Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2016, 4(3), 137-147
DOI: 10.12691/jfnr-4-3-2
Open AccessArticle

Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice

Zwe-Ling Kong1, , Ning-Jo Kao1, Jia-Yuan Hu1 and Chien-Sheng Wu1

1Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan

Pub. Date: March 26, 2016

Cite this paper:
Zwe-Ling Kong, Ning-Jo Kao, Jia-Yuan Hu and Chien-Sheng Wu. Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice. Journal of Food and Nutrition Research. 2016; 4(3):137-147. doi: 10.12691/jfnr-4-3-2

Abstract

Fucoxanthin is a natural carotenoid that is isolated from seaweed. We evaluated the effects of fucoxanthin-rich brown algae extract (FX-BAE) on the development of dextran sulfate sodium (DSS)-induced colitis, and colitis-associated colon cancer (CACC) in BALB/c mice. Colitis mice were given drinking water containing 3% DSS for 14 days, and fed with or without FX-BAE (1, 2.5, or 5 g/kg bodyweight/day) from day 8 to day 14. Another way, CACC mice were treated with azoxymethane (AOM) and 2% DSS, and fed with or without FX-BAE at 0.5, 1, or 2.5 g/kg every 2 days. Results revealed the disease activity index (DAI), nitric oxide (NO), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were all significantly less in FX-BAE treated mice. Additionally, FX-BAE not only decreased the incidence of colonic neoplasm, but also increased superoxide dismutase (SOD) production, lymphocyte proliferation and survival rate in CACC mice.

Keywords:
fucoxanthin colitis colon cancer inflammation dextran sulfate sodium

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References:

[1]  Bharti, A.C., Donato, N., Singh, S., Aggarwal, B.B., 2003. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101, 1053-1062.
 
[2]  Bird, R.P., Good, C.K., 2000. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicology Letters 112–113, 395-402.
 
[3]  Britton, G., 1995. Structure and properties of carotenoids in relation to function. The FASEB Journal 9, 1551-1558.
 
[4]  Caprilli, R., Viscido, A., Latella, G., 2007. Current management of severe ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 4, 92-101.
 
[5]  Carter, A.B., Misyak, S.A., Hontecillas, R., Bassaganya-Riera, J., 2009. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR& NF-κB. PPAR Research 2009.
 
[6]  Cooper, H.S., Murthy, S.N., Shah, R.S., Sedergran, D.J., 1993. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 69, 238-249.
 
[7]  Cosnes, J., Gower–Rousseau, C., Seksik, P., Cortot, A., 2011. Epidemiology and Natural History of Inflammatory Bowel Diseases. Gastroenterology 140, 1785-1794.e1784.
 
[8]  Coussens, L.M., Werb, Z., 2002. Inflammation and cancer. Nature 420, 860-867.
 
[9]  Cui, X., Jin, Y., Hofseth, A.B., Pena, E., Habiger, J., Chumanevich, A., Poudyal, D., Nagarkatti, M., Nagarkatti, P.S., Singh, U.P., Hofseth, L.J., 2010. Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis. Cancer Prevention Research 3, 549-559.
 
[10]  Cunnick, J.E., Kojic, L.D., Hughes, R.A., 1994. Stress-Induced Changes in Immune Function Are Associated with Increased Production of an Interleukin-1-like Factor in Young Domestic Fowl. Brain, Behavior, and Immunity 8, 123-136.
 
[11]  D’Orazio, N., Gemello, E., Gammone, M. A., Girolamo, M, Ficoneri, C, and Riccioni, G., 2012. Fucoxantin: A Treasure from the Sea. Mar. Drugs 10, 604-616.
 
[12]  Deguchi, Y., Andoh, A., Inatomi, O., Yagi, Y., Bamba, S., Araki, Y., Hata, K., Tsujikawa, T., Fujiyama, Y., 2007. Curcumin Prevents the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis. Dig Dis Sci 52, 2993-2998.
 
[13]  Ding, S., Walton, K.L.W., Blue, R.E., MacNaughton, K., Magness, S.T., Lund, P.K., 2012. Mucosal Healing and Fibrosis after Acute or Chronic Inflammation in Wild Type FVB-N Mice and C57BL6 Procollagen α1(I)-Promoter-GFP Reporter Mice. PLoS One. 2012; 7(8): e42568. 7, e42568-e42574.
 
[14]  Du, C., and Wang, Y., 2011. The immunoregulatory mechanisms of carcinoma for its survival and developmen. J Exp Clin Cancer Res 30, 1-10.
 
[15]  Engel, M., Neurath, M., 2010. New pathophysiological insights and modern treatment of IBD. J Gastroenterol 45, 571-583.
 
[16]  Evans, N.P., Misyak, S.A., Schmelz, E.M., Guri, A.J., Hontecillas, R., Bassaganya-Riera, J., 2010. Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPARγ. The Journal of Nutrition 140, 515-521.
 
[17]  Gommeaux, J., Cano, C., Garcia, S., Gironella, M., Pietri, S., Culcasi, M., Pébusque, M.-J., Malissen, B., Dusetti, N., Iovanna, J., Carrier, A., 2007. Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1. Molecular and Cellular Biology 27, 2215-2228.
 
[18]  Haugan, J.A., Aakermann, T., Liaaen-Jensen, S., 1992. Isolation of fucoxanthin and peridinin, in: P. Lester (Ed.), Methods in Enzymology. Academic Press, pp. 231-245.
 
[19]  Heo, S.J., Yoon, W.J., Kim, K.N., Oh, C., Choi, Y.U., Yoon, K.T., Kang, D.H., Qian, Z.J., Choi, I.-W., Jung, W.-K., 2012. Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage. Food and Chemical Toxicology 50, 3336-3342.
 
[20]  Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., Miyashita, K., 2004. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1675, 113-119.
 
[21]  Hu, T., Liu, D., Chen, Y., Wu, J., Wang, S., 2010. Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. International Journal of Biological Macromolecules 46, 193-198.
 
[22]  Jung H.C., Kim, J.M., Song, I.S., Kim, C.Y., 1997. Helicobacter pylori induces an array of pro-inflammatory cytokines in human gastric epithelial cells: quantification of mRNA for interleukin-8, -1 alpha/beta, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1 and tumour necrosis factor-alpha. J Gastroenterol Hepatol. 12, 473-480.
 
[23]  Kane, S.V., Schoenfeld, P., Sandborn, W.J., Tremaine, W., Hofer, T., Feagan, B.G., 2002. Systematic review: the effectiveness of budesonide therapy for Crohn's disease. Alimentary Pharmacology & Therapeutics 16, 1509-1517.
 
[24]  Kim, J.M., Araki, S., Kim, D.J., Park, C.B., Takasuka, N., Baba-Toriyama, H., Ota, T., Nir, Z., Khachik, F., Shimidzu, N., Tanaka, Y., Osawa, T., Uraji, T., Murakoshi, M., Nishino, H., Tsuda, H., 1998. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis 19, 81-85.
 
[25]  Kim, K.N., Heo, S.J., Yoon, W.J., Kang, S.M., Ahn, G., Yi, T.H., Jeon, Y.J., 2010. Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. European Journal of Pharmacology 649, 369-375.
 
[26]  Kim, S.K., Ravichandran, Y., Khan, S., Kim, Y., 2008. Prospective of the cosmeceuticals derived from marine organisms. Biotechnology and Bioprocess Engineering 13, 511-523.
 
[27]  Lakhan, S., Kirchgessner, A., 2010. Neuroinflammation in inflammatory bowel disease. Journal of Neuroinflammation 7, 37.
 
[28]  Lawrence, T., Willoughby, D.A., Gilroy, D.W., 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2, 787-795.
 
[29]  Maeda, H., Tsukui, T., Sashima, T., Hosokawa, M., Miyashita, K., 2008. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr. 17 196-199.
 
[30]  Meira, L.B., Bugni, J.M., Green, S.L., Lee, C.-W., Pang, B., Borenshtein, D., Rickman, B.H., Rogers, A.B., Moroski-Erkul, C.A., McFaline, J.L., Schauer, D.B., Dedon, P.C., Fox, J.G., Samson, L.D., 2008. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. The Journal of Clinical Investigation 118, 2516-2525.
 
[31]  Palacios, M.G., Cunnic, J.E., Winkler, D.W., Vleck, C.M., 2007. Immunosenescence in some but not all immune components in a free-living vertebrate, the tree swallow. Proc Biol Sci. 2749, 951-957.
 
[32]  Qian, J., Chen, F., Kovalenkov, Y., Pandey, D., Moseley, M.A., Foster, M.W., Black, S.M., Venema, R.C., Stepp, D.W., Fulton, D.J.R., 2012. Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. Free Radical Biology and Medicine 52, 1806-1819.
 
[33]  Riccioni, G., 2012. Marine Carotenoids and Oxidative Stress. Marine Drugs 10, 116-118.
 
[34]  Rocha, F.D., Soares, A.R., Houghton, P.J., Pereira, R.C., Kaplan, M.A.C., Teixeira, V.L., 2007. Potential cytotoxic activity of some Brazilian seaweeds on human melanoma cells. Phytotherapy Research 21, 170-175.
 
[35]  Roessner, A., Kuester, D., Malfertheiner, P., Schneider-Stock, R., 2008. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathology - Research and Practice 204, 511-524.
 
[36]  Sharma, R.A., Gescher, A.J., Steward, W.P., 2005. Curcumin: The story so far. European journal of cancer (Oxford, England : 1990) 41, 1955-1968.
 
[37]  Shen, L.R., Xiao, F., Yuan, P., Chen, Y., Gao, Q.K., Parnell, L., Meydani, M., Ordovas, J., Li, D., Lai, C.Q., 2012. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. AGE, 1-10.
 
[38]  Shiratori, K., Ohgami, K., Ilieva, I., Jin, X.H., Koyama, Y., Miyashita, K., Yoshida, K., Kase, S., Ohno, S., 2005. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Experimental Eye Research 81, 422-428.
 
[39]  Sugawara, T., Kushiro, M., Zhang, H., Nara, E., Ono, H., Nagao, A., 2001. Lysophosphatidylcholine Enhances Carotenoid Uptake from Mixed Micelles by Caco-2 Human Intestinal Cells. The Journal of Nutrition 131, 2921-2927.
 
[40]  Takashima, M., Shichiri, M., Hagihara, Y., Yoshida, Y., Niki, E., 2012. Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems. Free Radical Research 46, 1406-1412.
 
[41]  Tanaka, T., Shnimizu, M., Moriwaki, H., 2012. Cancer Chemoprevention by Carotenoids. Molecules 17, 3202-3242.
 
[42]  Thomsen, O.Ø., Cortot, A., Jewell, D., Wright, J.P., Winter, T., Veloso, F.T., Vatn, M., Persson, T., Pettersson, E., 1998. A Comparison of Budesonide and Mesalamine for Active Crohn's Disease. New England Journal of Medicine 339, 370-374.
 
[43]  Vershinin, A., 1999. Biological functions of carotenoids--diversity and evolution. Biofactors. 10, 99-104.
 
[44]  Yamamoto, K., Ishikawa, C., Katano, H., Yasumoto, T., Mori, N., 2011. Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas. Cancer letters 300, 225-234.
 
[45]  Zitvogel, L., Kepp, O., Galluzzi, L., Kroemer, G., 2012. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol 13, 343-351.