Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2016, 4(6), 355-360
DOI: 10.12691/jfnr-4-6-3
Open AccessArticle

Anti-obesity Effect and Antioxidant Activity in High-fat Diet Mice Fed Fermented Buckwheat Products (Miso)

Shan Wu1, 2, Shuo Feng1, 2, ZhaoHong Ci1, Chengyu Jiang1, Yang Cui1, Yuki Sasaki1, Yukina Ota1 and Michiyuki Kojima1,

1Department of Food Production Science, Obihiro University of Agriculture and Veterinary Medicine, 11, Nishi-2-sen, Inada-machi, Obihiro, Hokkaido 080-8555, Japan

2United Graduate School of Agricultural Sciences, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550, Japan

Pub. Date: July 05, 2016

Cite this paper:
Shan Wu, Shuo Feng, ZhaoHong Ci, Chengyu Jiang, Yang Cui, Yuki Sasaki, Yukina Ota and Michiyuki Kojima. Anti-obesity Effect and Antioxidant Activity in High-fat Diet Mice Fed Fermented Buckwheat Products (Miso). Journal of Food and Nutrition Research. 2016; 4(6):355-360. doi: 10.12691/jfnr-4-6-3


Here we examined the effects of consuming fermented buckwheat products in mice fed a high-fat diet. Buckwheat was fermented with soybeans (1:1) and rice koji for 6 months (miso). The total phenolic content and 1,1-diphenyl-2-picrylhydrazyl content of the buckwheat fermentation products (miso) increased with the time of fermentation. In the in vivo experiments, mice were fed for 5 weeks with a high-fat diet with or without supplementation using 10% buckwheat miso. Dietary supplementation with buckwheat miso significantly decreased the serum aspartate transaminase level and lipid peroxidation in the liver compared with the control group. Furthermore, the mice that received buckwheat miso showed significant decreases in their body weight and retroperitoneal and mesenteric fat weights and increased fecal lipid contents compared with the control group. These results indicate that dietary supplementation with buckwheat, which is characterized by a high antioxidant activity, has health benefits such as protection of the liver and suppression of increased body weight.

buckwheat miso high-fat diet antioxidant anti-obesity total phenolic content

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