Effect of krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer,” Anticancer Research, 13 (5C). 1815-1820. September-October 1993.
[30]  Ho, J. C. K., Konerding, M. a, Gaumann, A., Groth, M. and Liu, W. K., “Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice,” Life Sciences, 75 (11). 1343-56. July 2004.
[31]  Sekhon, B. K., Sze, D. M., Chan, W. K., Fan, K., Li, G. Q., Moore, D. E. and Roubin, R. H., “PSP activates monocytes in resting human peripheral blood mononuclear cells: Immunomodulatory implications for cancer treatment,” Food Chemistry, 138 (4). 2201-2209. June 2013.
[32]  Harhaji, L., Mijatović, S., Maksimović-Ivanić, D., Stojanović, I., Momcilović, M., Maksimović, V., Tufegdzić, S., Marjanović, Z., Mostarica-Stojković, M., Vucinić, Z. and Stosić-Grujicić, S., “Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study.,” Food and Chemical Toxicology, 46 (5). 1825-1833. May 2008.
[33]  Choi, J.-H., Kim, Y.-B., Lim, H.-Y., Park, J. S., Kim, H. C., Cho, Y. K., Han, S. W., Kim, M. W. and Joo, H. J., “5-fluorouracil, mitomycin-C, and polysaccharide-K adjuvant chemoimmunotherapy for locally advanced gastric cancer: the prognostic significance of frequent perineural invasion,” Hepatogastroenterology, 54 (73). 290–297. January-February 2007.
[34]  Lee, C. L., Yang, X. and Wan, J. M. F., “The culture duration affects the immunomodulatory and anticancer effect of polysaccharopeptide derived from Coriolus versicolor,” Enzyme and Microbial Technology, 38 (1-2). 14-21. January 2006.
[35]  Lau, C. B. S., Ho, C. Y., Kim, C. F., Leung, K. N., Fung, K. P., Tse, T. F., Chan, H. H. L. and Chow, M. S. S., “Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis,” Life Sciences, 75 (7). 797-808. July 2004.
[36]  Luo, K.-W., Yue, G. G.-L., Ko, C.-H., Lee, J. K.-M., Gao, S., Li, L.-F., Li, G., Fung, K.-P., Leung, P.-C. and Lau, C. B.-S., “In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma.,” Phytomedicine, 21 (8-9). 1078-1087. July-August 2014.
[37]  Pang, Z. J., Chen, Y., Zhou, M. and Wan, J., “Effect of polysaccharide Krestin on glutathione peroxidase gene expression in mouse peritoneal macrophages,” British Journal of Biomedical Science, 57 (2). 130-136. 2000.
[38]  Kozarski, M., Klaus, A., Nikšić, M., Vrvić, M. M., Todorović, N., Jakovljević, D. and Van Griensven, L. J. L. D., “Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor,” Journal of Food Composition and Analysis, 26 (1-2). 144-153. May-June 2012.
[39]  Collins, R. A. and Ng, T. B., “Polysaccharopeptide from Coriolus versicolor has potential for use against human immunodeficiency virus type 1 infection,” Life Sciences, 60 (25). PL383-PL387. May 1997.
[40]  Yeung, J. H. K. and Or, P. M. Y., “Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes,” Phytomedicine, 18 (13). 1170-1175. October 2011.
[41]  Yang, S., Zhuang, T., Si, Y., Qi, K. and Zhao, J., “Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways,” Molecular Immunology, 64 (1). 144-151. March 2015.
[42]  Fang, X., Jiang, Y., Ji, H., Zhao, L., Xiao, W., Wang, Z. and Ding, G., “The synergistic beneficial effects of ginkgo flavonoid and Coriolus versicolor polysaccharide for memory Improvements in a mouse model of dementia,” Evidence-Based Complementary and Alternative Medicine, 2015. 128394. 2015.
[43]  Fritz, H., Kennedy, D. A., Ishii, M., Fergusson, D., Fernandes, R., Cooley, K. and Seely, D., “Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review,” Integrative Cancer Therapies, 14 (3). 201-211. May 2015.
[44]  Fujita, H., Ogawa, K., Ikuzawa, M., Muto, S., Matsuki, M., Nakajima, S., Shimamura, M., Togawa, M., Yoshikumi, C. and Kawai, Y., “Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice,” International Journal of Immunopharmacology, 10 (4). 445-450. February 1988.
[45]  Sakagami, H. and Takeda, M., “Diverse biological activity of PSK (Krestin), a protein-bound polysaccharide from Coriolus versicolor (Fr.) Quel., in: Chang ST, Buswell JA, Chiu SW (eds).,” in Mushroom Biology and Mushroom Products., 1993, 237-245.
[46]  Chu, K. K. W., Ho, S. S. S. and Chow, A. H. L., “Coriolus versicolor: A medicinal mushroom with promising immunotherapeutic values,” Journal of Clinical Pharmacology, 42 (9). 976-984. September 2002.
[47]  Santos Arteiro, J. M., Martins, M. R., Salvador, C., Candeias, M. F., Karmali, A. and Caldeira, A. T., “Protein-polysaccharides of Trametes versicolor: production and biological activities,” Medicinal Chemistry Research, 21 (6). 937-943. June 2012.
[48]  Yang, J. P., Hsu, T., Lin, F., Hsu, W. and Chen, Y., “Potential antidiabetic activity of extracellular polysaccharides in submerged fermentation culture of Coriolus versicolor LH1.,” Carbohydrate Polymers, 90 (1). 174-80. September 2012.
[49]  Barros, A. B., Ferrão, J. and Fernandes, T., “A safety assessment of Coriolus versicolor biomass as a food supplement,” Food & Nutrition Research, 60. 29953. March 2016.
[50]  Li, G., Yu, K., Li, F., Xu, K., Li, J., He, S., Cao, S. and Tan, G., “Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers,” Journal of Ethnopharmacology, 153 (2). 521-530. April 2014.
[51]  Zhu, Y., Chen, Y., Li, Q., Zhao, T., Zhang, M., Feng, W., Takase, M., Wu, X., Zhou, Z., Yang, L. and Wu, X., “Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex,” Carbohydrate Polymers, 110. 231-237. September 2014.
[52]  Liu, J., Jia, L., Kan, J. and Jin, C.-H., “In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus),” Food and Chemical Toxicology, 51. 310–316. January 2013.
[53]  Ohno, N., Miura, N. N., Nakajima, M. and Yadomae, T., “Antitumor 1,3-beta-glucan from cultured fruit body of Sparassis crispa,” Biological & Pharmaceutical Bulletin, 23 (7). 866-872. July 2000.
[54]  Novak, M. and Vetvicka, V., “Glucans as biological response modifiers,” Endocrine, Metabolic & Immune Disorders Drug Targets, 9 (1). 67-75. March 2009.
[55]  Vannucci, L., Krizan, J., Sima, P., Stakheev, D., Caja, F., Rajsiglova, L., Horak, V. and Saieh, M., “Immunostimulatory properties and antitumor activities of glucans (Review),” International Journal of Oncology, 43 (2). 357-364. August 2013.
[56]  Wasser, S. P., “Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides,” Applied Microbiology and Biotechnology, 60 (3). 258-274. November 2002.
[57]  Zhang, M., Huang, J., Xie, X. and Holman, C. D. J., “Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women.,” International Journal of Cancer, 124 (6). 1404-1408. March 2009.
[58]  Kodama, N., Komuta, K., Sakai, N. and Nanba, H., “Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells,” Biological & Pharmaceutical Bulletin, 25 (12). 1647-1650. December 2002.
[59]  Ren, Z., Guo, Z., Meydani, S. N. and Wu, D., “White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice,” The Journal of Nutrition, 138 (3). 544-550. March 2008.
[60]  Moon, S.-M., Kim, J.-S., Kim, H.-J., Choi, M. S., Park, B. R., Kim, S.-G., Ahn, H., Chun, H. S., Shin, Y. K., Kim, J.-J., Kim, D. K., Lee, S.-Y., Seo, Y.-W., Kim, Y. H. and Kim, C. S., “Purification and characterization of a novel fibrinolytic α chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji,” Journal of Bioscience and Bioengineering, 117 (5). 544-550. May 2014.
[61]  Hara, C., Kiho, T., Tanaka, Y. and Ukai, S., “Anti-inflammatory activity and conformational behavior of a branched (1→3)-β-D-glucan from an alkaline extract of Dictyophora indusiata Fisch,” Carbohydrate Research, 110 (1). 77-87. November 1982.
[62]  Ker, Y.-B., Chen, K.-C., Peng, C.-C., Hsieh, C.-L. and Peng, R. Y., “Structural characteristics and antioxidative capability of the soluble polysaccharides present in Dictyophora indusiata (Vent. Ex Pers.) Fish Phallaceae,” Evidence-Based Complementary and Alternative Medicine, 2011. 396013. January 2011.
[63]  Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Suzuki, A. and Kushi, Y., “Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro,” Biochemical and Biophysical Research Communications, 373 (3). 435-439. August 2008.
[64]  Khanna, J. M., Malone, M. H., Euler, K. L. and Brady, L. R., “Atromentin. Anticoagulant from Hydnellum diabolus,” Journal of Pharmaceutical Sciences, 54 (7). 1016-1020. July 1965.
[65]  Zheng, C., Sohn, M. and Kim, W., “Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae,” The Journal of Antibiotics, 59 (12). 808-812. December 2006.
[66]  Jedinak, A., Dudhgaonkar, S., Wu, Q.-L., Simon, J. and Sliva, D., “Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling,” Nutrition Journal, 10 (1). 52. May 2011.
[67]  Cui, F.-J., Li, Y.-H., Zan, X.-Y., Yang, Y., Sun, W.-J., Qian, J.-Y., Zhou, Q. and Yu, S.-L., “Purification and partial characterization of a novel hemagglutinating glycoprotein from the cultured mycelia of Hericium erinaceus,” Process Biochemistry, 49 (8). 1362-1369. August 2014.
[68]  Neumann, T., Schlegel, B., Hoffmann, P., Heinze, S. and Gräfe, U., “Isolation and structure elucidation of new salfredin-type metabolites from Crucibulum laeve DSM 1653 and DSM 8519,” Journal of Basic Microbiology, 39 (5-6). 357-363. December 1999.
[69]  Chen, H., Ju, Y., Li, J. and Yu, M., “Antioxidant activities of polysaccharides from Lentinus edodes and their significance for disease prevention,” International Journal of Biological Macromolecules, 50 (1). 214-218. January 2012.
[70]  Hsu, S.-C., Ou, C.-C., Li, J.-W., Chuang, T.-C., Kuo, H.-P., Liu, J.-Y., Chen, C.-S., Lin, S.-C., Su, C.-H. and Kao, M.-C., “Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest,” Journal of Ethnopharmacology, 120 (3). 394-401. December 2008.
[71]  Hsu, S.-C., Ou, C.-C., Chuang, T.-C., Li, J.-W., Lee, Y.-J., Wang, V., Liu, J.-Y., Chen, C.-S., Lin, S.-C. and Kao, M.-C., “Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: in vitro and in vivo,” Cancer Letters, 281 (1). 108-116. August 2009.
[72]  Zhang, J., Wang, G., Li, H., Zhuang, C., Mizuno, T., Ito, H., Mayuzumi, H., Okamoto, H., and Li, J. “Antitumor active protein-containing glycans from the Chinese mushroom Songshan Lingzhi, Ganoderma tsugae mycelium,” Bioscience, Biotechnology, and Biochemistry, 58 (7). 1202-1205. 1994.
[73]  Palacios, I., Lozano, M., Moro, C., D’Arrigo, M., Rostagno, M. A., Martínez, J. A., García-Lafuente, A., Guillamón, E., and Villares, A., “Antioxidant properties of phenolic compounds occurring in edible mushrooms,” Food Chemistry, 128 (3). 674-678. October 2011.
[74]  Gibson, G. R., and Roberfroid, M. B., “Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics,” The Journal of Nutrition, 125 (6). 1401-1412. June 1995.
[75]  Gibson, G. R., Probert, H. M., Loo, J. Van, Rastall, R. A. and Roberfroid, M. B., “Dietary modulation of the human colonic microbiota: updating the concept of prebiotics.,” Nutrition Research Reviews, 17 (2). 259-275. December 2004.
[76]  EFSA, “Scientific Opinion on the substantiation of a health claim related to non-digestible carbohydrates and a reduction of post-prandial glycaemic responses pursuant to Article 13 (5) of Regulation (EC) No 1924/2006 1,” EFSA Journal, 12 (1). 3513. 2014.
[77]  EFSA, "Scientific Opinion on the substantiation of a health claim related to “native chicory inulin ” and maintenance of normal defecation by increasing stool frequency pursuant to Article 13 . 5 of Regulation (EC) No 1924/2006 1," EFSA Journal, 13 (1). 3951. 2015.
[78]  Lam, K.-L. and Cheung, P. C-K., “Non-digestible long chain beta-glucans as novel prebiotics,” Bioactive Carbohydrates and Dietary Fibre, 2 (1). 45-64. July 2013.
[79]  Chou, W.-T., Sheih, I.-C. and Fang, T. J., “The applications of polysaccharides from various mushroom wastes as prebiotics in different systems,” Journal of Food Science, 78 (7). M1041-M1048. July 2013.
[80]  Yamin, S., Shuhaimi, M, Arbakariya, A., Fatimah, A. B., Khalilah, A. K., Anas, O. and Yazid, A. M., “Effect of Ganoderma lucidum polysaccharides on the growth of Bifidobacterium spp. as assessed using Real-time PCR,” International Food Research Journal, 19 (3). 1199-1205. 2012.
[81]  Giannenas, I., Tsalie, E., Chronis, E., Mavridis, S., Tontis, D., and Kyriazakis, I., “Consumption of Agaricus bisporus mushroom affects the performance, intestinal microbiota composition and morphology, and antioxidant status of turkey poults,” Animal Feed Science and Technology, 165 (3-4). 218-229. May 2011.
[82]  Wang, H. X. and Ng, T. B., “A laccase from the medicinal mushroom Ganoderma lucidum,” Applied Microbiology and Biotechnology, 72 (3). 508-513. September 2006.
[83]  Wang, H. X. and Ng, T. B., “Purification of a laccase from fruiting bodies of the mushroom Pleurotus eryngii,” Applied Microbiology and Biotechnology, 69 (5). 521-525. January 2006.
[84]  Ngai, P. H. K. and Ng, T. B., “A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells,” Biochemical and Biophysical Research Communications, 314 (4). 988-993. February 2004.
[85]  Sabotič, J., Trček, T., Popovič, T. and Brzin, J., “Basidiomycetes harbour a hidden treasure of proteolytic diversity,” Journal of Biotechnology, 128 (2). 297-307. February 2007.
[86]  Zaidman, B.-Z., Yassin, M., Mahajna, J. and Wasser, S. P., “Medicinal mushroom modulators of molecular targets as cancer therapeutics,” Applied Microbiology and Biotechnology, 67 (4). 453-468. June 2005.